X-ray induced acoustic computed tomography with a conventional x-ray contrast agent

AbstractAim: In the current study, some imaging characteristics of AuNPs were quantitatively analyzed and compared with two conventional contrast media (CM) including Iodine and Gadolinium by using of a cylindrical phantom.Methods: AuNPs were synthesized with the mean diameter of 16 nm and were equalized to the concentration of 0.5, 1, 2 and 4 mg/mL in the same volumes. A cylindrical phantom resembling the head and neck was fabricated and drilled to contain small tubes filled with Iodine, Gadolinium, and AuNPs as contrast media. The phantom was scanned in different exposure techniques and CT numbers of three studied contrast media inside test tubes were measured in terms of Hounsfield Unit (HU). The imaging parameters of the noise and contrast to noise ratios (CNR) were calculated for all studied CMs.Results: AuNPs showed 128% and 166% higher CT number in comparison with Iodine and Gadolinium respectively. Also, Iodine had a greater CT number than Gadolinium for the same exposure techniques and concentration. The maximum CT number for AuNPs and studied contrast materials was obtained at the highest mAs and the lowest tube potential. The maximum CT number were 1033±11 (HU) for AuNP, 565±10 (HU) for Iodine, 458±11 for Gadolinium. Moreover, the maximum CNRs of 433±117, 203±53, 145±37 were found for AuNPs, Iodine and Gadolinium respectively.Conclusion: The contrast agent based on AuNPs showed higher imaging quality in terms of contrast and noise relative to other iodine and gadolinium based contrast media in X-ray computed tomography. Application of the AuNPs as a contrast medium in x-ray CT is recommended.

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X-ray differential phase contrast and dark-field computed tomography and radiography with microbubbles as contrast agent

2013 IEEE 10th International Symposium on Biomedical Imaging ◽

10.1109/isbi.2013.6556757 ◽

2013 ◽

Cited By ~ 2

Author(s):

Xiangyang Tang ◽

Yi Yang

Keyword(s):

Computed Tomography ◽

Contrast Agent ◽

Phase Contrast ◽

Dark Field ◽

X Ray ◽

Differential Phase ◽

Differential Phase Contrast

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In Situ X-ray-induced Acoustic Computed Tomography with a Contrast Agent: A Proof of Concept

Optics Letters ◽

10.1364/ol.447618 ◽

2021 ◽

Author(s):

Seongwook Choi ◽

Sinyoung Park ◽

Ayoung Pyo ◽

Dong-Yeon Kim ◽

Jung-Joon Min ◽

...

Keyword(s):

Computed Tomography ◽

Contrast Agent ◽

Proof Of Concept ◽

X Ray

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K-edge Subtraction Computed Tomography with a Compact Synchrotron X-ray Source

Scientific Reports ◽

10.1038/s41598-019-49899-z ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 2

Author(s):

Stephanie Kulpe ◽

Martin Dierolf ◽

Benedikt Günther ◽

Madleen Busse ◽

Klaus Achterhold ◽

...

Keyword(s):

Computed Tomography ◽

Contrast Agent ◽

Imaging Techniques ◽

X Rays ◽

Synchrotron Source ◽

X Ray ◽

Inverse Compton Scattering ◽

Inverse Compton ◽

X Ray Computed ◽

Compact Light Source

Abstract In clinical diagnosis, X-ray computed tomography (CT) is one of the most important imaging techniques. Yet, this method lacks the ability to differentiate similarly absorbing substances like commonly used iodine contrast agent and calcium which is typically seen in calcifications, kidney stones and bones. K-edge subtraction (KES) imaging can help distinguish these materials by subtracting two CT scans recorded at different X-ray energies. So far, this method mostly relies on monochromatic X-rays produced at large synchrotron facilities. Here, we present the first proof-of-principle experiment of a filter-based KES CT method performed at a compact synchrotron X-ray source based on inverse-Compton scattering, the Munich Compact Light Source (MuCLS). It is shown that iodine contrast agent and calcium can be clearly separated to provide CT volumes only showing one of the two materials. These results demonstrate that KES CT at a compact synchrotron source can become an important tool in pre-clinical research.

