Transport in Pulsatile Axisymmetric Stented Arterial Models From Location-Dependent Variations in Permeability and Mechanical Properties

2011 ◽  
Author(s):  
Joseph T. Keyes ◽  
Bruce R. Simon ◽  
Jonathan P. Vande Geest
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Relative Influence ◽  
Drug Eluting Stents ◽  
Diffusive Transport ◽  
Antiproliferative Effects ◽  
Drug Eluting ◽  
Tissue System ◽  
Localized Drug Delivery ◽  
Insight Into

Drug-eluting stents (DESs) perform their antiproliferative effects through the use of localized drug delivery. The delivery may be computationally modeled to determine efficacy of the DES-tissue system and utilizes coupled convective and diffusive transport. Since the movement of solutes through the wall is via the coupled effects of convective and diffusive transport, the relative influence of these factors provides insight into the governing forces of localized DES drug delivery [1].

An insight into the current use of drug eluting stents in acute and elective percutaneous coronary interventions in Europe. A report on the EuroPCI Survey

10.4244/a78 ◽  
2008 ◽  
Vol 3 (4) ◽  
pp. 429-441 ◽  
Author(s):  
Steve Ramcharitar ◽  
Matthias Hochadel ◽  
Anne Gaster ◽  
Yoshinobu Onuma ◽  
Anselm Gitt ◽  
...  
Keyword(s):  
Drug Eluting Stents ◽  
Percutaneous Coronary Interventions ◽  
Coronary Interventions ◽  
Percutaneous Coronary ◽  
Drug Eluting ◽  
Insight Into

scholarly journals Optimization of Drug Delivery by Drug-Eluting Stents

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0130182 ◽  
Author(s):  
Franz Bozsak ◽  
David Gonzalez-Rodriguez ◽  
Zachary Sternberger ◽  
Paul Belitz ◽  
Thomas Bewley ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Eluting Stents ◽  
Drug Eluting

Systems of local drug delivery to arterial wall for prevention of in-stent restenosis

2016 ◽  
Vol 4 ◽  
pp. 55-61
Author(s):  
Krzysztof Milewski ◽  
Anna Turek ◽  
Agata Krauze ◽  
Paweł Gąsior ◽  
Aleksandra Błachut ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bare Metal Stents ◽  
Alternative Methods ◽  
Local Drug Delivery ◽  
Drug Eluting Stents ◽  
Metal Stents ◽  
Very Late Stent Thrombosis ◽  
Stent Restenosis ◽  
Fast Development ◽  
Drug Eluting

New generation, drug-eluting stents used in the treatment of coronary and peripheral atherosclerotic disease (CPAD) significantly reduced restenosis and revascularization rates as well as frequency of thrombosis as compared to bare metal stents and first-generation drug eluting stents. However, despite fast development of this technology several reports have been published recently that describe cases of late and very late stent thrombosis, restenosis and neoatheroslerosis within arterial segments with previously implanted stents. For this reason many research are being conducted with the aim to design alternative methods for intra-arterial drugs delivery in order to reduce restenosis and revascularization rates, yet eliminating adverse effects mentioned above. One of possibilities is lipophilic and antiproliferative drug coated balloon technology, which offers high drug concentration in arterial tissue and restenotic effect in selected clinical situations despite the short balloon inflation time. A particularly interesting option is intra-arterial delivery of drugs with different mechanisms of action, regardless of their lipophilicity by loading them into biodegradable nanospheres. In this paper, currently used systems for local drug delivery have been described including their limitations and opportunities. In addition, we provided a brief description of the project sponsored by Polpharma Scientific Foundation, which aimed to evaluate potentials of local delivery of biodegradable nanospheres loaded with everolimus, which could be used to reduce restenosis rate after stent implantation.

scholarly journals Modeling and Analysis of Drug-Eluting Stents With Biodegradable PLGA Coating: Consequences on Intravascular Drug Delivery

2014 ◽  
Vol 136 (11) ◽  
Author(s):  
Xiaoxiang Zhu ◽  
Richard D. Braatz
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Arterial Wall ◽  
Drug Distribution ◽  
Integrated Model ◽  
Drug Binding ◽  
Drug Eluting Stents ◽  
Drug Concentrations ◽  
Drug Eluting ◽  
Release Profiles

