scholarly journals Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention

2020 ◽  
Vol 6 (34) ◽  
pp. eabb5353
Author(s):  
Anders E. Hansen ◽  
Jonas R. Henriksen ◽  
Rasmus I. Jølck ◽  
Frederikke P. Fliedner ◽  
Linda M. Bruun ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Diagnostic Imaging ◽  
Therapeutic Intervention ◽  
Near Infrared ◽  
Image Features ◽  
Therapeutic Interventions ◽  
Marker System ◽  
Image Guided Radiotherapy ◽  
Surgical Interventions ◽  
Tissue Marker

Diagnostic imaging often outperforms the surgeon’s ability to identify small structures during therapeutic procedures. Smart soft tissue markers that translate the sensitivity of diagnostic imaging into optimal therapeutic intervention are therefore highly warranted. This paper presents a unique adaptable liquid soft tissue marker system based on functionalized carbohydrates (Carbo-gel). The liquid state of these markers allows for high-precision placement under image guidance using thin needles. Based on step-by-step modifications, the image features and mechanical properties of markers can be optimized to bridge diagnostic imaging and specific therapeutic interventions. The performance of Carbo-gel is demonstrated for markers that (i) have radiographic, magnetic resonance, and ultrasound visibility; (ii) are palpable and visible; and (iii) are localizable by near-infrared fluorescence and radio guidance. The study demonstrates encouraging proof of concept for the liquid marker system as a well-tolerated multimodal imaging marker that can improve image-guided radiotherapy and surgical interventions, including robotic surgery.

Recent Nano-based Therapeutic Intervention of Bioactive Sesquiterpenes: Prospects in Cancer Therapeutics

2020 ◽  
Vol 26 (11) ◽  
pp. 1138-1144 ◽  
Author(s):  
Mohammad A. Ansari ◽  
Khan F. Badrealam ◽  
Asrar Alam ◽  
Saba Tufail ◽  
Gulshan Khalique ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Essential Oils ◽  
Plant Species ◽  
Bioactive Compounds ◽  
Therapeutic Intervention ◽  
Cancer Therapeutics ◽  
Therapeutic Interventions ◽  
Pharmacological Intervention ◽  
Clinical Applicability ◽  
Near Future

: In the recent scenario, nanotechnology-based therapeutics intervention has gained tremendous impetus all across the globe. Nano-based pharmacological intervention of various bioactive compounds has been explored on an increasing scale. Sesquiterpenes are major constituents of essential oils (EOs) present in various plant species which possess intriguing therapeutic potentials. However, owing to their poor physicochemical properties; they have pharmacological limitations. Recent advances in nano-based therapeutic interventions offer various avenues to improve their therapeutic applicability. Reckoning with these, the present review collates various nano-based therapeutic intervention of sesquiterpenes with prospective potential against various debilitating diseases especially cancer. In our viewpoint, considering the burgeoning advancement in the field of nanomedicine; in the near future, the clinical applicability of these nano-formulated sesquiterpenes can be foreseen with great enthusiasm.

scholarly journals Diagnostic Imaging and Management of Common Intra-articular and Peri-articular Soft Tissue Tumors and Tumorlike Conditions of the Knee

2018 ◽  
Vol 32 (04) ◽  
pp. 322-330 ◽  
Author(s):  
Andrea Evenski ◽  
James Stensby ◽  
Samuel Rosas ◽  
Cynthia Emory
Keyword(s):  
Soft Tissue ◽  
Diagnostic Imaging ◽  
Synovial Sarcoma ◽  
Synovial Chondromatosis ◽  
Soft Tissue Tumors ◽  
Pigmented Villonodular Synovitis ◽  
Villonodular Synovitis ◽  
Timely Manner ◽  
Malignant Lesions ◽  
Pigmented Villonodular

AbstractIntra-articular (IA) and peri-articular (PA) tumors of the knee are frequently encountered by orthopaedic surgeons. Nonetheless, due to the possibility of great morbidity and potential mortality, it is important to recognize and differentiate between benign and malignant lesions in a timely manner. Therefore, the purpose of this article is to provide a concise, practical, and updated review of commonly encountered IA and PA tumors including intratendinous gout, synovial chondromatosis, schwannoma, pigmented villonodular synovitis, and synovial sarcoma, and a detailed description of differentiating features to include various imaging modalities.

scholarly journals Application of a Novel Near Infrared-Fluorescence Giant Vesicle- and Polymerasome-based Tissue Marker for Endoscopic and Laparoscopic Navigation

2014 ◽  
Vol 30 (2) ◽  
pp. 225-230 ◽  
Author(s):  
Hirosuke HATAYAMA ◽  
Taro TOYOTA ◽  
Hideki HAYASHI ◽  
Tomonori NOMOTO ◽  
Masanori FUJINAMI
Keyword(s):  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Giant Vesicle ◽  
Tissue Marker

scholarly journals Evidence mapping based on systematic reviews of therapeutic interventions for soft tissue sarcomas

