Fluid Flow Behaviour in Microneedle Arrays

2005 ◽  
Author(s):  
A. N. San ◽  
R. Ben Mrad ◽  
P. Sullivan
Keyword(s):  
Drug Delivery ◽  
Fluid Flow ◽  
Cross Sections ◽  
Transdermal Drug Delivery ◽  
Interstitial Fluid ◽  
Flow Behaviour ◽  
Electrokinetic Effect ◽  
Microneedle Arrays ◽  
Minor Losses ◽  
Array Geometry

This paper examines the geometries of basic straight microneedle arrays, slanted channel arrays with varying angles, and arrays with diverging and converging interior cross sections for the purpose of interstitial fluid extraction and transdermal drug delivery. Flow behaviour is analyzed under biometric pressure driven conditions including frictional losses, minor losses due to the array geometry, and losses due to electrokinetic effect in microchannels. This paper also presents design and fabrication details of preliminary work that will lead to a design for microneedle arrays.

Microneedle arrays as medical devices for enhanced transdermal drug delivery

2011 ◽  
Vol 8 (4) ◽  
pp. 459-482 ◽  
Author(s):  
Martin J Garland ◽  
Katarzyna Migalska ◽  
Tuan Mazlelaa Tuan Mahmood ◽  
Thakur Raghu Raj Singh ◽  
A David Woolfson ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Medical Devices ◽  
Transdermal Drug Delivery ◽  
Microneedle Arrays

Preparation of hollow out-of-plane hafnium oxide microneedle arrays for transdermal drug delivery

2017 ◽  
Vol 23 (12) ◽  
pp. 5887-5892 ◽  
Author(s):  
Yong-hua Zhang ◽  
Stephen A. Campbell ◽  
Sreejith Karthikeyan
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Hafnium Oxide ◽  
Out Of Plane ◽  
Microneedle Arrays

Fabrication and Evaluation of Thermally Crosslinked Gantrez S-97 Microneedle Arrays

2020 ◽  
Vol 859 ◽  
pp. 39-44
Author(s):  
Yin Yin Myat ◽  
Nway Nway Aung ◽  
Tanasait Ngawhirunpat ◽  
Theerasak Rojanarata ◽  
Praneet Opanasopit ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Ir Spectra ◽  
Transdermal Drug Delivery ◽  
Thermal Process ◽  
Swelling Properties ◽  
Digital Microscope ◽  
Ft Ir ◽  
Microneedle Arrays

The aim of this study was to develop a thermal crosslinkable microneedle (MN) array. Gantrez S-97 was employed as the MN-forming polymer. The MNs were successfully fabricated by micromolding method. The MNs were thermally crosslinked at different times (0.5, 1, 2, 3 h) and temperatures (110, 130, 150°C). The morphology of the MN was observed using a digital microscope. The successful crosslink was confirmed by Fourier transform infrared spectroscopy. The percentages of swelling and MN remaining after being soaked in water were also investigated. Fully formed, sharped MN with desirable morphology was obtained at the Gantrez S-97 concentration of 30 %w/v. The FT-IR spectra confirmed the successful crosslink of the MN. The crosslinked Gantrez MN arrays could absorb massive amount of water, and exhibited excellent swelling capability. Increasing the crosslinking time and temperature resulted in the decrease in the swelling capability but increase in the water insolubilization. The MNs crosslinked at 150°C for 3 h demonstrated almost hundred percent of water insolubilization which desirable for developing hydrogel-forming MN. Therefore, 30% w/v Gantrez S-97 MN could be crosslinked by thermal process, and could provide desirable swelling properties and percentage of water insolubility, and therefore, may be an alternative for fabrication of hydrogel-forming MN for transdermal drug delivery.

Sign in / Sign up

Export Citation Format

Share Document