Effects of Anabolic Precursors on Serum Testosterone Concentrations and Adaptations to Resistance Training in Young Men

2000 ◽  
Vol 10 (3) ◽  
pp. 340-359 ◽  
Author(s):  
Gregory A. Brown ◽  
Matthew D. Vukovich ◽  
Tracy A. Reifenrath ◽  
Nathaniel L. Uhl ◽  
Kerry A. Parsons ◽  
...  
Keyword(s):  
Resistance Training ◽  
Young Men ◽  
Serum Testosterone ◽  
Acute Effect ◽  
Total Testosterone ◽  
Tribulus Terrestris ◽  
Serum Estradiol ◽  
Herbal Extracts ◽  
Treatment Groups ◽  
Daily Dose

The effects of androgen precursors, combined with herbal extracts designed to enhance testosterone formation and reduce conversion of androgens to estrogens was studied in young men. Subjects performed 3 days of resistance training per week for 8 weeks. Each day during Weeks 1,2,4,5,7, and 8, subjects consumed either placebo (PL; n = 10) or a supplement (ANDRO-6; n = 10), which contained daily doses of 300 mg androstenedione, 150 mg DHEA, 750 mg Tribulus terrestris, 625 mg Chrysin, 300 mg Indole-3-carbinol, and 540 mg Saw palmetto. Serum androstenedione concentrations were higher in ANDRO-6 after 2,5, and 8 weeks (p < .05), while serum concentrations of free and total testosterone were unchanged in both groups. Serum estradiol was elevated at Weeks 2, 5, and 8 in ANDRO-6 (p < .05), and serum estrone was elevated at Weeks 5 and 8 (p < .05). Muscle strength increased (p < .05) similarly from Weeks 0 to 4, and again from Weeks 4 to 8 in both treatment groups. The acute effect of one third of the daily dose, of ANDRO-6 and PL was studied in 10 men (23±4years). Serum androstenedione concentrations were elevated (p < .05) in ANDRO-6 from 150 to 360 min after ingestion, while serum free or total testosterone concentrations were unchanged. These data provide evidence that the addition of these herbal extracts to androstenedione does not result in increased serum testosterone concentrations, reduce the estrogenic effect of androstenedione, and does not augment the adaptations to resistance training.

scholarly journals Effect of oral DHEA on serum testosterone and adaptations to resistance training in young men

1999 ◽  
Vol 87 (6) ◽  
pp. 2274-2283 ◽  
Author(s):  
Gregory A. Brown ◽  
Matthew D. Vukovich ◽  
Rick L. Sharp ◽  
Tracy A. Reifenrath ◽  
Kerry A. Parsons ◽  
...  
Keyword(s):  
Resistance Training ◽  
Young Men ◽  
Serum Testosterone ◽  
Treated Group ◽  
Whole Body ◽  
Total Testosterone ◽  
Resistance Training Program ◽  
Body Resistance ◽  
Liver Transaminases ◽  
And Training

This study examined the effects of acute dehydroepiandrosterone (DHEA) ingestion on serum steroid hormones and the effect of chronic DHEA intake on the adaptations to resistance training. In 10 young men (23 ± 4 yr old), ingestion of 50 mg of DHEA increased serum androstenedione concentrations 150% within 60 min ( P < 0.05) but did not affect serum testosterone and estrogen concentrations. An additional 19 men (23 ± 1 yr old) participated in an 8-wk whole body resistance-training program and ingested DHEA (150 mg/day, n = 9) or placebo ( n = 10) during weeks 1, 2, 4, 5, 7, and 8. Serum androstenedione concentrations were significantly ( P < 0.05) increased in the DHEA-treated group after 2 and 5 wk. Serum concentrations of free and total testosterone, estrone, estradiol, estriol, lipids, and liver transaminases were unaffected by supplementation and training, while strength and lean body mass increased significantly and similarly ( P < 0.05) in the men treated with placebo and DHEA. These results suggest that DHEA ingestion does not enhance serum testosterone concentrations or adaptations associated with resistance training in young men.

scholarly journals Acute hormonal response to sublingual androstenediol intake in young men

2002 ◽  
Vol 92 (1) ◽  
pp. 142-146 ◽  
Author(s):  
Gregory A. Brown ◽  
Emily R. Martini ◽  
B. Scott Roberts ◽  
Matthew D. Vukovich ◽  
Douglas S. King
Keyword(s):  
Peak Concentration ◽  
Young Men ◽  
Serum Testosterone ◽  
Free Testosterone ◽  
Total Testosterone ◽  
Serum Estradiol ◽  
Hormonal Response ◽  
Double Blind ◽  
First Pass ◽  
Serum Hormone

