Planar Waveguide: Utility in Amino Acid Detection

2003 ◽  
Author(s):  
David R. Wulfman ◽  
Tracey Baas ◽  
Ronald McGlennen
Keyword(s):  
Medical Care ◽  
Planar Waveguide ◽  
Low Cost ◽  
Test Results ◽  
Gene Detection ◽  
Excitation Light ◽  
Future Design ◽  
Standard Glass ◽  
Cost System ◽  
Glass Microscope Slide

A device for the detection of fluorescently labeled nucleic acid sequences immobilized or hybridized to the surface of a planar waveguide has been developed. The device described requires no image gathering or analysis utilities, nor any specially patterned waveguide surface for detection. The system consists of an excitation light source and a photo detector, filters for select fluorescent emissions and a standard glass microscope slide that functions as a planar waveguide (PWG) and assay substrate. The device can discriminate fluorescent DNA products hybridized to a glass based array as effectively as laser based reader instruments, and is a low cost system with a high potential for full automation. The system’s functional parameters are presented along with design schematics of current prototypes. Performance data is also presented showing test results comparable to pre-established fluorescence detection means. Future design goals are also discussed. It is concluded that as a component in telemedicine or other remote medical care strategies, the detection means presented can play a significant role in bringing molecular diagnosis and gene detection to arenas of medical care where it is currently unavailable.

Planar Waveguide Genetic Assay Readout Device

2003 ◽  
Author(s):  
David R. Wulfman ◽  
Tracey L. Baas ◽  
Ronald C. McGlennen
Keyword(s):  
Planar Waveguide ◽  
Effective Means ◽  
Glass Slide ◽  
Microscope Slide ◽  
Excitation Light ◽  
Fluorescent Intensity ◽  
Sensing System ◽  
Glass Microscope Slide ◽  
Glass Microscope ◽  
Genetic Assay

A planar waveguide (PWG) device has been developed for the detection of fluorescently labeled nucleic acid sequences immobilized or hybridized to the surface of a planar waveguide. Unlike current technologies requiring image gathering and reading capabilities or specially textured waveguide surfaces, this instrument uses simple glass slide based arrays, providing a numerical output in proportion to the fluorescent intensity recorded. The system consists of an optical waveguide (a glass microscope slide), an excitation light source, a photo detector, filters for select fluorescent emissions and the positioning array cassette. A data analysis algorithm is presented for interpretation of two dimensionally organized arrays. Based on our experimental evaluations we conclude that this sensing system shows promise as a simple and effective means to read fluorescent microarrays.

scholarly journals Development of a Low-Cost System for the Accurate Measurement of Structural Vibrations

Sensors ◽  
2021 ◽  
Vol 21 (18) ◽  
pp. 6191
Author(s):  
Seyedmilad Komarizadehasl ◽  
Behnam Mobaraki ◽  
Haiying Ma ◽  
Jose-Antonio Lozano-Galant ◽  
Jose Turmo
Keyword(s):  
Data Acquisition ◽  
Low Cost ◽  
Fast Fourier Transformation ◽  
Test Results ◽  
Structural Vibrations ◽  
Case Scenario ◽  
Worst Case ◽  
Low Frequencies ◽  
Cost System ◽  
Arduino Microcontroller

Nowadays, engineers are widely using accelerometers to record the vibration of structures for structural verification purposes. The main obstacle for using these data acquisition systems is their high cost, which limits its use to unique structures with a relatively high structural health monitoring budget. In this paper, a Cost Hyper-Efficient Arduino Product (CHEAP) has been developed to accurately measure structural accelerations. CHEAP is a system that is composed of five low-cost accelerometers that are connected to an Arduino microcontroller as their data acquisition system. Test results show that CHEAP not only has a significantly lower price (14 times cheaper in the worst-case scenario) compared with other systems used for comparison but also shows better accuracy on low frequencies for low acceleration amplitudes. Moreover, the final output results of Fast Fourier Transformation (FFT) assessments showed a better observable resolution for CHEAP than the studied control systems.

Low-Cost System Handles Patient Phone Calls

2007 ◽  
Vol 40 (11) ◽  
pp. 53
Author(s):  
BRUCE K. DIXON
Keyword(s):  
Low Cost ◽  
Cost System ◽  
Phone Calls

Intelligent, low-cost system for fume control during laser material processing

2005 ◽  
Author(s):  
Ramin Sattari ◽  
Stephan Barcikowski ◽  
Thomas Püster ◽  
Andreas Ostendorf ◽  
Heinz Haferkamp
Keyword(s):  
Material Processing ◽  
Low Cost ◽  
Laser Material Processing ◽  
Laser Material ◽  
Cost System

scholarly journals A Low-cost System for High-frequency Solar Imagery and Power Data Acquisition

2021 ◽  
Vol 1826 (1) ◽  
pp. 012082
Author(s):  
G F Bassous ◽  
R F Calili ◽  
C R H Barbosa
Keyword(s):  
Data Acquisition ◽  
High Frequency ◽  
Low Cost ◽  
Cost System

Low-cost system in the analysis of the recovery of mobility through inertial navigation techniques and virtual reality

2021 ◽  
pp. 271-292
Author(s):  
Wilver Auccahuasi ◽  
Mónica Diaz ◽  
Fernando Sernaque ◽  
Edward Flores ◽  
Justiniano Aybar ◽  
...  
Keyword(s):  
Virtual Reality ◽  
Low Cost ◽  
Inertial Navigation ◽  
Cost System

Low-cost system for radiometric calibration of UAV-based multispectral imagery

2020 ◽  
pp. 1-15
Author(s):  
Jorge Tadeu Fim Rosas ◽  
Francisco de Assis de Carvalho Pinto ◽  
Daniel Marçal de Queiroz ◽  
Flora Maria de Melo Villar ◽  
Rodrigo Nogueira Martins ◽  
...  
Keyword(s):  
Low Cost ◽  
Multispectral Imagery ◽  
Radiometric Calibration ◽  
Cost System

A pragmatic eLCR for an ultrasensitive detection of methicillin-resistant Staphylococcus aureus in joint synovial fluid: superior to qPCR

The Analyst ◽  
2021 ◽  
Author(s):  
Jinyuan Chen ◽  
Hongxiang Wei ◽  
Xinyu Fang ◽  
Yuanqing Cai ◽  
Zhenzhen Zhang ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Synovial Fluid ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Detection Method ◽  
Low Cost ◽  
Ultrasensitive Detection ◽  
Gene Detection ◽  
Methicillin Resistant ◽  
Cost Identification

A pragmatic electrochemical mecA gene detection method for a rapid, accurate and low-cost identification of MRSA in the joint synovial fluid of PJI patients.

Validation of low-cost system for gait assessment in children with ataxia

2020 ◽  
Vol 196 ◽  
pp. 105705 ◽  
Author(s):  
S. Summa ◽  
G. Tartarisco ◽  
M. Favetta ◽  
A. Buzachis ◽  
A. Romano ◽  
...  
Keyword(s):  
Low Cost ◽  
Gait Assessment ◽  
Cost System
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