3D-Imaging and quantification of collagen networks in mammary tumors on different size scales

2021 ◽  
Author(s):  
Hannes Kamin ◽  
Lena Nolte ◽  
Jochen Maurer ◽  
Andreas Bleilevens ◽  
Elmar Stickeler ◽  
...  
Cancer Cell ◽  
2019 ◽  
Vol 35 (6) ◽  
pp. 953 ◽  
Author(s):  
Anne C. Rios ◽  
Bianca D. Capaldo ◽  
François Vaillant ◽  
Bhupinder Pal ◽  
Ravian van Ineveld ◽  
...  

Cancer Cell ◽  
2019 ◽  
Vol 35 (4) ◽  
pp. 618-632.e6 ◽  
Author(s):  
Anne C. Rios ◽  
Bianca D. Capaldo ◽  
François Vaillant ◽  
Bhupinder Pal ◽  
Ravian van Ineveld ◽  
...  

Author(s):  
P. J. Melnick ◽  
J. W. Cha ◽  
E. Samouhos

Spontaneous mammary tumors in females of a high tumor strain of C3H mice were cut into small fragments that were Implanted into the subcutaneous tissue of the back of males of the same strain, where they grew as transplantable tumors. When about Cm. In diameter daily fractional radiation was begun, applied to the tumors, the rest of the body being shielded by a lead shield. Two groups were treated with 150 and 200 r X-ray dally, of half value layer 0.6mm. copper; a third group was treated with 500 r cobalt radiation dally. The primary purpose was to examine the enzyme changes during radiation, with histochemlcal technics.


Author(s):  
Neil Rowlands ◽  
Jeff Price ◽  
Michael Kersker ◽  
Seichi Suzuki ◽  
Steve Young ◽  
...  

Three-dimensional (3D) microstructure visualization on the electron microscope requires that the sample be tilted to different positions to collect a series of projections. This tilting should be performed rapidly for on-line stereo viewing and precisely for off-line tomographic reconstruction. Usually a projection series is collected using mechanical stage tilt alone. The stereo pairs must be viewed off-line and the 60 to 120 tomographic projections must be aligned with fiduciary markers or digital correlation methods. The delay in viewing stereo pairs and the alignment problems in tomographic reconstruction could be eliminated or improved by tilting the beam if such tilt could be accomplished without image translation.A microscope capable of beam tilt with simultaneous image shift to eliminate tilt-induced translation has been investigated for 3D imaging of thick (1 μm) biologic specimens. By tilting the beam above and through the specimen and bringing it back below the specimen, a brightfield image with a projection angle corresponding to the beam tilt angle can be recorded (Fig. 1a).


Author(s):  
EA Rodegerdts ◽  
A Boss ◽  
K Riemarzik ◽  
M Lichy ◽  
F Schick ◽  
...  
Keyword(s):  
3 Tesla ◽  

2018 ◽  
Vol 2018 (1) ◽  
pp. 151-156
Author(s):  
Scott Geffert ◽  
Daniel Hausdorf ◽  
Joseph Coscia ◽  
Oi-Cheong Lee ◽  
Dahee Han ◽  
...  

Author(s):  
Deepak Goyal

Abstract Next generation assembly/package development challenges are primarily increased interconnect complexity and density with ever shorter development time. The results of this trend present some distinct challenges for the analytical tools/techniques to support this technical roadmap. The key challenge in the analytical tools/techniques is the development of non-destructive imaging for improved time to information. This paper will present the key drivers for the non-destructive imaging, results of literature search and evaluation of key analytical techniques currently available. Based on these studies requirements of a 3D imaging capability will be discussed. Critical breakthroughs required for development of such a capability are also summarized.


Author(s):  
Halit Dogan ◽  
Md Mahbub Alam ◽  
Navid Asadizanjani ◽  
Sina Shahbazmohamadi ◽  
Domenic Forte ◽  
...  

Abstract X-ray tomography is a promising technique that can provide micron level, internal structure, and three dimensional (3D) information of an integrated circuit (IC) component without the need for serial sectioning or decapsulation. This is especially useful for counterfeit IC detection as demonstrated by recent work. Although the components remain physically intact during tomography, the effect of radiation on the electrical functionality is not yet fully investigated. In this paper we analyze the impact of X-ray tomography on the reliability of ICs with different fabrication technologies. We perform a 3D imaging using an advanced X-ray machine on Intel flash memories, Macronix flash memories, Xilinx Spartan 3 and Spartan 6 FPGAs. Electrical functionalities are then tested in a systematic procedure after each round of tomography to estimate the impact of X-ray on Flash erase time, read margin, and program operation, and the frequencies of ring oscillators in the FPGAs. A major finding is that erase times for flash memories of older technology are significantly degraded when exposed to tomography, eventually resulting in failure. However, the flash and Xilinx FPGAs of newer technologies seem less sensitive to tomography, as only minor degradations are observed. Further, we did not identify permanent failures for any chips in the time needed to perform tomography for counterfeit detection (approximately 2 hours).


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