A Comparison of the Mechanical Properties of the Goat Temporomandibular Joint Disc to the Mandibular Condylar Cartilage in Unconfined Compression

2011 ◽  
Author(s):  
Catherine K. Hagandora ◽  
Alejandro J. Almarza
Keyword(s):  
Temporomandibular Joint ◽  
Unconfined Compression ◽  
Compressive Behavior ◽  
Articular Eminence ◽  
Condylar Cartilage ◽  
Temporomandibular Joint Disc ◽  
Mandibular Condylar Cartilage ◽  
Structural Abnormalities ◽  
Tmj Disc

The temporomandibular joint (TMJ) is a synovial, bilateral joint formed by the articulation of the condyle of the mandible and the articular eminence and glenoid fossa of the temporal bone. The articulating tissues of the joint include the TMJ disc and the mandibular condylar cartilage (MCC). It is estimated that 10 million Americans are affected by TMJ disorders (TMDs), a term encompassing a variety of conditions which result in positional or structural abnormalities in the joint. [1] Characterization of the properties of the articulating tissues of the joint is a necessary prequel to understanding the process of pathogenesis as well as tissue engineering suitable constructs for replacement of damaged joint fibrocartilage. Furthermore, the current literature lacks a one-to-one comparison of the regional compressive behavior of the goat MCC to the TMJ disc.

scholarly journals Trueness of Fit of Biphasic Transversely Isotropic Parameters Model in the Porcine Temporomandibular Joint Disc and Mandibular Condylar Cartilage and Regional Dependence

2020 ◽  
Vol 142 (8) ◽  
Author(s):  
Adam R. Chin ◽  
Alejandro J. Almarza
Keyword(s):  
Temporomandibular Joint ◽  
Transversely Isotropic ◽  
Theoretical Models ◽  
Compressive Properties ◽  
Condylar Cartilage ◽  
Temporomandibular Joint Disc ◽  
Viscoelastic Parameters ◽  
Mandibular Condylar Cartilage ◽  
Tmj Disc ◽  
And Behavior

Abstract Temporomandibular joint (TMJ) disorders (TMDs) are not well understood and the mechanical differences between the regions of the mandibular condylar cartilage (MCC) and the TMJ disc have not been thoroughly compared. As of now, there are no commercially available regenerative therapies for the TMJ. Elucidating the mechanical properties of these two structures of the articulating joint will help future efforts in developing tissue engineering treatments of the TMJ. In this study, we evaluate the compressive properties of the porcine disc and mandibular condylar cartilage by performing unconfined compression at 10% strain with 4.5%/min strain rate. Punches (4 mm biopsy) from both tissues were taken from five different regions of both the MCC and TMJ: anterior, posterior, lateral, medial, and central. Previously, theoretical models of compression in the porcine tissue did not fit the whole ramp-relaxation behavior. Thus, the data stress–relaxation was fitted to the biphasic transversely isotropic model, for both the TMJ disc and cartilage. From the results found in the disc, it was found that the posterior region had the highest values in multiple viscoelastic parameters when compared to the other regions. The mandibular condylar cartilage was only found to be significantly different in the transverse modulus between the posterior and lateral regions. Both the TMJ disc and MCC had similar magnitudes of values (for the modulus and other corresponding compressive properties) and behavior under this testing modality.

Automated Indentation Demonstrates Structural Stiffness of Femoral Articular Cartilage and Temporomandibular Joint Mandibular Condylar Cartilage Is Altered in FgF2KO Mice

Cartilage ◽  
2020 ◽  
pp. 194760352096256
Author(s):  
Paige S. Woods ◽  
Alyssa A. Morin ◽  
Po-Jung Chen ◽  
Sarah Mahonski ◽  
Liping Xiao ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Temporomandibular Joint ◽  
Functional Characterization ◽  
Structural Stiffness ◽  
Motion Controller ◽  
Condylar Cartilage ◽  
Spatially Resolved ◽  
Mandibular Condylar Cartilage ◽  
Fgf2 Expression ◽  
Health And Disease

Objective Employ an automated indentation technique, using a commercially available machine, to assess the effect of fibroblast growth factor 2 (FGF2) expression on structural stiffness over the surface of both murine femoral articular cartilage (AC) and temporomandibular joint (TMJ) mandibular condylar cartilage (MCC). Design Experiments were performed using 3-month-old female homozygote Fgf2KO mice with wild type (WT) littermates. After euthanization, isolated mandibles and hindlimbs were either processed for histology or subjected to automated indentation on a Biomomentum Mach-1 v500csst with a 3-axis motion controller in a phosphate buffered saline bath using a 0.3 mm spherical tip indenter. The effect of indentation depth on normal force was characterized, then structural stiffness was calculated and mapped at multiple positions on the AC and MCC. Results Automated indentation of the AC and TMJ MCC was successfully completed and was able to demonstrate both regional variation in structural stiffness and differences between WT and Fgf2KO mice. Structural stiffness values for Fgf2KO AC were significantly smaller than WT at both the medial/anterior ( P < 0.05) and medial/posterior ( P < 0.05) positions. Global Fgf2KO also lead to a decrease in MCC thickness of the TMJ compared with WT ( P < 0.05) and increased structural stiffness values for Fgf2KO at both the posterior and anterior location ( P < 0.05). Conclusions Automated indentation spatially resolved differences in structural stiffness between WT and Fgf2KO tissue, demonstrating FGF2 expression affects femoral AC and TMJ MCC. This quantitative method will provide a valuable approach for functional characterization of cartilage tissues in murine models relevant to knee joint and TMJ health and disease.

