Retention and Transport of Hydrophobic and Hydrophilic Drug Surrogate Molecules in Coronary Arteries Measured Nondestructively With Photoacoustic Ultrasound

2013 ◽  
Author(s):  
Joseph T. Keyes ◽  
Leonardo G. Montilla ◽  
Russel S. Witte ◽  
Jonathan P. Vande Geest
Keyword(s):  
Drug Delivery ◽  
Real Time ◽  
Coronary Arteries ◽  
Local Drug Delivery ◽  
Drug Eluting Stents ◽  
Systemic Effects ◽  
Chemical Polarization ◽  
Design And Implementation ◽  
Hydrophilic Drug ◽  
Drug Eluting

The design and implementation of local drug delivery mechanisms in cardiovascular applications provides a method by which localized action can occur without potentially problematic systemic effects. This has been especially relevant in the case of drug-eluting stents (DESs). It has been previously shown that the degree of chemical polarization can significantly change the degree of transport and the degree of vascular retention of drugs. Understanding how these differences occur in real-time, and nondestructively, can better help guide the design of such pharmaceuticals. Previous work by our laboratory has indicated differences in transport based on location within the coronary tree (Fig. 1) [1].

Systems of local drug delivery to arterial wall for prevention of in-stent restenosis

2016 ◽  
Vol 4 ◽  
pp. 55-61
Author(s):  
Krzysztof Milewski ◽  
Anna Turek ◽  
Agata Krauze ◽  
Paweł Gąsior ◽  
Aleksandra Błachut ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bare Metal Stents ◽  
Alternative Methods ◽  
Local Drug Delivery ◽  
Drug Eluting Stents ◽  
Metal Stents ◽  
Very Late Stent Thrombosis ◽  
Stent Restenosis ◽  
Fast Development ◽  
Drug Eluting

New generation, drug-eluting stents used in the treatment of coronary and peripheral atherosclerotic disease (CPAD) significantly reduced restenosis and revascularization rates as well as frequency of thrombosis as compared to bare metal stents and first-generation drug eluting stents. However, despite fast development of this technology several reports have been published recently that describe cases of late and very late stent thrombosis, restenosis and neoatheroslerosis within arterial segments with previously implanted stents. For this reason many research are being conducted with the aim to design alternative methods for intra-arterial drugs delivery in order to reduce restenosis and revascularization rates, yet eliminating adverse effects mentioned above. One of possibilities is lipophilic and antiproliferative drug coated balloon technology, which offers high drug concentration in arterial tissue and restenotic effect in selected clinical situations despite the short balloon inflation time. A particularly interesting option is intra-arterial delivery of drugs with different mechanisms of action, regardless of their lipophilicity by loading them into biodegradable nanospheres. In this paper, currently used systems for local drug delivery have been described including their limitations and opportunities. In addition, we provided a brief description of the project sponsored by Polpharma Scientific Foundation, which aimed to evaluate potentials of local delivery of biodegradable nanospheres loaded with everolimus, which could be used to reduce restenosis rate after stent implantation.

Neointima Inhibition: Comparison of Effectiveness of Non–Stent-based Local Drug Delivery and a Drug-eluting Stent in Porcine Coronary Arteries

Radiology ◽  
2006 ◽  
Vol 240 (2) ◽  
pp. 411-418 ◽  
Author(s):  
Ulrich Speck ◽  
Bruno Scheller ◽  
Claudia Abramjuk ◽  
Christoph Breitwieser ◽  
Juergen Dobberstein ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Coronary Arteries ◽  
Local Drug Delivery ◽  
Drug Eluting Stent ◽  
Drug Eluting ◽  
Comparison Of Effectiveness

scholarly journals Drug-eluting embolic microspheres for local drug delivery – State of the art

2017 ◽  
Vol 262 ◽  
pp. 127-138 ◽  
Author(s):  
Katrin Fuchs ◽  
Rafael Duran ◽  
Alban Denys ◽  
Pierre E. Bize ◽  
Gerrit Borchard ◽  
...  
Keyword(s):  
Drug Delivery ◽  
State Of The Art ◽  
Local Drug Delivery ◽  
Drug Eluting

Transport in Pulsatile Axisymmetric Stented Arterial Models From Location-Dependent Variations in Permeability and Mechanical Properties

2011 ◽  
Author(s):  
Joseph T. Keyes ◽  
Bruce R. Simon ◽  
Jonathan P. Vande Geest
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Relative Influence ◽  
Drug Eluting Stents ◽  
Diffusive Transport ◽  
Antiproliferative Effects ◽  
Drug Eluting ◽  
Tissue System ◽  
Localized Drug Delivery ◽  
Insight Into

Drug-eluting stents (DESs) perform their antiproliferative effects through the use of localized drug delivery. The delivery may be computationally modeled to determine efficacy of the DES-tissue system and utilizes coupled convective and diffusive transport. Since the movement of solutes through the wall is via the coupled effects of convective and diffusive transport, the relative influence of these factors provides insight into the governing forces of localized DES drug delivery [1].

scholarly journals Optimization of Drug Delivery by Drug-Eluting Stents

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0130182 ◽  
Author(s):  
Franz Bozsak ◽  
David Gonzalez-Rodriguez ◽  
Zachary Sternberger ◽  
Paul Belitz ◽  
Thomas Bewley ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Eluting Stents ◽  
Drug Eluting
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