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Low-dose exposure energy-resolved X-ray computed tomography using a contrast agent with a high-energy K-edge

Journal of Nuclear Science and Technology ◽

10.1080/00223131.2013.849621 ◽

2013 ◽

Vol 51 (1) ◽

pp. 91-97 ◽

Cited By ~ 8

Author(s):

Yoshiki Yamashita ◽

Kazunari Shima ◽

Ikuo Kanno ◽

Masahiko Ohtaka ◽

Makoto Hashimoto ◽

...

Keyword(s):

Computed Tomography ◽

Contrast Agent ◽

Low Dose ◽

High Energy ◽

X Ray ◽

X Ray Computed ◽

Exposure Energy

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A High-Performance Ytterbium-Based Nanoparticulate Contrast Agent for In Vivo X-Ray Computed Tomography Imaging

Angewandte Chemie ◽

10.1002/ange.201106686 ◽

2011 ◽

Vol 124 (6) ◽

pp. 1466-1471 ◽

Cited By ~ 15

Author(s):

Yanlan Liu ◽

Kelong Ai ◽

Jianhua Liu ◽

Qinghai Yuan ◽

Yangyang He ◽

...

Keyword(s):

Computed Tomography ◽

Contrast Agent ◽

High Performance ◽

Computed Tomography Imaging ◽

X Ray ◽

Tomography Imaging ◽

X Ray Computed

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Optimal Contrast Agent Staining of Ligaments and Tendons for X-Ray Computed Tomography

PLoS ONE ◽

10.1371/journal.pone.0153552 ◽

2016 ◽

Vol 11 (4) ◽

pp. e0153552 ◽

Cited By ~ 27

Author(s):

Richard Balint ◽

Tristan Lowe ◽

Tom Shearer

Keyword(s):

Computed Tomography ◽

Contrast Agent ◽

X Ray ◽

X Ray Computed

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Facile Fabrication of BiF3: Ln (Ln = Gd, Yb, Er)@PVP Nanoparticles for High-Efficiency Computed Tomography Imaging

Nanoscale Research Letters ◽

10.1186/s11671-021-03591-2 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Jun Xie ◽

Zonglang Zhou ◽

Sihan Ma ◽

Xian Luo ◽

Jiajing Liu ◽

...

Keyword(s):

Computed Tomography ◽

Oral Administration ◽

Contrast Agent ◽

Contrast Agents ◽

Ct Imaging ◽

Average Particle ◽

Gi Tract ◽

X Ray ◽

Ct Value ◽

Ct Contrast

AbstractX-ray computed tomography (CT) has been widely used in clinical practice, and contrast agents such as Iohexol are often used to enhance the contrast of CT imaging between normal and diseased tissue. However, such contrast agents can have some toxicity. Thus, new CT contrast agents are urgently needed. Owing to the high atomic number (Z = 83), low cost, good biological safety, and great X-ray attenuation property (5.74 cm2 kg−1 at 100 keV), bismuth has gained great interest from researchers in the field of nano-sized CT contrast agents. Here, we synthesized BiF3: Ln@PVP nanoparticles (NPs) with an average particle size of about 380 nm. After coating them with polyvinylpyrrolidone (PVP), the BiF3: Ln@PVP NPs possessed good stability and great biocompatibility. Meanwhile, compared with the clinical contrast agent Iohexol, BiF3: Ln@PVP NPs showed superior in vitro CT imaging contrast. Subsequently, after in situ injection with BiF3: Ln@PVP NPs, the CT value of the tumor site after the injection was significantly higher than that before the injection (the CT value of the pre-injection and post-injection was 48.9 HU and 194.58 HU, respectively). The morphology of the gastrointestinal (GI) tract can be clearly observed over time after oral administration of BiF3: Ln@PVP NPs. Finally, the BiF3: Ln@PVP NPs were completely discharged from the GI tract of mice within 48 h of oral administration with no obvious damage to the GI tract. In summary, our easily synthesized BiF3: Ln@PVP NPs can be used as a potential clinical contrast agent and may have broad application prospects in CT imaging.

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