Gender Differences in the Endotoxin-Induced Inflammatory and Vascular Responses: Potential Role of Poly(ADP-ribose) Polymerase Activation

2005 ◽  
Vol 315 (2) ◽  
pp. 812-820 ◽  
Author(s):  
Jon G. Mabley ◽  
Eszter M. Horváth ◽  
Kanneganti G. K. Murthy ◽  
Zsuzsanna Zsengellér ◽  
Anne Vaslin ◽  
...  
2020 ◽  
Vol 34 ◽  
pp. 205873842092917
Author(s):  
Virginia Corazzi ◽  
Andrea Ciorba ◽  
Piotr Henryk Skarżyński ◽  
Magdalena B Skarżyńska ◽  
Chiara Bianchini ◽  
...  

In the last years, the attention to the role of gender in physiopathology and pharmacology of diseases in several medical disciplines is rising; however, the data on the relationship between gender and audio-vestibular disorders are still inconclusive and sometimes confusing. With this letter to the editor, we would like to review the role of gender in audio-vestibular disorders. Literature data show that anatomic variances of the inner ear do exist in men and women and that the different physiology and/or hormonal influence between genders could produce different clinical outcome of routine audiological and vestibular tests. Beyond the epidemiological gender-related differences, the clinical data suggest that the gender has a potential role as an etiopathogenetic factor in audio-vestibular disorders and it is probably responsible for the different clinical features observed between male and female subjects.


2003 ◽  
Vol 30 (2) ◽  
pp. 281-304 ◽  
Author(s):  
GIGLIANA MELZI ◽  
KENDALL A. KING

The present study examined gender and age patterns of diminutive use in conversations between 32 Spanish-speaking Peruvian mothers and their three- and five-year-old children. Results confirm previous findings concerning both parents' greater use of diminutives with younger children and children's early acquisition of this complex aspect of morphology. However, findings do not support previous studies on gender differences in parental use of diminutives with young children. Results also revealed that mothers' and children's imitations of their interlocutors' diminutized words promoted their interlocutors' overall diminutive use. This finding highlights the acute sensitivity of both speakers to each others' language and the potential role of imitation in older children's language development.


2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.


Author(s):  
Katherine Guérard ◽  
Sébastien Tremblay

In serial memory for spatial information, some studies showed that recall performance suffers when the distance between successive locations increases relatively to the size of the display in which they are presented (the path length effect; e.g., Parmentier et al., 2005) but not when distance is increased by enlarging the size of the display (e.g., Smyth & Scholey, 1994). In the present study, we examined the effect of varying the absolute and relative distance between to-be-remembered items on memory for spatial information. We manipulated path length using small (15″) and large (64″) screens within the same design. In two experiments, we showed that distance was disruptive mainly when it is varied relatively to a fixed reference frame, though increasing the size of the display also had a small deleterious effect on recall. The insertion of a retention interval did not influence these effects, suggesting that rehearsal plays a minor role in mediating the effects of distance on serial spatial memory. We discuss the potential role of perceptual organization in light of the pattern of results.


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