Roles of Mast Cells and Basophils in Innate Immunity

Author(s):  
Stephen J. Galli ◽  
Devavani Chatterjea ◽  
Mindy Tsai
Keyword(s):  
2000 ◽  
Vol 173 (1) ◽  
pp. 131-140 ◽  
Author(s):  
Yoseph A. Mekori ◽  
Dean D. Metcalfe
Keyword(s):  

1998 ◽  
Vol 10 (5) ◽  
pp. 373-381 ◽  
Author(s):  
Soman N. Abraham ◽  
Michel Arock
Keyword(s):  

2013 ◽  
Vol 190 (9) ◽  
pp. 4458-4463 ◽  
Author(s):  
Ashley L. St. John ◽  
Soman N. Abraham
Keyword(s):  

2019 ◽  
Author(s):  
Camila Audrey dos Reis ◽  
José Rosa Gomes

ABSTRACTMMP-2 and MMP-9 are proteins with well stablished roles on the remodeling of tissue during morphogenesis. This study aimed to evaluate the activity and expression of the MMP-2 and MMP-9 in the rat small intestine mucosa layer on 15th and 18th days of intratuterine life (i.u.) and at 3rd, 10th, 17th, 25th, and 32th days after birth (a.b.). Samples were submitted to zimography, immunohistochemistry methods and Masson trichrome staining. Results showed that MMP-2 and MMP-9 were not expressed in the small intestine epithelium during intrauterine life. MMP-9 was immunolocalized in the villi goblet cells and in the lamina propria in cells identified as being the mast cells (a.b.). We concluded that in the i.u. and a.b. life the MMP-2 and MMP-9 were not expressed in the small intestine epithelium. However, after birth, because MMP-9 was expressed in the mast cels present in the lamina propria it may be involved in the remodeling process of the innate immunity that occurs during the small intestine development.


Cells ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 2411 ◽  
Author(s):  
Zyanya P. Espinosa-Riquer ◽  
Deisy Segura-Villalobos ◽  
Itzel G. Ramírez-Moreno ◽  
Marian Jesabel Pérez Rodríguez ◽  
Mónica Lamas ◽  
...  

Mast cells (MCs) constitute an essential cell lineage that participates in innate and adaptive immune responses and whose phenotype and function are influenced by tissue-specific conditions. Their mechanisms of activation in type I hypersensitivity reactions have been the subject of multiple studies, but the signaling pathways behind their activation by innate immunity stimuli are not so well described. Here, we review the recent evidence regarding the main molecular elements and signaling pathways connecting the innate immune receptors and hypoxic microenvironment to cytokine synthesis and the secretion of soluble or exosome-contained mediators in this cell type. When known, the positive and negative control mechanisms of those pathways are presented, together with their possible implications for the understanding of mast cell-driven chronic inflammation. Finally, we discuss the relevance of the knowledge about signaling in this cell type in the recognition of MCs as central elements on innate immunity, whose remarkable plasticity converts them in sensors of micro-environmental discontinuities and controllers of tissue homeostasis.


2004 ◽  
Vol 114 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Jean S Marshall ◽  
Dunia M Jawdat
Keyword(s):  

2003 ◽  
pp. 361-386
Author(s):  
Joshua A. Boyce ◽  
K. Frank Austen
Keyword(s):  

2017 ◽  
Vol 65 (5) ◽  
pp. 982-986 ◽  
Author(s):  
Pio Conti ◽  
Francesco Carinci ◽  
Gianfranco Lessiani ◽  
Enrico Spinas ◽  
Spyridon K. Kritas ◽  
...  

2019 ◽  
Vol 20 (8) ◽  
pp. 2040 ◽  
Author(s):  
Felice Rivellese ◽  
Francesca Wanda Rossi ◽  
Maria Rosaria Galdiero ◽  
Costantino Pitzalis ◽  
Amato de Paulis

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by inflammation of the synovial membrane, with thickening of the synovial layer, cellular hyperplasia, and infiltration of immune cells. Mast cells (MCs) are cells of the innate immunity present in healthy synovia and part of the cellular hyperplasia characterizing RA synovitis. Although their presence in synovia has been well described, the exact functions and the correlation of MCs with disease development and progression have been debated, particularly because of contradictory data obtained in animal models and from patients with longstanding disease. Here, we present a revision of the literature on MCs in RA, including the most recent observations obtained from patients with early RA, indicating MCs as relevant markers of disease severity in early RA.


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