A Practical Strain Sensor Based on Ecoflex/Overlapping Graphene/Ecoflex Sandwich Structures for Vocal Fold Vibration and Body Motion Monitoring

Graphene-based stretchable and flexible strain sensors are one of the promising “bridges” to the biomedical realm. However, enhancing graphene-based wearable strain sensors to meet the demand of high sensitivity, broad sensing range, and recoverable structure deformation simultaneously is still a great challenge. In this work, through structural design, we fabricated a simple Ecoflex/Overlapping Graphene/Ecoflex (EOGE) strain sensor by encapsulating a graphene sensing element on polymer Ecoflex substrates using a drop-casting method. The EOGE strain sensor can detect stretching with high sensitivity, a maximum gauge factor of 715 with a wide strain range up to 57%, and adequate reliability and stability over 1,000 cycles for stretching. Moreover, the EOGE strain sensor shows recoverable structure deformation, and the sensor has a steady response in the frequency disturbance test. The good property of the strain sensor is attributed to the resistance variation induced by the overlap and crack structure of graphene by structural design. The vibrations caused by sound and various body movements have been thoroughly detected, which exhibited that the EOGE strain sensor is a promising candidate for wearable biomedical electronic applications.

Vocal Fold Vibration Characteristics during SOVTE using a Vibration Simulator and Digital Kymography

Objectives: The purpose of this study is to investigate the characteristics of vocal fold vibration during sustained vowel /a/ phonation and various semi-occluded vocal tract exercise (SOVTEs) using a vibration simulator and digital kymography (DKG).Methods: A total of 12 normal young speakers (6 males, 6 females) aged 20-30 years participated in the study. They phonated a sustained /a/ vowel and performed SOVTE. The vocal fold vibration characteristics were measured according to the number of vibration sources (single vs. double), and vocal tract occlusion degree using a vibration simulator and DKG. Glottal gap quotient (GQ, %), speed quotient (SQ, %) and amplitude (pixel) were estimated quantitatively from the DKG image.Results: The results showed that significantly higher GQ (p = .000) and SQ (p = .000) were observed in the humming and bilabial fricative /β/ compared to open vowels. The amplitude was significantly higher in the open vowel /a/ than in humming (p = .018) and bilabial fricative /β/ (p = .003). Also, when comparing the vocal fold vibration parameters according to vibration type (single source: straw phonation vs. double source: straw phonation with water), the double source presented a significantly higher GQ (p = .000) as well as SQ (p = .008) in comparison with a single source.Conclusion: SOVTE showed a glottal gap that is different from the opened vowel /a/. It also had a longer opening of the vocal fold and a smaller amplitude than the vowel. This suggests that SOVTE may be helpful for facilitating vocal fold vibration and good voice quality in clinical practice. The current study can be meaningful in providing theoretical and clinical evidence for SOVTE.

Role of stroboscopy in evaluation of patients with vocal abnormalities

<p class="abstract"><strong>Background:</strong> Stroboscopy is an examination in which strobe light is combined with laryngoscopy, to visualize the vocal fold vibration. It makes use of the Talbot’s law for visualizing the vibrating vocal fold having frequency of around 250 times per sec. This technique was used for studying voice abnormalities and evaluate related pathologies. The aim and objective was to evaluate patients with vocal abnormalities with the help of stroboscope and to study the mucosal wave pattern pre and post treatment of vocal cord pathologies.</p><p class="abstract"><strong>Methods:</strong> A prospective observational study was conducted at a tertiary care facility in central India. 50 patients with vocal abnormalities for more than 2 weeks were subjected to stroboscopy. Written informed consent from eligible patients was obtained and they were evaluated by stroboscopy using Karl Storz stroboscope with 70 degree 8 mm telescope, model no.: 20140020032. A second follow up stroboscopy was done two months post treatment and the parameters were recorded.</p><p class="abstract"><strong>Results:</strong> VC nodule was observed as the most common pathology followed by vocal polyp, carcinoma and chronic laryngitis. It was also observed that there was statistically significant difference (p&lt;0.001) in pre and post treatment findings of different parameters of voice evaluated using stroboscopy.</p><p class="abstract"><strong>Conclusions:</strong> Video stroboscopic evaluation proved to be a useful and reliable tool for evaluation and treatment of the patients with voice abnormalities as the changes in pre and post treatment voice parameters were found to be statistically significant.</p>