scholarly journals Isolation and Characterization of Murine Mandibular Condylar Cartilage Cell Populations

2012 ◽  
Vol 195 (3) ◽  
pp. 232-243 ◽  
Author(s):  
J. Chen ◽  
A. Utreja ◽  
Z. Kalajzic ◽  
T. Sobue ◽  
D. Rowe ◽  
...  
Keyword(s):  
Cell Populations ◽  
Cartilage Cell ◽  
Condylar Cartilage ◽  
Isolation And Characterization ◽  
Mandibular Condylar Cartilage

The region-dependent dynamic properties of porcine temporomandibular joint disc under unconfined compression

2013 ◽  
Vol 46 (4) ◽  
pp. 845-848 ◽  
Author(s):  
Pelayo Fernández ◽  
María Jesús Lamela ◽  
Alberto Ramos ◽  
Alfonso Fernández-Canteli ◽  
Eiji Tanaka
Keyword(s):  
Temporomandibular Joint ◽  
Dynamic Properties ◽  
Unconfined Compression ◽  
Temporomandibular Joint Disc

scholarly journals Tensile Characterization of Porcine Temporomandibular Joint Disc Attachments

2013 ◽  
Vol 92 (8) ◽  
pp. 753-758 ◽  
Author(s):  
M.K. Murphy ◽  
B. Arzi ◽  
J.C. Hu ◽  
K.A. Athanasiou
Keyword(s):  
Temporomandibular Joint ◽  
Temporomandibular Joint Disc ◽  
Tensile Characterization

scholarly journals Tissue engineering toward temporomandibular joint disc regeneration

2018 ◽  
Vol 10 (446) ◽  
pp. eaaq1802 ◽  
Author(s):  
Natalia Vapniarsky ◽  
Le W. Huwe ◽  
Boaz Arzi ◽  
Meghan K. Houghton ◽  
Mark E. Wong ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Temporomandibular Joint ◽  
Treated Group ◽  
Defect Closure ◽  
Repair Tissue ◽  
Temporomandibular Joint Disc ◽  
Disc Regeneration ◽  
Tmj Disc ◽  
Engineering Strategy

Treatments for temporomandibular joint (TMJ) disc thinning and perforation, conditions prevalent in TMJ pathologies, are palliative but not reparative. To address this, scaffold-free tissue-engineered implants were created using allogeneic, passaged costal chondrocytes. A combination of compressive and bioactive stimulation regimens produced implants with mechanical properties akin to those of the native disc. Efficacy in repairing disc thinning was examined in minipigs. Compared to empty controls, treatment with tissue-engineered implants restored disc integrity by inducing 4.4 times more complete defect closure, formed 3.4-fold stiffer repair tissue, and promoted 3.2-fold stiffer intralaminar fusion. The osteoarthritis score (indicative of degenerative changes) of the untreated group was 3.0-fold of the implant-treated group. This tissue engineering strategy paves the way for developing tissue-engineered implants as clinical treatments for TMJ disc thinning.

Frictional Coefficient of TMJ Disc and Condylar Cartilage

2012 ◽  
Author(s):  
Edward D. Bonnevie ◽  
Laura Barito ◽  
Matthew Aldridge ◽  
Liyun Wang ◽  
David L. Burris ◽  
...  
Keyword(s):  
Temporomandibular Joint ◽  
Frictional Coefficient ◽  
Human Head ◽  
Daily Activities ◽  
Condylar Cartilage ◽  
Cartilaginous Tissues ◽  
Diarthrodial Joint ◽  
Composition And Structure ◽  
Tmj Disc ◽  
Frictional Coefficients

Temporomandibular joint (TMJ), the only diarthrodial joint in human head, is composed of two articulating bones covered by cartilage with an extra disc between the two cartilage surfaces. The rotation and gliding motions of TMJ allow us to talk, chew, and yawn. Dislocation of the disc or degeneration of the cartilage can severely ruin the congruity and integrality of TMJ and further leads to TMJ disorders (TMD). Histology studies showed that the composition and structure of condylar cartilage do not resemble any other fibrocartilages [1], our recent study also found that the condylar cartilage is much softer than cartilage in other joints [2]. The condyle is fully covered by the disc, which glides on the condyle cartilage during daily activities [3]. Little is known about the frictional coefficients of these cartilaginous tissues in TMJ. In this study, using a novel custom-built tribometer, we propose to investigate: 1) the frictional coefficients of condylar cartilage and disc at five different regions, and 2) the dependency of frictional coefficient on sliding speed and loading magnitude.

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