Ginsenoside Re, a Main Phytosterol of Panax ginseng, Activates Cardiac Potassium Channels via a Nongenomic Pathway of Sex Hormones

2006 ◽  
Vol 70 (6) ◽  
pp. 1916-1924 ◽  
Author(s):  
Tetsushi Furukawa ◽  
Chang-Xi Bai ◽  
Asami Kaihara ◽  
Eri Ozaki ◽  
Takashi Kawano ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Panax Ginseng ◽  
Sex Hormones ◽  
Ginsenoside Re ◽  
Nongenomic Pathway

scholarly journals Ginsenoside Re Attenuates Isoproterenol-Induced Myocardial Injury in Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Quan-wei Wang ◽  
Xiao-feng Yu ◽  
Hua-li Xu ◽  
Yi-chuan Jiang ◽  
Xue-zhong Zhao ◽  
...  
Keyword(s):  
Panax Ginseng ◽  
Myocardial Injury ◽  
Troponin T ◽  
Histopathological Examination ◽  
Inflammatory Cells ◽  
Related Factor ◽  
Ginsenoside Re ◽  
Creatine Kinase Mb ◽  
Male Wistar Rats ◽  
Mda Content

Objective. Panax ginseng is widely used for treatment of cardiovascular disorders in China. Ginsenoside Re is the main chemical component of Panax ginseng. This study aimed to investigate the protective effect of Ginsenoside Re on isoproterenol-induced myocardial injury in rats. Methods. Male Wistar rats were orally given Ginsenoside Re (5, 20 mg/kg) daily for 7 days. Isoproterenol was subcutaneously injected into the rats for two consecutive days at a dosage of 20 mg/kg/day (on 6th and 7th day). Six hours after the last isoproterenol injection, troponin T level and creatine kinase-MB (CK-MB) activity were assayed. Histopathological examination of heart tissues was performed. The levels of malondialdehyde (MDA) and glutathione (GSH) in heart tissues were measured. The nuclear factor erythroid 2-related factor 2 (Nrf2) content in nucleus and the proteins of glutathione cysteine ligase catalytic subunit (GCLC) and glutathione cysteine ligase modulatory subunit (GCLM) in heart tissues were assayed by western blotting method. Results. Treatment with Ginsenoside Re at dose of 5, 20 mg/kg reduced troponin T level and CK-MB activity of rats subjected to isoproterenol. The cardioprotective effect of Ginsenoside Re was further confirmed by histopathological examination which showed that Ginsenoside Re attenuated the necrosis and inflammatory cells infiltration. Ginsenoside Re inhibited the increase of MDA content and the decrease of GSH in heart tissues. Moreover, the Nrf2 content in nucleus and the expressions of GCLC and GCLM were significantly increased in the animals treated with Ginsenoside Re. Conclusion. These findings suggested that Ginsenoside Re possesses the property to attenuate isoproterenol-induced myocardial ischemic injury by regulating the antioxidation function in cardiomyocytes.

scholarly journals Ginsenoside Prolongs the Lifespan of C. elegans via Lipid Metabolism and Activating the Stress Response Signaling Pathway

2021 ◽  
Vol 22 (18) ◽  
pp. 9668
Author(s):  
Xiaoxuan Yu ◽  
Hui Li ◽  
Dongfa Lin ◽  
Weizhuo Guo ◽  
Zhihao Xu ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Panax Ginseng ◽  
Underlying Mechanism ◽  
Rna Seq ◽  
Ginsenoside Re ◽  
Ginsenoside Rd ◽  
C Elegans ◽  
Kegg Pathway Analysis ◽  
And Oxidative Stress ◽  
Insight Into

Panax ginseng is a valuable traditional Chinese medicine in Northeast China. Ginsenoside, the active component of ginseng, has not been investigated much for its effects on aging and its underlying mechanism(s) of action. Here, we investigated the effects of total ginsenoside (TG), a mixture of the primary active ginsenosides from Panax ginseng, on the lifespan of Caenorhabditis elegans (C. elegans). We found that TG extended the lifespan of C. elegans and reduced lipofuscin accumulation. Moreover, TG increased the survival of C. elegans in response to heat and oxidative stress via the reduction of ROS. Next, we used RNA-seq to fully define the antiaging mechanism(s) of TG. The KEGG pathway analysis showed that TG can prolong the lifespan and is involved in the longevity regulating pathway. qPCR showed that TG upregulated the expression of nrh-80, daf-12, daf-16, hsf-1 and their downstream genes. TG also reduced the fat accumulation and promoted lipid metabolism. Moreover, TG failed to extend the lifespan of daf-16 and hsf-1 mutants, highlighting their role in the antiaging effects of TG in C. elegans. The four main constitution of TG were then confirmed by HPLC and included ginsenoside Re, Rg1, Rg2 and Rd. Of the ginsenosides, only ginsenoside Rd prolonged the lifespan of C. elegans to levels comparable to TG. These findings provided mechanistic insight into the antiaging effects of ginsenoside in C. elegans.