Monitoring of Physiological Sounds with Wearable Device based on Piezoelectric MEMS Acoustic Sensor

Physiological mechano-acoustic signals play a pivotal role in medical diagnosis and fitness monitoring. Mechanical waves generated by natural physiological activities such as myocardial contraction, and vocal fold vibration, propagate through the tissues and fluids of the body and reveal characteristic signals of these events. Conventional methods such as stethoscope and electrocardiography (ECG) are not suitable for wearable mode and continuous monitoring. In this paper, we propose a wearable physiological sounds sensing device to monitor heart sound and detect speech and voice with high accuracy. The device consists of a MEMS (microelectromechanical systems) acoustic sensor and a low-noise amplification circuit, and both of them are packaged by silicone polymers with an air cavity to achieve conformal contact with human skin. The proposed device has advantages of light weight, sweatproof capability, resistant to noise and good stability. The wearable device has great potential in clinical diagnosis, healthcare, human-machine interaction and many other applications.

Comparative analysis of high-speed videolaryngoscopy images and sound data simultaneously acquired from rigid and flexible laryngoscope: a pilot study

High-Speed Videoendoscopy (HSV) is becoming a robust tool for the assessment of vocal fold vibration in laboratory investigation and clinical practice. We describe the first successful application of flexible High Speed Videoendoscopy with innovative laser light source conducted in clinical settings. The acquired image and simultaneously recorded audio data are compared to the results obtained by means of a rigid endoscope. We demonstrated that the HSV recordings with fiber-optic laryngoscope have enabled obtaining consistently bright, color images suitable for parametrization of vocal fold oscillation similarly as in the case of the HSV data obtained from a rigid laryngoscope. The comparison of period and amplitude perturbation parameters calculated on the basis of image and audio data acquired from flexible and rigid HSV recording objectively confirm that flexible High-Speed Videoendoscopy is a more suitable method for examination of natural phonation. The HSV-based measures generated from this kymographic analysis are arguably a superior representation of the vocal fold vibrations than the acoustic analysis because their quantification is independent of the vocal tract influences. This experimental study has several implications for further research in the field of HSV application in clinical assessment of glottal pathologies nature and its effect on vocal folds vibrations.

Effects of Vertical Glottal Duct Length on Intraglottal Pressures in the Convergent Glottis

In a previous study, the vertical glottal duct length was examined for its influence on intraglottal pressures and other aerodynamic parameters in the uniform glottis [J Voice 32, 8–22 (2018)]. This study extends that work for convergent glottal angles, the shape of the glottis during the glottal opening phase of vocal fold vibration. The computational fluid dynamics code ANSYS Fluent 6.3 was used to obtain the pressure distributions and other aerodynamic parameters for laminar, incompressible, two-dimensional flow in a static vocal fold model. Four typical vertical glottal duct lengths (0.108, 0.308, 0.608, 0.908 cm) were selected for three minimal diameters (0.01, 0.04, 0.16 cm), three transglottal pressures (500, 1000, 1500 Pa), and three convergent glottal angles (−5°, −10°, −20°). The results suggest that a longer vertical glottal duct length increases the intraglottal pressures, decreases the glottal entrance loss coefficient, increases the transglottal pressure coefficient, causes a lower gradient of both the intraglottal flow velocity and the wall shear stress along the glottal wall—especially for low flows and small glottal minimal diameters—and has little effect on the exit pressure coefficient and volume flow. The vertical glottal duct length in the convergent glottis has important effects on phonation and should be well specified when building computational and physical models of the vocal folds.