Enhanced Air-Gap Control for High-Speed Plasmonic Lithography Using Solid Immersion Lens With Sharp-Ridge Nanoaperture

Recently, plasmonic nanolithography is studied by many researchers (1, 2 and 3). This presented a low-cost and high-throughput approach to maskless nanolithography technique that uses a metallic sharp-ridge nanoaperture with a high strong nanometer-sized optical spot induced by surface plasmon resonance. However, these nanometer-scale spots generated by metallic nanoapertures are formed in only the near-field region, which makes it very difficult to pattern above the photoresist surface at high-speeds.

Download Full-text

Rapid Antibody Selection Using Surface Plasmon Resonance for High-Speed and Sensitive Hazelnut Lateral Flow Prototypes

Biosensors ◽

10.3390/bios8040130 ◽

2018 ◽

Vol 8 (4) ◽

pp. 130 ◽

Cited By ~ 6

Author(s):

Georgina Ross ◽

Maria Bremer ◽

Jan Wichers ◽

Aart van Amerongen ◽

Michel Nielen

Keyword(s):

Surface Plasmon Resonance ◽

Surface Plasmon ◽

Plasmon Resonance ◽

High Speed ◽

Selection Process ◽

Low Cost ◽

Real Life ◽

Cross Reactivity ◽

Lateral Flow ◽

Label Free

Lateral Flow Immunoassays (LFIAs) allow for rapid, low-cost, screening of many biomolecules such as food allergens. Despite being classified as rapid tests, many LFIAs take 10–20 min to complete. For a really high-speed LFIA, it is necessary to assess antibody association kinetics. By using a label-free optical technique such as Surface Plasmon Resonance (SPR), it is possible to screen crude monoclonal antibody (mAb) preparations for their association rates against a target. Herein, we describe an SPR-based method for screening and selecting crude anti-hazelnut antibodies based on their relative association rates, cross reactivity and sandwich pairing capabilities, for subsequent application in a rapid ligand binding assay. Thanks to the SPR selection process, only the fast mAb (F-50-6B12) and the slow (S-50-5H9) mAb needed purification for labelling with carbon nanoparticles to exploit high-speed LFIA prototypes. The kinetics observed in SPR were reflected in LFIA, with the test line appearing within 30 s, almost two times faster when F-50-6B12 was used, compared with S-50-5H9. Additionally, the LFIAs have demonstrated their future applicability to real life samples by detecting hazelnut in the sub-ppm range in a cookie matrix. Finally, these LFIAs not only provide a qualitative result when read visually, but also generate semi-quantitative data when exploiting freely downloadable smartphone apps.

Download Full-text

Interface between Nanophotonics and Biotechnology: How the Near-Field Can Boost Proteomics Based on LSPR Nano Sensor

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.139-141.1554 ◽

2010 ◽

Vol 139-141 ◽

pp. 1554-1557 ◽

Cited By ~ 1

Author(s):

Xi Xi Huang ◽

Zhong Cao ◽

Yong Le Liu ◽

Yi Min Dai ◽

Ju Lan Zeng ◽

...

Keyword(s):

Surface Plasmon Resonance ◽

Surface Plasmon ◽

Plasmon Resonance ◽

Low Cost ◽

Near Field ◽

Visible Region ◽

High Sensitivity ◽

Nano Particles ◽

Localized Surface Plasmon ◽

Bioanalytical Application

An novel optical nano biosensor based on gold capped nano-particles for detecting binding events between ligands and receptor molecules as well as interactions among proteins without use of labels has been presented in this paper. The optical properties of nano-sized gold particles exhibiting pronounced adsorption in the visible region which called as localized surface plasmon resonance (LSPR) have been exploited, whose peak wavelengths depended exquisitely on the refractive index of the surrounding. In comparison with surface plasmon resonance (SPR) technology, the optical nano biosensor possessed high sensitivity, surprisingly low “bulk effect”, ease of preparation, and low-cost polymer based fabrication, which opened a promising bioanalytical application in practice.

Download Full-text

Microstructured Surface Plasmon Resonance Sensor Based on Inkjet 3D Printing Using Photocurable Resins with Tailored Refractive Index

Polymers ◽

10.3390/polym13152518 ◽

2021 ◽

Vol 13 (15) ◽

pp. 2518

Author(s):

Nunzio Cennamo ◽

Lorena Saitta ◽

Claudio Tosto ◽

Francesco Arcadio ◽

Luigi Zeni ◽

...

Keyword(s):

Surface Plasmon Resonance ◽

3D Printing ◽

Surface Plasmon ◽

Plasmon Resonance ◽

Optical Sensor ◽

Low Cost ◽

3D Print ◽

Spr Sensor ◽

Resonance Sensor ◽

3D Printed

In this work, a novel approach to realize a plasmonic sensor is presented. The proposed optical sensor device is designed, manufactured, and experimentally tested. Two photo-curable resins are used to 3D print a surface plasmon resonance (SPR) sensor. Both numerical and experimental analyses are presented in the paper. The numerical and experimental results confirm that the 3D printed SPR sensor presents performances, in term of figure of merit (FOM), very similar to other SPR sensors made using plastic optical fibers (POFs). For the 3D printed sensor, the measured FOM is 13.6 versus 13.4 for the SPR-POF configuration. The cost analysis shows that the 3D printed SPR sensor can be manufactured at low cost (∼15 €) that is competitive with traditional sensors. The approach presented here allows to realize an innovative SPR sensor showing low-cost, 3D-printing manufacturing free design and the feasibility to be integrated with other optical devices on the same plastic planar support, thus opening undisclosed future for the optical sensor systems.

Download Full-text

An Enhanced Plastic Optical Fiber-Based Surface Plasmon Resonance Sensor with a Double-Sided Polished Structure

Sensors ◽

10.3390/s21041516 ◽

2021 ◽

Vol 21 (4) ◽

pp. 1516

Author(s):

Lian Liu ◽

Shijie Deng ◽

Jie Zheng ◽

Libo Yuan ◽

Hongchang Deng ◽

...

Keyword(s):

Surface Plasmon Resonance ◽

Optical Fiber ◽

Surface Plasmon ◽

Plasmon Resonance ◽

Low Cost ◽

Fiber Axis ◽

Plastic Optical Fiber ◽

Au Film ◽

Spr Sensor ◽

Resonance Sensor

An enhanced plastic optical fiber (POF)-based surface plasmon resonance (SPR) sensor is proposed by employing a double-sided polished structure. The sensor is fabricated by polishing two sides of the POF symmetrically along with the fiber axis, and a layer of Au film is deposited on each side of the polished region. The SPR can be excited on both polished surfaces with Au film coating, and the number of light reflections will be increased by using this structure. The simulation and experimental results show that the proposed sensor has an enhanced SPR effect. The visibility and full width at half maximum (FWHM) of spectrum can be improved for the high measured refractive index (RI). A sensitivity of 4284.8 nm/RIU is obtained for the double-sided POF-based SPR sensor when the measured liquid RI is 1.42. The proposed SPR sensor is easy fabrication and low cost, which can provide a larger measurement range and action area to the measured samples, and it has potential application prospects in the oil industry and biochemical sensing fields.

Download Full-text