2019 ◽  
Vol 21 (10) ◽  
pp. 1398-1412 ◽  
Author(s):  
M. Ballesteros ◽  
N. Montero ◽  
A. López-Pousa ◽  
G. Urrútia ◽  
I. Solà ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Systematic Reviews ◽  
Soft Tissue Sarcomas ◽  
Therapeutic Interventions ◽  
Evidence Mapping

Image guided radiotherapy: Current status of soft tissue imaging

Radiography ◽  
2014 ◽  
Vol 20 (2) ◽  
pp. 158-161 ◽  
Author(s):  
Helen A. McNair ◽  
Mark Elsworthy ◽  
June Dean ◽  
Charlotte Beardmore
Keyword(s):  
Soft Tissue ◽  
Tissue Imaging ◽  
Current Status ◽  
Image Guided Radiotherapy ◽  
Image Guided

scholarly journals The Numbers Needed to Treat for Neurological Disorders

2005 ◽  
Vol 32 (4) ◽  
pp. 440-449 ◽  
Author(s):  
Miguel Bussière ◽  
Samuel Wiebe
Keyword(s):  
Absolute Risk ◽  
Time Frame ◽  
Therapeutic Interventions ◽  
Cochrane Library ◽  
Number Needed To Treat ◽  
Therapeutic Effects ◽  
Surgical Interventions ◽  
Blood Patch ◽  
Numbers Needed To Treat ◽  
Meta Analyses

ABSTRACT:Background:Numerous therapeutic interventions have been developed in the neurosciences. Clinicians need summary measures about efficacy of therapies that derive from the best available evidence, and that can be readily extrapolated to clinical practice. The number needed to treat (NNT) is intuitive and clinically applicable. We provide clinicians with a single source that summarizes important therapies in the main neurological and neurosurgical areas.Methods:Critically appraised evidence about therapies in the neurosciences was obtained from meta-analyses in all neurosciences groups in the Cochrane library, and from critically appraised topics at the University of Western Ontario. Therapies were included if they were deemed relevant and if outcomes were dichotomous. For each therapy, we obtained absolute risk differences and their 95% confidence intervals (CI), the corresponding NNTs, control and experimental event rates, and the time-frame of the outcome assessment.Results:We assembled a table of NNTs for 87 interventions in ten disease categories, deriving from meta-analyses (70%) or randomized controlled trials (30%), and assessing surgical interventions (7%), procedures (9%) or pharmacological treatments (84%). The NNTs varied widely, ranging from 1 in the use of epidural blood patch for post-dural puncture headache to 4608 for meningococcal vaccination. Preventative interventions had substantially larger NNTs. Time-frames were inappropriately short for many chronic conditions.Conclusions:Large collections of NNTs provide useful, updateable summaries of therapeutic effects in the neurosciences, an increasingly interventional clinical field.

Cerebral Blood Flow of the Neonatal Brain after Hypoxic-Ischemic Injury

2021 ◽  
Author(s):  
Luis Octavio Tierradentro-García ◽  
Sandra Saade-Lemus ◽  
Colbey Freeman ◽  
Matthew Kirschen ◽  
Hao Huang ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Near Infrared ◽  
Imaging Modality ◽  
Brain Perfusion ◽  
Correlation Spectroscopy ◽  
Therapeutic Interventions ◽  
Routine Practice ◽  
Diffuse Correlation Spectroscopy ◽  
Positron Emission

Objective Hypoxic-ischemic encephalopathy (HIE) in infants can have long-term adverse neurodevelopmental effects and markedly reduce quality of life. Both the initial hypoperfusion and the subsequent rapid reperfusion can cause deleterious effects in brain tissue. Cerebral blood flow (CBF) assessment in newborns with HIE can help detect abnormalities in brain perfusion to guide therapy and prognosticate patient outcomes. Study Design The review will provide an overview of the pathophysiological implications of CBF derangements in neonatal HIE, current and emerging techniques for CBF quantification, and the potential to utilize CBF as a physiologic target in managing neonates with acute HIE. Conclusion The alterations of CBF in infants during hypoxia-ischemia have been studied by using different neuroimaging techniques, including nitrous oxide and xenon clearance, transcranial Doppler ultrasonography, contrast-enhanced ultrasound, arterial spin labeling MRI, 18F-FDG positron emission tomography, near-infrared spectroscopy (NIRS), functional NIRS, and diffuse correlation spectroscopy. Consensus is lacking regarding the clinical significance of CBF estimations detected by these different modalities. Heterogeneity in the imaging modality used, regional versus global estimations of CBF, time for the scan, and variables impacting brain perfusion and cohort clinical characteristics should be considered when translating the findings described in the literature to routine practice and implementation of therapeutic interventions. Key Points

Sign in / Sign up

Export Citation Format

Share Document