A Natural Compound (Ginsenoside Re) Isolated from Panax ginseng as a Novel Angiogenic Agent for Tissue Regeneration

2005 ◽  
Vol 22 (4) ◽  
pp. 636-646 ◽  
Author(s):  
Ya-Chun Huang ◽  
Chiung-Tong Chen ◽  
Sung-Ching Chen ◽  
Po-Hong Lai ◽  
Huang-Chien Liang ◽  
...  
Keyword(s):  
Panax Ginseng ◽  
Tissue Regeneration ◽  
Natural Compound ◽  
Ginsenoside Re

scholarly journals NOVEL APPLICATION OF CULTURED ROOTS OF MOUNTAIN GINSENG (PANAX GINSENG MEYER) AND GINSENOSIDE RE AS SAFE ANTIMELANOGENIC COSMECEUTICAL COMPONENTS

2017 ◽  
Vol 14 (5) ◽  
pp. 209-218 ◽  
Author(s):  
Zuly Elizabeth Jimenez-Perez ◽  
Yeaon-ju Kim ◽  
Veronica Castro-Aceituno ◽  
Ranya Mathiyalagan ◽  
Josua Markus ◽  
...  
Keyword(s):  
Panax Ginseng ◽  
Ginsenoside Re

Ginsenoside Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats

2006 ◽  
Vol 550 (1-3) ◽  
pp. 173-179 ◽  
Author(s):  
William C.S. Cho ◽  
Wai-Shing Chung ◽  
Sally K.W. Lee ◽  
Albert W.N. Leung ◽  
Christopher H.K. Cheng ◽  
...  
Keyword(s):  
Panax Ginseng ◽  
Diabetic Rats ◽  
Ginsenoside Re

scholarly journals Comparative Analysis of Panax ginseng Berries from Seven Cultivars Using UPLC-QTOF/MS and NMR-Based Metabolic Profiling

Biomolecules ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 424 ◽  
Author(s):  
Yoon ◽  
Choi ◽  
Kim ◽  
Oh ◽  
Kim ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Panax Ginseng ◽  
Ultra Performance Liquid Chromatography ◽  
Magic Angle Spinning ◽  
The Other ◽  
Magic Angle ◽  
Ginsenoside Re ◽  
Primary Metabolites ◽  
Primary And Secondary Metabolites ◽  
Commercial Use

The commercial use of Panax ginseng berries is increasing as P. ginseng berries are known to contain large amounts of ginsenosides, and many pharmacological activities have been reported for the various ginsenosides. For the proper use of P. ginseng berries, it is necessary to study efficient and accurate quality control and the profiling of the overall composition of each cultivar. Ginseng berry samples from seven cultivars (Eumseung, Chung-buk Province, Republic of Korea) were analyzed using ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UPLC-QTOF/MS) for profiling of the ginsenosides, and high-resolution magic-angle-spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy for profiling of the primary metabolites. Comparing twenty-six ginsenoside profiles between the variant representatives and between the violet-stem variant, Kumpoong and Sunwon were classified. In the case of primary metabolites, the cultivars Kumpoong and Gopoong were classified. As a result of correlation analyses of the primary and secondary metabolites, in the Gopoong cultivar, the metabolism was found to lean toward energy metabolism rather than ginsenoside synthesis, and accumulation of osmolytes was low. The Gopoong cultivar had higher levels of most of the amino acids, such as arginine, phenylalanine, isoleucine, threonine, and valine, and it contained the highest level of choline and the lowest level of myo-inositol. Except for these, there were no significant differences of primary metabolites. In the Kumpoong cultivar, the protopanaxatriol (PPT)-type ginsenosides, ginsenoside Re and ginsenoside Rg2, were much lower than in the other cultivars, while the other PPT-type ginsenosides were inversely found in much higher amounts than in other cultivars. The Sunwon cultivar showed that variations of PPT-type ginsenosides were significantly different between samples. However, the median values of PPT-type ginsenosides of Sunwon showed similar levels to those of Kumpoong. The difference in primary metabolites used for metabolism for survival was found to be small in our results. Our data demonstrated the characteristics of each cultivar using profiling data of the primary and secondary metabolites, especially for Gopoong, Kumpoong, and Sunwon. These profiling data provided important information for further research and commercial use.

scholarly journals Ginsenoside Content of Berries and Roots of Three Typical Korean Ginseng (Panax Ginseng) Cultivars

2009 ◽  
Vol 4 (7) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Yong Kyoung Kim ◽  
Dae Seok Yoo ◽  
Hui Xu ◽  
Nam Il Park ◽  
Hyun Ho Kim ◽  
...  
Keyword(s):  
Panax Ginseng ◽  
Ginsenoside Re ◽  
Ginsenoside Content ◽  
Korean Ginseng

The ginsenoside content of berries and roots of three cultivars of Korean ginseng have been investigated. For all cultivars, ginsenoside Re was the most abundant ginsenoside in roots and berries. However, berries produced more total ginsenosides, and berry the ginsenoside profile differed from that of roots. The ginsenoside Re content of berries was 4-6 times more than that of roots. Averaged across all cultivars, the amounts of the five ginsenosides in berries was Re > Rc ≈ Rg1 ≈ Rb1 ≈ Rd. For roots, the amounts were Re > Rg1 > Rb1 > Rc >Rd. Roots of the Yunpoong cultivar had the greatest ginsenoside content, followed by roots of the Chunpoong cultivar and the Gumpoong cultivar. The total amount of ginsenosides (especially Rb1, Re, and Rg1) was greatest in the Yunpoong cultivar.

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