Increasing interests have been raised toward the potential applications of biodegradable poly(lactic-co-glycolic acid) (PLGA) coatings for drug-eluting stents in order to improve the drug delivery and reduce adverse outcomes in stented arteries in patients. This article presents a mathematical model to describe the integrated processes of drug release in a stent with PLGA coating and subsequent drug delivery, distribution, and drug pharmacokinetics in the arterial wall. The integrated model takes into account the PLGA degradation and erosion, anisotropic drug diffusion in the arterial wall, and reversible drug binding. The model simulations first compare the drug delivery from a biodegradable PLGA coating with that from a biodurable coating, including the drug release profiles in the coating, average arterial drug levels, and arterial drug distribution. Using the model for the PLGA stent coating, the simulations further investigate drug internalization, interstitial fluid flow in the arterial wall, and stent embedment for their impact on drug delivery. Simulation results show that these three factors, while imposing little change in the drug release profiles, can greatly change the average drug concentrations in the arterial wall. In particular, each of the factors leads to significant and yet distinguished alterations in the arterial drug distribution that can potentially influence the treatment outcomes. The detailed integrated model provides insights into the design and evaluation of biodegradable PLGA-coated drug-eluting stents for improved intravascular drug delivery.

scholarly journals A bilayer swellable drug-eluting ureteric stent: Localized drug delivery to treat urothelial diseases

Biomaterials ◽  
2018 ◽  
Vol 165 ◽  
pp. 25-38 ◽  
Author(s):  
Wei Shan Lim ◽  
Kenneth Chen ◽  
Tsung Wen Chong ◽  
Gordon Minru Xiong ◽  
William R. Birch ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ureteric Stent ◽  
Drug Eluting ◽  
Localized Drug Delivery

scholarly journals Smart Shear-Thinning Hydrogels as Injectable Drug Delivery Systems

Polymers ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1317 ◽  
Author(s):  
Sadaf Samimi Gharaie ◽  
Seyed Dabiri ◽  
Mohsen Akbari
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Total Solid ◽  
Shear Thinning ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Physiological Conditions ◽  
Optimum Formulation ◽  
Localized Drug Delivery ◽  
Sensitive Behavior

In this study, we fabricated and characterized a smart shear-thinning hydrogel composed of gelatin and laponite for localized drug delivery. We added chitosan (Chi) and poly N-isopropylacrylamide-co-Acrylic acid (PNIPAM) particles to the shear-thinning gel to render it pH-responsive. The effects of total solid weight and the percentage of laponite in a solid mass on the rheological behavior and mechanical properties were investigated to obtain the optimum formulation. The nanocomposite gel and particles were characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), zeta potential, and dynamic light scattering techniques. Finally, release related experiment including degradability, swelling and Rhodamine B (Rd) release at various pH were performed. The results suggest that incorporation of silicate nanoplatelets in the gelatin led to the formation of the tunable porous composite, with a microstructure that was affected by introducing particles. Besides, the optimum formulation possessed shear-thinning properties with modified rheological and mechanical properties which preserved its mechanical properties while incubated in physiological conditions. The release related experiments showed that the shear-thinning materials offer pH-sensitive behavior so that the highest swelling ratio, degradation rate, and Rd release were obtained at pH 9.18. Therefore, this nanocomposite gel can be potentially used to develop pH-sensitive systems.

Non-vascular drug eluting stents as localized controlled drug delivery platform: Preclinical and clinical experience

2013 ◽  
Vol 172 (1) ◽  
pp. 105-117 ◽  
Author(s):  
Mohsin Shaikh ◽  
Ganessan Kichenadasse ◽  
Namita Roy Choudhury ◽  
Ross Butler ◽  
Sanjay Garg
Keyword(s):  
Drug Delivery ◽  
Clinical Experience ◽  
Controlled Drug Delivery ◽  
Drug Eluting Stents ◽  
Drug Eluting ◽  
Delivery Platform

Retention and Transport of Hydrophobic and Hydrophilic Drug Surrogate Molecules in Coronary Arteries Measured Nondestructively With Photoacoustic Ultrasound

2013 ◽  
Author(s):  
Joseph T. Keyes ◽  
Leonardo G. Montilla ◽  
Russel S. Witte ◽  
Jonathan P. Vande Geest
Keyword(s):  
Drug Delivery ◽  
Real Time ◽  
Coronary Arteries ◽  
Local Drug Delivery ◽  
Drug Eluting Stents ◽  
Systemic Effects ◽  
Chemical Polarization ◽  
Design And Implementation ◽  
Hydrophilic Drug ◽  
Drug Eluting

The design and implementation of local drug delivery mechanisms in cardiovascular applications provides a method by which localized action can occur without potentially problematic systemic effects. This has been especially relevant in the case of drug-eluting stents (DESs). It has been previously shown that the degree of chemical polarization can significantly change the degree of transport and the degree of vascular retention of drugs. Understanding how these differences occur in real-time, and nondestructively, can better help guide the design of such pharmaceuticals. Previous work by our laboratory has indicated differences in transport based on location within the coronary tree (Fig. 1) [1].

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