scholarly journals Impact of Empirical-Therapy Selection on Outcomes of Intravenous Drug Users with Infective Endocarditis Caused by Methicillin-Susceptible Staphylococcus aureus

2007 ◽  
Vol 51 (10) ◽  
pp. 3731-3733 ◽  
Author(s):  
Thomas P. Lodise ◽  
Peggy S. McKinnon ◽  
Donald P. Levine ◽  
Michael J. Rybak
Keyword(s):  
Staphylococcus Aureus ◽  
Regression Analysis ◽  
Infective Endocarditis ◽  
Clinical Characteristics ◽  
Drug Users ◽  
Empirical Therapy ◽  
Intravenous Drug ◽  
Intravenous Drug Users ◽  
Beta Lactam ◽  
Related Mortality

ABSTRACT This study compares beta-lactam and vancomycin among intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureus. Patients who received vancomycin had higher infection-related mortality, even if they were switched to beta-lactam once culture results became available; this relationship persisted after logistic regression analysis controlling for clinical characteristics.

scholarly journals 698. 8 Years of Infective Endocarditis in Intravenous and Non-Intravenous Drug Users a Single Center Experience

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S400-S401
Author(s):  
Rodolfo M Alpizar-Rivas ◽  
Javier Balda ◽  
Salwa Elarabi ◽  
Bertrand Jaber ◽  
Claudia Nader
Keyword(s):  
Staphylococcus Aureus ◽  
Infective Endocarditis ◽  
Drug Users ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Intravenous Drug ◽  
Coagulase Negative Staphylococcus ◽  
Intravenous Drug Users ◽  
Single Center ◽  
Methicillin Resistant ◽  
Single Center Experience

Abstract Background Despite advances in diagnosis and management, infective endocarditis (IE) is associated with considerable morbidity and mortality. Given the emergence of drug- resistant organisms, it is unclear whether this has impacted the characteristics and outcomes of IE among intravenous drug users (IDUs) and non-IDUs. Methods We conducted a single center retrospective cohort study. 306 records of hospitalized adults diagnose with IE by ICD-9/ICD-10 codes were identified from 2011 to 2018. 244 patients met criteria. IRB approval was obtained. The baseline demographic, microbiologic, echocardiographic variables and outcomes were extracted from the chart, and compared between IDUs and non-IDUs. Results 112 (45.9%) patients were IDUs and significantly younger (mean age 36 vs. 64, p< 0.001). Both methicillin-sensitive (44.6% vs. 23.5%, p< 0.001) and methicillin-resistant (29.5% vs. 13.6%, p= 0.002) Staphylococcus aureus associated IE were more prevalent in IDUs compared to non-IDUs. Streptococcus species (22.7% vs 11.6%, p=0.02), excluding Enterococcus species, and coagulase-negative Staphylococcus (12.1% vs 1.8%, p=0.002) were significantly more prevalent in non-IDUs. IE in IDUs were more likely to have tricuspid valve vegetations (56.3% vs. 13.6%, p< 0.001), whereas non-IDUs were more likely to have mitral valve (39.4% vs. 25%, p=0.02) and aortic valve vegetations (46.2% vs. 15.2%, p< 0.001). 19% of patients with IE underwent valve replacement within 6 months, and 17% died within 90 days. A multivariable model that included age, gender, and IDU status, age was the only variable that remained independently associated with 90-day mortality (adjusted OR 1.031; 95% CI 1.006, 1.057; p< 0.01). Conclusion In this single-center experience, we found that methicillin-sensitive Staphylococcus aureus was the dominant organism among IDUs and non-IDUs. We also found that methicillin-resistant Staphylococcus aureus was significantly more prevalent among IDUs with IE. Provably related to an increase prevalence of colonization with resistant organisms in the community. Despite the shift in prevalence of methicillin-resistant Staphylococcus aureus among IDUs, there was no increased 90-day mortality risk after adjustment for age and gender. Disclosures All Authors: No reported disclosures

Infective Endocarditis in Intravenous Drug Users from Italy: the Increasing Importance in HIV-infected Patients

Infection ◽  
2007 ◽  
Vol 35 (3) ◽  
pp. 154-160 ◽  
Author(s):  
F. G. De Rosa ◽  
S. Cicalini ◽  
F. Canta ◽  
S. Audagnotto ◽  
E. Cecchi ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Drug Users ◽  
Intravenous Drug ◽  
Intravenous Drug Users

Epidemiological Analysis of Infective Endocarditis in a Major Tertiary Centre: A Comparison Between Intravenous Drug Users and Non-Intravenous Drug Users Over a Six-Year Period

2018 ◽  
Vol 27 ◽  
pp. S315-S316 ◽  
Author(s):  
J. Yoon ◽  
J. Ramnarain ◽  
P. Sivabalan ◽  
P. Simos ◽  
M. Chatfield ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Drug Users ◽  
Intravenous Drug ◽  
Intravenous Drug Users ◽  
Epidemiological Analysis ◽  
Tertiary Centre

Infective Endocarditis in Intravenous Drug Users—a Modern Outlook

2019 ◽  
Vol 7 (3) ◽  
pp. 107-110
Author(s):  
Ashwin Vaidyanathan ◽  
Sarah Money
Keyword(s):  
Infective Endocarditis ◽  
Drug Users ◽  
Intravenous Drug ◽  
Intravenous Drug Users

scholarly journals Infective endocarditis in intravenous drug users in Europe: A clean start?

2020 ◽  
Vol 160 (3) ◽  
pp. e131 ◽  
Author(s):  
Nick Chilvers ◽  
Stephen C. Clark
Keyword(s):  
Infective Endocarditis ◽  
Drug Users ◽  
Intravenous Drug ◽  
Intravenous Drug Users

scholarly journals Surgical and Medical Management of Isolated Tricuspid Valve Infective Endocarditis in Intravenous Drug Users

2015 ◽  
Vol 31 (2) ◽  
pp. 83-88 ◽  
Author(s):  
Nabha Shetty ◽  
Dave Nagpal ◽  
Sharon Koivu ◽  
Marko Mrkobrada
Keyword(s):  
Infective Endocarditis ◽  
Tricuspid Valve ◽  
Medical Management ◽  
Drug Users ◽  
Intravenous Drug ◽  
Intravenous Drug Users

Long-Term Outcome for the Surgical Treatment of Infective Endocarditis With a Focus on Intravenous Drug Users

2012 ◽  
Vol 93 (1) ◽  
pp. 51-57 ◽  
Author(s):  
David G. Rabkin ◽  
Nahush A. Mokadam ◽  
Donald W. Miller ◽  
Raymond R. Goetz ◽  
Edward D. Verrier ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Infective Endocarditis ◽  
Drug Users ◽  
Intravenous Drug ◽  
Intravenous Drug Users ◽  
Term Outcome ◽  
Long Term Outcome
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