Identification of Novel VEB β-Lactamase Enzymes and Their Impact on Avibactam Inhibition
2016 ◽
Vol 60
(5)
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pp. 3183-3186
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Keyword(s):
Class A
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ABSTRACTCeftazidime-avibactam has activity againstPseudomonas aeruginosaandEnterobacteriaceaeexpressing numerous class A and class C β-lactamases, although the ability to inhibit many minor enzyme variants has not been established. Novel VEB class A β-lactamases were identified during characterization of surveillance isolates. The cloned novel VEB β-lactamases possessed an extended-spectrum β-lactamase phenotype and were inhibited by avibactam in a concentration-dependent manner. The residues that comprised the avibactam binding pocket were either identical or functionally conserved. These data demonstrate that avibactam can inhibit VEB β-lactamases.
2011 ◽
Vol 55
(6)
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pp. 2710-2713
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2010 ◽
Vol 65
(5)
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pp. 866-871
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2012 ◽
Vol 56
(12)
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pp. 6212-6222
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