Early recognition of Alzheimer's disease in EEG using recurrent neural network and wavelet transform

Author(s):  
Arthur A. Petrosian ◽  
Danil Prokhorov ◽  
Randolph B. Schiffer
2001 ◽  
Vol 112 (8) ◽  
pp. 1378-1387 ◽  
Author(s):  
A.A. Petrosian ◽  
D.V. Prokhorov ◽  
W. Lajara-Nanson ◽  
R.B. Schiffer

Sensors ◽  
2020 ◽  
Vol 20 (24) ◽  
pp. 7212
Author(s):  
Jungryul Seo ◽  
Teemu H. Laine ◽  
Gyuhwan Oh ◽  
Kyung-Ah Sohn

As the number of patients with Alzheimer’s disease (AD) increases, the effort needed to care for these patients increases as well. At the same time, advances in information and sensor technologies have reduced caring costs, providing a potential pathway for developing healthcare services for AD patients. For instance, if a virtual reality (VR) system can provide emotion-adaptive content, the time that AD patients spend interacting with VR content is expected to be extended, allowing caregivers to focus on other tasks. As the first step towards this goal, in this study, we develop a classification model that detects AD patients’ emotions (e.g., happy, peaceful, or bored). We first collected electroencephalography (EEG) data from 30 Korean female AD patients who watched emotion-evoking videos at a medical rehabilitation center. We applied conventional machine learning algorithms, such as a multilayer perceptron (MLP) and support vector machine, along with deep learning models of recurrent neural network (RNN) architectures. The best performance was obtained from MLP, which achieved an average accuracy of 70.97%; the RNN model’s accuracy reached only 48.18%. Our study results open a new stream of research in the field of EEG-based emotion detection for patients with neurological disorders.


2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Debesh Jha ◽  
Ji-In Kim ◽  
Goo-Rak Kwon

Background. Error-free diagnosis of Alzheimer’s disease (AD) from healthy control (HC) patients at an early stage of the disease is a major concern, because information about the condition’s severity and developmental risks present allows AD sufferer to take precautionary measures before irreversible brain damage occurs. Recently, there has been great interest in computer-aided diagnosis in magnetic resonance image (MRI) classification. However, distinguishing between Alzheimer’s brain data and healthy brain data in older adults (age > 60) is challenging because of their highly similar brain patterns and image intensities. Recently, cutting-edge feature extraction technologies have found extensive application in numerous fields, including medical image analysis. Here, we propose a dual-tree complex wavelet transform (DTCWT) for extracting features from an image. The dimensionality of feature vector is reduced by using principal component analysis (PCA). The reduced feature vector is sent to feed-forward neural network (FNN) to distinguish AD and HC from the input MR images. These proposed and implemented pipelines, which demonstrate improvements in classification output when compared to that of recent studies, resulted in high and reproducible accuracy rates of 90.06 ± 0.01% with a sensitivity of 92.00 ± 0.04%, a specificity of 87.78 ± 0.04%, and a precision of 89.6 ± 0.03% with 10-fold cross-validation.


2021 ◽  
Vol 19 (7) ◽  
pp. 84-95
Author(s):  
M. Anitha ◽  
V. Karpagam ◽  
P. Tamije Selvy

Alzheimer’s Disease (AD) is a serious disease that destroys brain and is classified as the most widespread type of dementia. Manual evaluation of image scans relies on visual reading and semi-quantitative investigation of various human brain sections, leading to wrong diagnoses. Neuroimaging plays a significant part in AD detection, using image processing approaches that succeed the drawback of traditional diagnosis methods. Feature extraction is done through Wavelet Transform (WT). Feature selection is an important step in machine learning, where best features set from all possible features is determined. Mutual Information based feature selection (MI) and Correlation-based Feature Selection (CFS) captures the ‘correlation’ between random variables. Machine Learning techniques are broadly used in a classification problem, as it is simple, effective mechanisms and capability to train to contribute intelligence to the arrangement. Classifiers used in this proposed work are Artificial Neural Network (ANN), Random Forest, Convolutional Neural Network (CNN), and Wavelet-based CNN. The superior ability of ANN is high-speed processing achieved through extensive parallel implementation, and this has emphasized necessity of research in this field. CNN has encouraged tackling this issue. This work proves that wavelet-based CNN performs better with a classification accuracy of 91.87%, the sensitivity of 0.94 for normal brain and 0.88 for AD affected brain, the positive predictive value of 0.91 for normal brain and 0.92 for AD affected brain, and F measure of 0.92 for normal brain and 0.90 for AD affected brain on ADNI MRI dataset of the human brain in detecting AD.


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