A Fluid-Structure Interaction Model for 3D Heart Valve Dynamics

2008 ◽  
Author(s):  
Sarah C. Vigmostad ◽  
H. S. Udaykumar ◽  
Jia Lu ◽  
Michael S. Sacks ◽  
K. B. Chandran
Keyword(s):  
Heart Valve ◽  
Heart Valves ◽  
Interaction Model ◽  
Quantitative Information ◽  
Bioprosthetic Heart Valve ◽  
Bioprosthetic Heart Valves ◽  
Operational Life ◽  
Hemodynamic Characteristics ◽  
Valve Dynamics ◽  
Opening And Closing

Bioprosthetic heart valves are valve replacements constructed from animal tissue. Although they are geometrically similar to native aortic valves and offer comparable hemodynamic characteristics in their function, they have limited operational life, often requiring replacement 10–15 years after implantation. Though much is still unknown about bioprosthetic heart valve failure, it is generally accepted that this failure is to some extent due to structural decomposition. Although the mechanism for degradation is not clearly understood, it has been observed that these regions of failure are typically in locations where the leaflet undergoes large flexion and high compressive and tensile stresses [1]. An understanding of bioprosthetic heart valve failure necessitates detailed quantitative information on the complex motion of and the stresses on the leaflets particularly during the opening and closing phases and their relationship to structural failure.

Simulations of Bioprosthetic Heart Valve Dynamics Using a Sharp Interface Method

2007 ◽  
Author(s):  
Sarah C. Vigmostad ◽  
Brian D. Jeffrey ◽  
Sreedevi Krishnan ◽  
H. S. Udaykumar ◽  
K. B. Chandran
Keyword(s):  
Mechanical Properties ◽  
Heart Valve ◽  
Heart Valves ◽  
Animal Tissue ◽  
Shear Stresses ◽  
Bioprosthetic Heart Valve ◽  
Bioprosthetic Heart Valves ◽  
Sharp Interface Method ◽  
Valve Dynamics ◽  
Heart Valve Dynamics

Bioprosthetic heart valves are valve replacements constructed from animal tissue. They are deformable and offer similar mechanical properties to their native counterpart. While tearing of these valves is frequently observed, it is still not fully understood, but may be the result of high induced bending and shear stresses in the valve leaflets[1].

Biomechanical Simulations of Bioprosthetic Heart Valve Deformations

2006 ◽  
Author(s):  
Wei Sun ◽  
Hengchu Cao ◽  
Jim Davidson ◽  
Michael Sacks
Keyword(s):  
Heart Valve ◽  
Heart Valves ◽  
Stress Concentrations ◽  
Bioprosthetic Heart Valves ◽  
Structural Fatigue ◽  
Structural Deterioration ◽  
Bending Stresses ◽  
Improved Performance ◽  
Valve Prostheses ◽  
Opening And Closing

Previous research has suggested that the structural deterioration in porcine bioprosthetic heart valves (BHV) may be correlated with the regions of high tensile and bending stresses acting on the leaflets during opening and closing[1, 2]. Stress concentrations within the cusp can either directly accelerate tissue structural fatigue damage, or initiate calcification by causing structural disintegration, enabling multiple pathways of calcification that can lead to valve failure[3,4]. In the case of bovine pericardial heart valve prostheses, structural failure of the leaflets is rare but calcification has been observed. Although details of the process are unclear, it is generally assumed that the design of the pericardial valve, which gives a stress-reduced state of the leaflets, is likely to provide improved performance in long-term applications.

scholarly journals MECHANISMS UNDERLYING BIOPROSTHETIC HEART VALVE DYSFUNCTIONS

2018 ◽  
Vol 7 (2) ◽  
pp. 10-24 ◽  
Author(s):  
L. S. Barbarash ◽  
N. V. Rogulina ◽  
N. V. Rutkovskaya ◽  
E. A. Ovcharenko
Keyword(s):  
Heart Valve ◽  
Heart Valves ◽  
Negative Impact ◽  
Natural Aging ◽  
Bioprosthetic Heart Valve ◽  
Negative Effects ◽  
Related Factors ◽  
Bioprosthetic Heart Valves ◽  
Pathogenetic Mechanisms

The article presents new insights into the mechanisms underlying bioprosthetic heart valve dysfunctions based on the medical literature analysis. We highlighted the main pathogenetic mechanisms causing dysfunctions of bioprosthetic heart valves among the well-known and recently studied ones. In addition to the process of natural “aging” of the valve tissue that develops during continuous cyclic mechanical loads and is accompanied by the formation of calcification foci (passive and active calcification process), the negative impact of prosthesis- and recipientrelated factors has been evaluated. The prosthesis-related factors contributing to the development of dysfunctions include technological and technical factors, which may produce negative effects on bioprosthetic heart valves during the preimplantation preparation and implantation itself. Main dysmetabolic, immune, hemostasis and hyperproliferative (hyperplastic) mechanisms have been reviewed from the standpoint of the recipient-related factors that may shorten the lifespan of bioprostheses. Therefore, we propose a classification of bioprosthetic heart valve dysfunctions based on the underlying pathogenetic mechanisms and specific morphological patterns.

