Confocal Raman spectroscopic analysis of cross-linked ultra-high molecular weight polyethylene for application in artificial hip joints

2007 ◽  
Vol 12 (1) ◽  
pp. 014011 ◽  
Author(s):  
Giuseppe Pezzotti ◽  
Tsuyoshi Kumakura ◽  
Kiyotaka Yamada ◽  
Toshiyuki Tateiwa ◽  
Leonardo Puppulin ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Spectroscopic Analysis ◽  
Hip Joints ◽  
Raman Spectroscopic ◽  
Artificial Hip ◽  
Confocal Raman ◽  
Artificial Hip Joints ◽  
Ultra High Molecular Weight ◽  
Raman Spectroscopic Analysis

Confocal Raman Spectroscopic Analysis of Ceramic Hip Joints

2006 ◽  
Vol 309-311 ◽  
pp. 1211-1214 ◽  
Author(s):  
Giuseppe Pezzotti ◽  
Ian C. Clarke ◽  
C. Jobe ◽  
T. Donaldson ◽  
Kengo Yamamoto ◽  
...  
Keyword(s):  
Hip Arthroplasty ◽  
Spectroscopic Analysis ◽  
Spectroscopic Techniques ◽  
Hip Joints ◽  
Raman Spectroscopic ◽  
Joint Surfaces ◽  
Artificial Hip ◽  
Confocal Raman ◽  
Artificial Hip Joints ◽  
Raman Spectroscopic Analysis

A survey of confocal Raman/fluorescence microprobe spectroscopic techniques is presented with emphasis placed on surface analysis of artificial hip joints. Suitable instrumental configurations are first explained in some details in order to describe the versatility of the spectroscopic microprobes to biomedical materials analyses. Then, these notions, which represent the foundation for structural and mechanical analyses of joint surfaces, are applied to selected cases of paramount importance in hip arthroplasty.

The influence of phospholipid concentration in protein-containing lubricants on the wear of ultra-high molecular weight polyethylene in artificial hip joints

2001 ◽  
Vol 215 (2) ◽  
pp. 259-263 ◽  
Author(s):  
J Bell ◽  
J L Tipper ◽  
E Ingham ◽  
M H Stone ◽  
J Fisher
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Phosphatidyl Choline ◽  
Bovine Serum ◽  
Hip Joints ◽  
Wear Rates ◽  
Artificial Hip ◽  
Artificial Hip Joints ◽  
Ultra High Molecular Weight

There is considerable interest in the wear of polyethylene and the resulting wear-debrisinduced osteolysis in artificial hip joints. Proteins play an important role as boundary lubricants in vivo in the pseudosynovial fluid, and these are reproduced in in vitro tests through the use of bovine serum. Little is known, however, about the effect of phospholipid concentrations within proteinaceous solutions on the wear of ultra-high molecular weight polyethylene (UHMWPE). The effects of protein-containing lubricants with 0.05, 0.5 and 5 per cent (w/v) phosphatidyl choline concentrations on the wear of ultra-high molecular weight polyethylene (UHMWPE) were compared with 25 per cent (v/v) bovine serum which had 0.01 per cent (w/v) lipid; the effects were compared in a hip joint simulator with smooth (n = 4) and scratched (n = 3) femoral heads. The control bovine serum lubricant produced UHWMPE wear of 55 and 115mm3/106 cycles on the smooth and rough heads respectively. The increased phospholipid concentration significantly reduced the wear rate. At the higher concentration (5% w/v phosphatidyl choline) the average wear was reduced to less than 2 mm3/106 cycles. Even with the relatively low concentrations of 0.05% w/v phosphatidyl choline the wear was reduced by at least threefold compared with the bovine serum tests for both the smooth and rough femoral heads. There may be considerable differences in the phospholipid concentrations in patients' synovial fluid and this is highly likely to produce considerable variation in wear rates. In vitro, differences in the phospholipid concentration of lubricants may also cause variation in wear rates between different simulator tests.

Confocal Raman Spectroscopic Analysis of Ceramic Hip Joints

2006 ◽  
pp. 1211-1214
Author(s):  
Giuseppe Pezzotti ◽  
Ian C. Clarke ◽  
C. Jobe ◽  
T. Donaldson ◽  
K. Yamamoto ◽  
...  
Keyword(s):  
Spectroscopic Analysis ◽  
Hip Joints ◽  
Raman Spectroscopic ◽  
Confocal Raman ◽  
Raman Spectroscopic Analysis

scholarly journals Raman spectroscopic analysis of high molecular weight proteins in solution – considerations for sample analysis and data pre-processing

The Analyst ◽  
2018 ◽  
Vol 143 (24) ◽  
pp. 5987-5998 ◽  
Author(s):  
Drishya Rajan Parachalil ◽  
Brenda Brankin ◽  
Jennifer McIntyre ◽  
Hugh J. Byrne
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Multivariate Regression ◽  
Spectroscopic Analysis ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Sample Analysis ◽  
Raman Spectroscopic ◽  
Regression Techniques ◽  
High Molecular Weight Proteins

This study explores the potential of Raman spectroscopy, coupled with multivariate regression techniques and ion exchange chromatography, to quantitatively monitor diagnostically relevant changes in high molecular weight proteins in liquid plasma.

A Bipolar Artificial Hip Joint Design for Contact Impingement Reduction

2015 ◽  
Vol 1123 ◽  
pp. 164-168 ◽  
Author(s):  
Eko Saputra ◽  
Iwan Budiwan Anwar ◽  
J. Jamari ◽  
Emile van der Heide
Keyword(s):  
Molecular Weight ◽  
Range Of Motion ◽  
High Molecular Weight ◽  
Internal Rotation ◽  
Hip Joint ◽  
Acetabular Liner ◽  
Free Range ◽  
Artificial Hip Joint ◽  
Artificial Hip ◽  
Ultra High Molecular Weight

The acetabular liner of an artificial hip joint (AHJ) is easily damaged locally in case of impingement, i.e. in case of contact of the liner wall with the stem neck, especially when it is made from relatively soft material such as ultra high molecular weight polyethylene (UHMWPE). Frequent impingement will severely damage the acetabular liner, requiring replacement of the AHJ. The aim of this study is to reduce AHJ impingement for specific combinations of flexion, internal rotation, and adduction of the thigh, by optimizing the design of the AHJ. The presented new design is based on modifying a conventional AHJ into a bipolar version with a higher free range of motion (RoM). Results show that the proposed design is able to prevent impingement for RoM. The latter range of motion corresponds well with the requirements of Shalat.

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