Biomechanical modeling of the three-dimensional aspects of human vocal fold dynamics

When developing high-fidelity computational model of vocal fold vibration for voice production of individuals, one would run into typical issues of unknown model parameters and model validation of individual-specific characteristics of phonation. In the current study, the evoked rabbit phonation is adopted to explore some of these issues. In particular, the mechanical properties of the rabbit's vocal fold tissue are unknown for individual subjects. In the model, we couple a 3D vocal fold model that is based on the magnetic resonance (MR) scan of the rabbit larynx and a simple one-dimensional (1D) model for the glottal airflow to perform fast simulations of the vocal fold dynamics. This hybrid three-dimensional (3D)/1D model is then used along with the experimental measurement of each individual subject for determination of the vocal fold properties. The vibration frequency and deformation amplitude from the final model are matched reasonably well for individual subjects. The modeling and validation approaches adopted here could be useful for future development of subject-specific computational models of vocal fold vibration.

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Developmental derivation of vocal fold mucosa from human induced pluripotent stem cells

10.21203/rs.2.12611/v1 ◽

2019 ◽

Author(s):

Vlasta Lungova ◽

Susan Thibeault

Keyword(s):

Epithelial Cells ◽

Pluripotent Stem Cells ◽

Vocal Fold ◽

Fluorescent Protein ◽

Three Dimensional ◽

Stratified Squamous Epithelium ◽

Three Dimensional Models ◽

Induced Pluripotent ◽

Green Fluorescent

Abstract Development of treatments for vocal dysphonia has been inhibited by lack of human vocal fold (VF) mucosa models because of difficulty in procuring VF epithelial cells, epithelial cells’ limited proliferative capacity and absence of cell lines. We report development of engineered VF mucosae from hiPSC, transfected via TALEN constructs for green fluorescent protein, that mimic development of VF epithelial cells in utero. Modulation of FGF signaling achieves stratified squamous epithelium from definitive and anterior foregut derived cultures. Robust culturing of these cells on collagen-fibroblast constructs produces three-dimensional models comparable to in vivo VF mucosa.

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Vocal Fold and Arytenoid Cartilage Motion During Inspiration and Phonation After Three-Dimensional Reconstruction of Dynamic CT

10.1055/s-0039-1686617 ◽

2019 ◽

Author(s):

P Zhuang ◽

H Bao ◽

D Piotrowski ◽

Z Zhang ◽

G Cai ◽

...

Keyword(s):

Vocal Fold ◽

Three Dimensional ◽

Arytenoid Cartilage ◽

Dynamic Ct ◽

Three Dimensional Reconstruction ◽

Dimensional Reconstruction

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Nonlinear Vocal Fold Dynamics in a Two-Mass Model of Speech Arising From Asymmetric Intraglottal Flow

ASME 2011 Summer Bioengineering Conference, Parts A and B ◽

10.1115/sbc2011-53952 ◽

2011 ◽

Author(s):

Byron D. Erath ◽

Matías Zañartu ◽

Sean D. Peterson ◽

Michael W. Plesniak

Keyword(s):

Vocal Fold ◽

Vocal Tract ◽

Vocal Folds ◽

Attractive Alternative ◽

Nonlinear Phenomena ◽

Mass Model ◽

Sustained Oscillations ◽

Voiced Speech ◽

Subglottal Pressure ◽

Vocal Fold Dynamics

Voiced speech is initiated as air is expelled from the lungs and passes through the vocal tract inciting self-sustained oscillations of the vocal folds. While various approaches exist for investigating both normal and pathological speech, the relative inaccessibility of the vocal folds make multi-mass speech models an attractive alternative. Their behavior has been benchmarked with excised larynx experiments, and they have been used as analysis tools for both normal and disordered speech, including investigations of paralysis, vocal tremor, and breathiness. However, during pathological speech, vocal fold motion is often unstructured, resulting in chaotic motion and a wealth of nonlinear phenomena. Unfortunately, current methodologies for multi-mass speech models are unable to replicate the nonlinear vocal fold behavior that often occurs in physiological diseased voice for realistic values of subglottal pressure.

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Model based comparison of vocal fold dynamics between children and adults

The Journal of the Acoustical Society of America ◽

10.1121/1.4933633 ◽

2015 ◽

Vol 138 (3) ◽

pp. 1779-1779 ◽

Cited By ~ 1

Author(s):

Michael Döllinger ◽

Denis Dubrovskiy ◽

Eva Beck ◽

Rita Patel

Keyword(s):

Vocal Fold ◽

Model Based ◽

Vocal Fold Dynamics

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Three-Dimensional Anatomic Characterization of the Canine Laryngeal Abductor and Adductor Musculature

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348940010900512 ◽

2000 ◽

Vol 109 (5) ◽

pp. 505-513 ◽

Cited By ~ 12

Author(s):

Corey W. Mineck ◽

Roger Chan ◽

Niro Tayama ◽

Ingo R. Titze

Keyword(s):

Vocal Fold ◽

Dimensional Space ◽

Three Dimensional ◽

Cross Sectional ◽

3 Dimensional ◽

Moment Arms ◽

Intrinsic Laryngeal Muscle ◽

Posterior Cricoarytenoid ◽

Intrinsic Laryngeal Muscles

The biomechanics of vocal fold abduction and adduction during phonation, respiration, and airway protection are not completely understood. Specifically, the rotational and translational forces on the arytenoid cartilages that result from intrinsic laryngeal muscle contraction have not been fully described. Anatomic data on the lines of action and moment arms for the intrinsic laryngeal muscles are also lacking. This study was conducted to quantify the 3-dimensional orientations and the relative cross-sectional areas of the intrinsic abductor and adductor musculature of the canine larynx. Eight canine larynges were used to evaluate the 3 muscles primarily responsible for vocal fold abduction and adduction: the posterior cricoarytenoid, the lateral cricoarytenoid, and the interarytenoid muscles. Each muscle was exposed and divided into discrete fiber bundles whose coordinate positions were digitized in 3-dimensional space. The mass, length, relative cross-sectional area, and angle of orientation for each muscle bundle were obtained to allow for the calculations of average lines of action and moment arms for each muscle. This mapping of the canine laryngeal abductor and adductor musculature provides important anatomic data for use in laryngeal biomechanical modeling. These data may also be useful in surgical procedures such as arytenoid adduction.

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