The effectiveness of orally ingested androstenediol in raising serum testosterone concentrations may be limited because of hepatic breakdown of the ingested androgens. Because androstenediol administered sublingually with cyclodextrin bypasses first-pass hepatic catabolism, we evaluated the acute hormonal response to sublingual cyclodextrin androstenediol supplement in young men. Eight men (22.9 ± 1.2 yr) experienced in strength training consumed either 20 mg androstenediol in a sublingual cyclodextrin tablet (Sl Diol) or placebo (Pl) separated by at least 1 wk in a randomized, double-blind, crossover manner. Blood samples were collected before supplementation and at 30-min intervals for 3 h after supplementation. Serum hormone concentrations did not change with Pl. Serum androstenedione concentrations were increased ( P < 0.05) above baseline (11.2 ± 1.1 nmol/l) with Sl Diol from 60 to 180 min after intake and reached a peak concentration of 25.2 ± 2.9 nmol/l at 120 min. Serum free testosterone concentrations were increased from 86.2 ± 9.1 pmol/l with Sl Diol from 30 to 180 min and reached a peak concentration of 175.4 ± 12.2 pmol/l at 60 min. Serum total testosterone concentrations increased above basal (25.6 ± 2.3 nmol/l) from 30 to 180 min with Sl Diol and reached a peak concentration of 47.9 + 2.9 nmol/l at 60 min. Serum estradiol concentrations were elevated ( P < 0.05) above baseline (0.08 ± 0.01 nmol/l) from 30 to 180 min with Sl Diol and reached 0.14 ± 0.02 nmol/l at 180 min. These data indicate that sublingual cyclodextrin androstenediol intake increases serum androstenedione, free testosterone, total testosterone, and estradiol concentrations.

Sexual Behaviour in Male Healthy Rats: A Comparison Between Indian Tribulus terrestris Linn. Extracts with Protodioscin Standardized Bulgarian Extract

2019 ◽  
Vol 9 (1) ◽  
pp. 32-38
Author(s):  
Mohammed Azeemuddin Mukhram ◽  
Mohamed Rafiq ◽  
Neeraj Kumar ◽  
Atul Namdeorao Jadhav ◽  
Suryakanth Dattatray Anturlikar ◽  
...  
Keyword(s):  
Serum Testosterone ◽  
Male Rats ◽  
Tribulus Terrestris ◽  
Mean Values ◽  
Treatment Groups ◽  
Group I ◽  
Significant Difference ◽  
Respective Treatment ◽  
Sex Stimulant ◽  
Ranking Analysis

Background: Tribulus terrestris Linn. (TT) is reported for its ability to improve male sexual performance, and protodioscin is responsible for the activity. This study was designed to correlate and compare various extracts of Indian TT with Bulgarian TT, and also the effect of protodioscin content on the activity. Methods: Bulgarian TT extract (BT) and prepared solvent extracts [aqueous (WIT), supercritical fluid (SIT) and methanol (MIT)] of Indian TT were standardized and compared using UV spectrophotometric method. Forty male rats were randomized into 5 groups of 8 each. Group I served as untreated control and group II to V were treated with 100 mg/Kg b.wt. of MIT, WIT, BT and SIT, respectively. The groups received the respective treatment for fourteen days. Sexual behavior of the rats was observed on Day-1&14. Serum testosterone was estimated after the last observation. Results: It was found that there was a statistically significant difference between the treatment groups. However, based on the mean values/ranking analysis of all the parameters, the order of potency was WIT > SIT &#8805; BT > MIT. Conclusion: These findings indicate that the aqueous extract of Indian TT which contains lesser protodioscin showed comparatively better sex stimulant activity in comparison to the other tested extracts.

Acute effect of stretching prior to resistance training on morphological, functional and activation indicators of skeletal muscle in young men

2021 ◽  
Author(s):  
Osvaldo Costa Moreira ◽  
Rusdael Mauro Bandeira Cardozo ◽  
Matheus de Almeida Vicente ◽  
Dihogo Gama de Matos ◽  
Mauro Lúcio Mazini Filho ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Resistance Training ◽  
Young Men ◽  
Acute Effect

scholarly journals Differences in the Apparent Metabolic Clearance Rate of Testosterone in Young and Older Men with Gonadotropin Suppression Receiving Graded Doses of Testosterone

2006 ◽  
Vol 91 (11) ◽  
pp. 4669-4675 ◽  
Author(s):  
Andrea D. Coviello ◽  
Kishore Lakshman ◽  
Norman A. Mazer ◽  
Shalender Bhasin
Keyword(s):  
Lean Body Mass ◽  
Body Mass ◽  
Young Men ◽  
Serum Testosterone ◽  
Older Men ◽  
Total Testosterone ◽  
Metabolic Clearance ◽  
Clearance Rates ◽  
Testosterone Levels ◽  
Age Related

