Roles of Mast Cells and Basophils in Innate Immunity

2014 ◽  
pp. 111-132 ◽  
Author(s):  
Stephen J. Galli ◽  
Devavani Chatterjea ◽  
Mindy Tsai
Keyword(s):  
Innate Immunity ◽  
Mast Cells

Mast cells in innate immunity

2000 ◽  
Vol 173 (1) ◽  
pp. 131-140 ◽  
Author(s):  
Yoseph A. Mekori ◽  
Dean D. Metcalfe
Keyword(s):  
Innate Immunity ◽  
Mast Cells

Mast cells and basophils in innate immunity

1998 ◽  
Vol 10 (5) ◽  
pp. 373-381 ◽  
Author(s):  
Soman N. Abraham ◽  
Michel Arock
Keyword(s):  
Innate Immunity ◽  
Mast Cells

scholarly journals Innate Immunity and Its Regulation by Mast Cells

2013 ◽  
Vol 190 (9) ◽  
pp. 4458-4463 ◽  
Author(s):  
Ashley L. St. John ◽  
Soman N. Abraham
Keyword(s):  
Innate Immunity ◽  
Mast Cells

scholarly journals Are the Matrix Metalloproteinases 2 and 9 beeing expressed in the mucosa of the rat small intestine during its intrauterine and postnatal life development ?

2019 ◽  
Author(s):  
Camila Audrey dos Reis ◽  
José Rosa Gomes
Keyword(s):  
Innate Immunity ◽  
Small Intestine ◽  
Mast Cells ◽  
Lamina Propria ◽  
Goblet Cells ◽  
Postnatal Life ◽  
Rat Small Intestine ◽  
The Matrix ◽  
Intestine Mucosa ◽  
Masson Trichrome Staining

ABSTRACTMMP-2 and MMP-9 are proteins with well stablished roles on the remodeling of tissue during morphogenesis. This study aimed to evaluate the activity and expression of the MMP-2 and MMP-9 in the rat small intestine mucosa layer on 15th and 18th days of intratuterine life (i.u.) and at 3rd, 10th, 17th, 25th, and 32th days after birth (a.b.). Samples were submitted to zimography, immunohistochemistry methods and Masson trichrome staining. Results showed that MMP-2 and MMP-9 were not expressed in the small intestine epithelium during intrauterine life. MMP-9 was immunolocalized in the villi goblet cells and in the lamina propria in cells identified as being the mast cells (a.b.). We concluded that in the i.u. and a.b. life the MMP-2 and MMP-9 were not expressed in the small intestine epithelium. However, after birth, because MMP-9 was expressed in the mast cels present in the lamina propria it may be involved in the remodeling process of the innate immunity that occurs during the small intestine development.

scholarly journals Signal Transduction Pathways Activated by Innate Immunity in Mast Cells: Translating Sensing of Changes into Specific Responses

Cells ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 2411 ◽  
Author(s):  
Zyanya P. Espinosa-Riquer ◽  
Deisy Segura-Villalobos ◽  
Itzel G. Ramírez-Moreno ◽  
Marian Jesabel Pérez Rodríguez ◽  
Mónica Lamas ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Mast Cells ◽  
Signaling Pathways ◽  
Cell Lineage ◽  
Negative Control ◽  
Type I ◽  
Control Mechanisms ◽  
Cell Type ◽  
And Function ◽  
Type I Hypersensitivity

Mast cells (MCs) constitute an essential cell lineage that participates in innate and adaptive immune responses and whose phenotype and function are influenced by tissue-specific conditions. Their mechanisms of activation in type I hypersensitivity reactions have been the subject of multiple studies, but the signaling pathways behind their activation by innate immunity stimuli are not so well described. Here, we review the recent evidence regarding the main molecular elements and signaling pathways connecting the innate immune receptors and hypoxic microenvironment to cytokine synthesis and the secretion of soluble or exosome-contained mediators in this cell type. When known, the positive and negative control mechanisms of those pathways are presented, together with their possible implications for the understanding of mast cell-driven chronic inflammation. Finally, we discuss the relevance of the knowledge about signaling in this cell type in the recognition of MCs as central elements on innate immunity, whose remarkable plasticity converts them in sensors of micro-environmental discontinuities and controllers of tissue homeostasis.

Mast cells in innate immunity

2004 ◽  
Vol 114 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Jean S Marshall ◽  
Dunia M Jawdat
Keyword(s):  
Innate Immunity ◽  
Mast Cells

scholarly journals The Role of Mast Cells in Innate Immunity

2003 ◽  
pp. 361-386
Author(s):  
Joshua A. Boyce ◽  
K. Frank Austen
Keyword(s):  
Innate Immunity ◽  
Mast Cells

Potential therapeutic use of IL-37: a key suppressor of innate immunity and allergic immune responses mediated by mast cells

2017 ◽  
Vol 65 (5) ◽  
pp. 982-986 ◽  
Author(s):  
Pio Conti ◽  
Francesco Carinci ◽  
Gianfranco Lessiani ◽  
Enrico Spinas ◽  
Spyridon K. Kritas ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Mast Cells ◽  
Immune Responses ◽  
Therapeutic Use

scholarly journals Mast Cells in Early Rheumatoid Arthritis

2019 ◽  
Vol 20 (8) ◽  
pp. 2040 ◽  
Author(s):  
Felice Rivellese ◽  
Francesca Wanda Rossi ◽  
Maria Rosaria Galdiero ◽  
Costantino Pitzalis ◽  
Amato de Paulis
Keyword(s):  
Rheumatoid Arthritis ◽  
Innate Immunity ◽  
Mast Cells ◽  
Autoimmune Disease ◽  
Animal Models ◽  
Immune Cells ◽  
Systemic Autoimmune Disease ◽  
Disease Development ◽  
Early Ra ◽  
Contradictory Data

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by inflammation of the synovial membrane, with thickening of the synovial layer, cellular hyperplasia, and infiltration of immune cells. Mast cells (MCs) are cells of the innate immunity present in healthy synovia and part of the cellular hyperplasia characterizing RA synovitis. Although their presence in synovia has been well described, the exact functions and the correlation of MCs with disease development and progression have been debated, particularly because of contradictory data obtained in animal models and from patients with longstanding disease. Here, we present a revision of the literature on MCs in RA, including the most recent observations obtained from patients with early RA, indicating MCs as relevant markers of disease severity in early RA.

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