BIOTRANSFORMATION OF A GABAA RECEPTOR PARTIAL AGONIST IN SPRAGUE-DAWLEY RATS AND CYNOMOLGUS MONKEYS: IDENTIFICATION OF TWO UNIQUE N-CARBAMOYL METABOLITES

2005 ◽  
Vol 33 (11) ◽  
pp. 1688-1699 ◽  
Author(s):  
Christopher L. Shaffer ◽  
Mithat Gunduz ◽  
Thomas N. O'Connell ◽  
R. Scott Obach ◽  
Shiyin Yee
Keyword(s):  
Gabaa Receptor ◽  
Partial Agonist ◽  
Sprague Dawley ◽  
Cynomolgus Monkeys ◽  
Sprague Dawley Rats

362 Hepatotoxicological differences with ET 743 between sprague dawley rats and cynomolgus monkeys

2003 ◽  
Vol 144 ◽  
pp. s98 ◽  
Author(s):  
J. Verbeeck ◽  
A. Vynckier ◽  
A. Looszova ◽  
K. Anciaux ◽  
N. Bode ◽  
...  
Keyword(s):  
Sprague Dawley ◽  
Cynomolgus Monkeys ◽  
Sprague Dawley Rats

Comparison of ultradian and circadian oscillations of carbon dioxide production by various endotherms

1995 ◽  
Vol 268 (1) ◽  
pp. R253-R265 ◽  
Author(s):  
M. Stupfel ◽  
V. Gourlet ◽  
A. Perramon ◽  
P. Merat ◽  
G. Putet ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Premature Infants ◽  
Guinea Pigs ◽  
Carbon Dioxide Emission ◽  
Continuous Light ◽  
Co2 Concentration ◽  
Carbon Dioxide Production ◽  
Sprague Dawley ◽  
Cynomolgus Monkeys ◽  
Sprague Dawley Rats

Carbon dioxide emission (VCO2) was computed every 20 min from continuous CO2 concentration recordings taken during 3-30 consecutive days, in strictly controlled environmental conditions, in 54 OF1 mice, 99 Japanese quail, 66 Sprague-Dawley rats, 50 Hartley guinea pigs, 7 chicks, for 7-15 days on 2 Cynomolgus monkeys, and for 24 h on 7 premature infants. This VCO2 shows circadian and ultradian oscillations that were analyzed for frequencies and amplitudes in light-dark 12-h alternation (LD 12:12), continuous light (LL), and continuous dark (DD). Circadians were not always identified or were often masked in LL or DD (mostly in guinea pigs, quail, and rats), while ultradians (tau > or = 40 min) were found in all species, at every time, and in all light regimens. Analysis of variance and chi 2 show significant (P < 0.001) interspecies differences for ultradian (1.07 < tau < 1.40 h) intervals and for circadian and ultradian VCO2 amplitudes. Relationships between ultradian and circadian VCO2 oscillations differ according to the species, ultradians appearing as an entity characteristic for each endotherm species.

Electroencephalography (EEG) in Sprague–Dawley rats and cynomolgus monkeys: Super-intervals to increase model sensitivity

2015 ◽  
Vol 75 ◽  
pp. 159
Author(s):  
Leanne Bassett ◽  
Mylene Pouliot ◽  
Eric Troncy ◽  
Samir Abtout ◽  
Alexis Ascah ◽  
...  
Keyword(s):  
Sprague Dawley ◽  
Model Sensitivity ◽  
Cynomolgus Monkeys ◽  
Sprague Dawley Rats
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