Abstract Background: Recently we found that testosterone levels are higher in older men than young men receiving exogenous testosterone. We hypothesized that older men have lower apparent testosterone metabolic clearance rates (aMCR-T) that contribute to higher testosterone levels. Objective: The objective of the study was to compare aMCR-T in older and young men and identify predictors of aMCR-T. Methods: Sixty-one younger (19–35 yr) and 60 older (59–75 yr) men were given a monthly GnRH agonist and weekly testosterone enanthate (TE) (25, 50, 125, 300, or 600 mg) for 5 months. Estimated aMCR-T was calculated from the amount of TE delivered weekly and trough serum testosterone concentrations, corrected for real-time absorption kinetics from the im testosterone depot. Results: Older men had lower total (316 ± 13 vs. 585 ± 26 ng/dl, P &lt; 0.00001) and free testosterone (4 ± 0.1 vs. 6 ± 0.3 ng/dl, P &lt; 0.00001) and higher SHBG (52 ± 3 vs. 33 ± 2 nmol/liter, P &lt; 0.00001) than younger men at baseline. Total and free testosterones increased with TE dose and were higher in older men than young men in the 125-, 300-, and 600-mg dose groups. aMCR-T was lower in older men than young men (1390 ± 69 vs. 1821 ± 102 liter/d, P = 0.006). aMCR-T correlated negatively with age (P = 0.0007), SHBG (P = 0.046), and total testosterone during treatment (P = 0.02) and percent body fat at baseline (P = 0.01) and during treatment (P = 0.004). aMCR-T correlated positively with lean body mass at baseline (P = 0.03) and during treatment (P = 0.01). In multiple regression models, significant predictors of aMCR-T included lean body mass (P = 0.008), percent fat mass (P = 0.009), and SHBG (P = 0.001). Conclusions: Higher testosterone levels in older men receiving TE were associated with an age-related decrease in apparent testosterone metabolic clearance rates. Body composition and SHBG were significant predictors of aMCR-T.

scholarly journals Distinct and convergent beneficial effects of estrogen and insulin on cognitive function in healthy young men

2021 ◽  
Author(s):  
Rosemarie Krug ◽  
Laura Beier ◽  
Michael Lämmerhofer ◽  
Manfred Hallschmid
Keyword(s):  
Verbal Memory ◽  
Short Term Memory ◽  
Young Men ◽  
Young Male ◽  
Serum Testosterone ◽  
Fold Increase ◽  
Placebo Treatment ◽  
Acute Effect ◽  
Short Term ◽  
Combined Administration

Abstract Background Systematic investigations into the cognitive impact of estradiol and insulin in male individuals are sparse, and it is unclear whether the two hormones interact to benefit specific cognitive functions in humans. We investigated the acute effect of estradiol and insulin and of their combined administration on divergent (creative) and convergent (arithmetical) thinking as well as short-term and working verbal memory in healthy young men. Methods According to a 2×2 design, two groups of men (each n=16) received a 3-day transdermal estradiol (100 µg/24 h) or placebo pre-treatment and on two separate mornings were intranasally administered 160 IU regular human insulin and, respectively, placebo before completing a battery of cognitive tests; we also determined relevant blood parameters. Results Estrogen compared to placebo treatment induced a 3.5-fold increase in serum estradiol and suppressed serum testosterone concentrations by 70%. Estrogen in comparison to placebo improved creative performance, i.e., verbal fluency and flexibility, but not arithmetical thinking, as well as verbal short-term memory, but not visuospatial memory. The combination of estrogen and insulin enhanced recognition discriminability at delayed verbal memory recall; insulin alone remained without effect. Conclusions Estrogen specifically enhances core aspects of creativity and verbal memory in young male individuals; delayed recognition memory benefits from the combined administration of estradiol and insulin. Our results indicate that insulin’s acute cognitive impact in young men is limited and not robustly potentiated by estradiol. Estradiol per se exerts a beneficial acute effect on creative and verbal performance in healthy young men.

Effects of Androstenedione-Herbal Supplementation on Serum Sex Hormone Concentrations in 30- to 59-Year-old Men

2001 ◽  
Vol 71 (5) ◽  
pp. 293-301 ◽  
Author(s):  
Gregory A. Brown ◽  
Matthew D. Vukovich ◽  
Emily R. Martini ◽  
Marian L. Kohut ◽  
Warren D. Franke ◽  
...  
Keyword(s):  
Specific Antigen ◽  
Serum Testosterone ◽  
Free Testosterone ◽  
Nutritional Supplement ◽  
Total Testosterone ◽  
Tribulus Terrestris ◽  
Herbal Products ◽  
Serum Free ◽  
Supplementation Period ◽  
Old Men