Nonlinear Analysis of Bioprosthetic Heart Valves under Dynamic Loading

2012 ◽  
Vol 152-154 ◽  
pp. 732-736
Author(s):  
Quan Yuan ◽  
Xin Ye ◽  
Hai Bo Ma ◽  
Hua Cong ◽  
Xu Huang
Keyword(s):  
Heart Valve ◽  
Heart Valves ◽  
Material Model ◽  
Von Mises Stress ◽  
Stress Distributions ◽  
Bioprosthetic Heart Valve ◽  
Element Analysis ◽  
Bioprosthetic Heart Valves ◽  
Diastolic Phase ◽  
Von Mises

In order to investigate the effect of material nonlinearity on the dynamic behavior of bioprosthetic heart valve, we establish the spherical, cylindrical and ellipsoidal leaflets models with the material model of Mooney-Rivlin. The mechanical behavior of bioprosthetic valve leaflet during diastolic phase is analyzed. The finite element analysis results show that the stress distributions of the ellipsoidal and spherical valve leaflets are comparatively reasonable. The ellipsoidal and spherical valve leaflets have the following advantages over the cylindrical leaflet valve, lower peak von-Mises stress, smaller stress concentration area, and relatively uniform stress distribution. This work is very helpful to manufacture reasonable shaped valvular leaflets，thus to prolong the lifetime of the bioprosthetic heart valve.

Dialdehyde pectin-crosslinked and hirudin-loaded decellularized porcine pericardium with improved matrix stability, enhanced anti-calcification and anticoagulant for bioprosthetic heart valves

2021 ◽  
Author(s):  
Mengyue Hu ◽  
Xu Peng ◽  
Yang Zhao ◽  
Xiaoshuang Yu ◽  
Can Cheng ◽  
...  
Keyword(s):  
Heart Valve ◽  
Heart Valves ◽  
Heart Valve Diseases ◽  
Bioprosthetic Heart Valves ◽  
Matrix Stability ◽  
Transcatheter Valve ◽  
Valve Diseases ◽  
Porcine Pericardium

To conveniently and effectively cure heart valve diseases or defects, combining with transcatheter valve technology, bioprosthetic heart valves (BHVs) originated from the decellularized porcine pericardium (D-PP) have been broadly used...

Large Displacement Flexural Properties of Tissue Engineered Heart Valve Scaffolds

2000 ◽  
Author(s):  
Michael S. Sacks ◽  
Sanjay Kaushal ◽  
John E. Mayer
Keyword(s):  
Heart Valve ◽  
Heart Valves ◽  
Critical Test ◽  
Bioprosthetic Heart Valves ◽  
Property Evaluation ◽  
Fundamental Information ◽  
Tissue Engineered Heart Valve ◽  
Valve Prostheses ◽  
Tissue Engineered Heart Valves

Abstract The need for improved heart valve prostheses is especially critical in pediatric applications, where growth and remodeling are essential. Tissue engineered heart valves (TEHV) have functioned in the pulmonary circulation of growing lambs for up to four months [1], and thus can potentially overcome limitations of current bioprosthetic heart valves. Despite these promising results, significant questions remain. In particular, the role of scaffold mechanical properties in optimal extra-cellular matrix development, as well as TEHV durability, are largely unexplored. We have previously demonstrated flexure testing as a sensitive and critical test for BHV tissue mechanical property evaluation [2]. The following study was conducted to determine the feasibility of using this technique to provide fundamental information required for optimizing TEHV scaffold designs.

scholarly journals PREDICTING HEART VALVE DYNAMICS WITH A FLUID-STRUCTURE INTERACTION MODEL

ASAIO Journal ◽  
2005 ◽  
Vol 51 (2) ◽  
pp. 3A
Author(s):  
Kris Dumont ◽  
Jan Vierendeels ◽  
Patrick Segers ◽  
Guido Van Nooten ◽  
Pascal Verdonck
Keyword(s):  
Heart Valve ◽  
Fluid Structure Interaction ◽  
Interaction Model ◽  
Fluid Structure ◽  
Structure Interaction ◽  
Valve Dynamics ◽  
Heart Valve Dynamics

Aortic valve dynamics using a fluid structure interaction model – The physiology of opening and closing

2015 ◽  
Vol 48 (10) ◽  
pp. 1737-1744 ◽  
Author(s):  
Govinda Balan Kalyana Sundaram ◽  
Komarakshi R. Balakrishnan ◽  
Ramarathnam Krishna Kumar
Keyword(s):  
Aortic Valve ◽  
Fluid Structure Interaction ◽  
Interaction Model ◽  
Fluid Structure ◽  
Structure Interaction ◽  
Valve Dynamics ◽  
Opening And Closing

scholarly journals Mechanics and Microstructure of the Atrioventricular Heart Valve Chordae Tendineae: A Review

2020 ◽  
Vol 7 (1) ◽  
pp. 25 ◽  
Author(s):  
Colton J. Ross ◽  
Junnan Zheng ◽  
Liang Ma ◽  
Yi Wu ◽  
Chung-Hao Lee
Keyword(s):  
Heart Valve ◽  
Heart Valves ◽  
Disease Recurrence ◽  
Tissue Mechanics ◽  
Papillary Muscles ◽  
Chordae Tendineae ◽  
Current State ◽  
Current Therapies ◽  
Opening And Closing ◽  
Valve Diseases

The atrioventricular heart valves (AHVs) are responsible for directing unidirectional blood flow through the heart by properly opening and closing the valve leaflets, which are supported in their function by the chordae tendineae and the papillary muscles. Specifically, the chordae tendineae are critical to distributing forces during systolic closure from the leaflets to the papillary muscles, preventing leaflet prolapse and consequent regurgitation. Current therapies for chordae failure have issues of disease recurrence or suboptimal treatment outcomes. To improve those therapies, researchers have sought to better understand the mechanics and microstructure of the chordae tendineae of the AHVs. The intricate structures of the chordae tendineae have become of increasing interest in recent literature, and there are several key findings that have not been comprehensively summarized in one review. Therefore, in this review paper, we will provide a summary of the current state of biomechanical and microstructural characterizations of the chordae tendineae, and also discuss perspectives for future studies that will aid in a better understanding of the tissue mechanics–microstructure linking of the AHVs’ chordae tendineae, and thereby improve the therapeutics for heart valve diseases caused by chordae failures.

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