MOLECULAR INTERVENTIONS Volume 2: This Time It's Personal

2002 ◽  
Vol 2 (2) ◽  
pp. 71-71
Author(s):  
H. Smith
Keyword(s):  
Molecular Interventions

scholarly journals Molecular Interventions towards Multiple Sclerosis Treatment

2020 ◽  
Vol 10 (5) ◽  
pp. 299
Author(s):  
Athanasios Metaxakis ◽  
Dionysia Petratou ◽  
Nektarios Tavernarakis
Keyword(s):  
Multiple Sclerosis ◽  
Autoimmune Response ◽  
Th2 Cells ◽  
Autoimmune Encephalomyelitis ◽  
T Helper 2 ◽  
Cellular Factors ◽  
Life Threatening ◽  
The Central Nervous System ◽  
Multiple Sclerosis Treatment ◽  
Molecular Interventions

Multiple sclerosis (MS) is an autoimmune life-threatening disease, afflicting millions of people worldwide. Although the disease is non-curable, considerable therapeutic advances have been achieved through molecular immunotherapeutic approaches, such as peptides vaccination, administration of monoclonal antibodies, and immunogenic copolymers. The main aims of these therapeutic strategies are to shift the MS-related autoimmune response towards a non-inflammatory T helper 2 (Th2) cells response, inactivate or ameliorate cytotoxic autoreactive T cells, induce secretion of anti-inflammatory cytokines, and inhibit recruitment of autoreactive lymphocytes to the central nervous system (CNS). These approaches can efficiently treat autoimmune encephalomyelitis (EAE), an essential system to study MS in animals, but they can only partially inhibit disease progress in humans. Nevertheless, modern immunotherapeutic techniques remain the most promising tools for the development of safe MS treatments, specifically targeting the cellular factors that trigger the initiation of the disease.

International Symposium on Endocrine and Molecular Interventions in Aging

1998 ◽  
Vol 1 (2) ◽  
pp. 143-144
Author(s):  
Barry B. Bercu ◽  
Richard F. Walker
Keyword(s):  
International Symposium ◽  
Molecular Interventions

Molecular Interventions (2001-2011): An Experiment Completed

2011 ◽  
Vol 11 (2) ◽  
pp. 62-62
Author(s):  
J. S. Lazo
Keyword(s):  
Molecular Interventions

Pharmacology Goes Phlat: Molecular Interventions Feels the Impact

2007 ◽  
Vol 7 (4) ◽  
pp. 178-178
Author(s):  
J. S. Lazo
Keyword(s):  
The Impact ◽  
Molecular Interventions

Tuberculosis: An Update on Pathophysiology, Molecular Mechanisms of Drug Resistance, Newer Anti-TB Drugs, Treatment Regimens and Host-Di-rected Therapies

2020 ◽  
Vol 21 ◽  
Author(s):  
Pobitra Borah ◽  
Pran Kishore Deb ◽  
Katharigatta N. Venugopala ◽  
Nizar A. Al-Shar’i ◽  
Vinayak Singh ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Molecular Mechanisms ◽  
Resistance Mechanisms ◽  
Cellular Functions ◽  
Pathogenic Potential ◽  
Treatment Regimens ◽  
Latent Tb ◽  
Clinical Advances ◽  
Anti Hiv ◽  
Molecular Interventions

Abstract: The human tuberculosis (TB) is primarily caused by Mycobacterium tuberculosis (Mtb) that inhabits inside and amidst immune cells of the host with adapted physiology to regulate interdependent cellular functions with intact pathogenic potential. The complexity of this disease is attributed to various factors such as the reactivation of latent TB form after prolonged persistence, disease progression specifically in immunocompromised patients, advent of multi- and extensively-drug resistant (MDR and XDR) Mtb strains, adverse effects of tailor-made regimens, and drug-drug interactions among anti-TB drugs and anti-HIV therapies. Thus there is a compelling demand for newer anti-TB drugs or regimens to overcome these obstacles. Considerable multifaceted transformations in the current TB methodologies and molecular interventions underpinning host-pathogen interactions and drug resistance mechanisms may assist to overcome the emerging drug re-sistance. Evidently, recent scientific and clinical advances have revolutionised the diagnosis, prevention and treatment of all forms of the disease. This review sheds light on the current understanding of the pathogenesis of TB disease, molecular mechanisms of drug-resistance, progress on the development of novel or repurposed anti-TB drugs and regimens, host-directed therapies, with particular emphasis on underlying knowledge gaps and prospective for futuristic TB control pro-grams.

A comprehensive review of adaptations in plants under arsenic toxicity: Physiological, metabolic and molecular interventions

2021 ◽  
pp. 118029
Author(s):  
Aarifa Nabi ◽  
M. Naeem ◽  
Tariq Aftab ◽  
M. Masroor A. Khan ◽  
Parvaiz Ahmad
Keyword(s):  
Arsenic Toxicity ◽  
Comprehensive Review ◽  
Molecular Interventions
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