The effectiveness of a nutritional supplement designed to enhance serum testosterone concentrations and prevent the formation of dihydrotestosterone and estrogens from the ingested androgens was investigated in healthy 30- to 59-year old men. Subjects were randomly assigned to consume DION (300 mg androstenedione, 150 mg dehydroepiandrosterone, 540 mg saw palmetto, 300 mg indole-3-carbinol, 625 mg chrysin, and 750 mg Tribulus terrestris per day; n = 28) or placebo (n = 27) for 28 days. Serum free testosterone, total testosterone, androstenedione, dihydrotestosterone, estradiol, prostate-specific antigen (PSA), and lipid concentrations were measured before and throughout the 4-week supplementation period. Serum concentrations of total testosterone and PSA were unchanged by supplementation. DION increased (p < 0.05) serum androstenedione (342%), free testosterone (38%), dihydrotestosterone (71%), and estradiol (103%) concentrations. Serum HDL-C concentrations were reduced by 5.0 mg/dL in DION (p < 0.05). Increases in serum free testosterone (r2 = 0.01), androstenedione (r2 = 0.01), dihydrotestosterone (r2 = 0.03), or estradiol (r2 = 0.07) concentrations in DION were not related to age. While the ingestion of androstenedione combined with herbal products increased serum free testosterone concentrations in older men, these herbal products did not prevent the conversion of ingested androstenedione to estradiol and dihydrotestosterone.

scholarly journals Effect of Oral Androstenedione on Serum Testosterone and Adaptations to Resistance Training in Young Men

JAMA ◽  
1999 ◽  
Vol 281 (21) ◽  
pp. 2020 ◽  
Author(s):  
Douglas S. King ◽  
Rick L. Sharp ◽  
Matthew D. Vukovich ◽  
Gregory A. Brown ◽  
Tracy A. Reifenrath ◽  
...  
Keyword(s):  
Resistance Training ◽  
Young Men ◽  
Serum Testosterone

One Session of Resistance Training May Increase Serum Testosterone and Triiodetironine in Young Men?

2006 ◽  
Vol 38 (Supplement) ◽  
pp. S285
Author(s):  
Douglas P. Marin ◽  
Aylton J. Figueira ◽  
Luiz G. Pinto
Keyword(s):  
Resistance Training ◽  
Young Men ◽  
Serum Testosterone

scholarly journals Hypothalamic Response to Kisspeptin-54 and Pituitary Response to Gonadotropin-Releasing Hormone Are Preserved in Healthy Older Men

2018 ◽  
Vol 106 (4) ◽  
pp. 401-410 ◽  
Author(s):  
Ali Abbara ◽  
Shakunthala Narayanaswamy ◽  
Chioma Izzi-Engbeaya ◽  
Alexander N. Comninos ◽  
Sophie A. Clarke ◽  
...  
Keyword(s):  
Late Onset ◽  
Follicle Stimulating Hormone ◽  
Young Men ◽  
Serum Testosterone ◽  
Older Men ◽  
Gonadotropin Releasing Hormone ◽  
Total Testosterone ◽  
Releasing Hormone ◽  
Serum Gonadotropin ◽  
Similar Body

Background: Male testosterone levels decline by 1% per year from the age of 40 years. Whilst a primary testicular deficit occurs, hypothalamic or pituitary dysregulation may also coexist. This study aimed to compare the hypothalamic response to kisspeptin-54 and the pituitary response to gonadotropin-releasing hormone (GnRH) of older men with those of young men. Methods: Following 1 h of baseline sampling, healthy older men (n = 5, mean age 59.3 ± 2.9 years) received a 3-h intravenous infusion of either vehicle, kisspeptin-54 0.1, 0.3, or 1.0 nmol/kg/h or GnRH 0.1 nmol/kg/h, on five different study days. Serum gonadotropins and total testosterone were measured every 10 min and compared to those of young men (n = 5/group) (mean age 28.9 ± 2.0 years) with a similar body mass index (24 kg/m2) who underwent the same protocol. Results: Kisspeptin-54 and GnRH significantly stimulated serum gonadotropin release in older men compared to vehicle (p < 0.001 for all groups). Gonadotropin response to kisspeptin-54 was at least preserved in older men when compared to young men. At the highest dose of kisspeptin-54 (1.0 nmol/kg/h), a significantly greater luteinising hormone (LH) (p = 0.003) response was observed in older men. The follicle-stimulating hormone (FSH) response to GnRH was increased in older men (p = 0.002), but the LH response was similar (p = 0.38). Serum testosterone rises following all doses of kisspeptin-54 (p ≤ 0.009) were reduced in older men. Conclusions: Our data suggest that healthy older men without late-onset hypo­gonadism (LOH) have preserved hypothalamic response to kisspeptin-54 and pituitary response to GnRH, but impaired testicular response. Further work is required to investigate the use of kisspeptin-54 to identify hypothalamic deficits in men with LOH.

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