Activity of Antimicrobial Combinations against KPC-2-Producing Klebsiella pneumoniae in a Rat Model and Time-Kill Assay
2015 ◽
Vol 59
(7)
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pp. 4301-4304
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ABSTRACTThis study evaluated the efficacy of tigecycline (TIG), polymyxin B (PMB), and meropenem (MER) in 80 rats challenged withKlebsiella pneumoniaecarbapenemase (KPC)-producingK. pneumoniaeinfection. A time-kill assay was performed with the same strain. Triple therapy and PMB+TIG were synergistic, promoted 100% survival, and produced negative peritoneal cultures, while MER+TIG showed lower survival and higher culture positivity than other regimens (P= 0.018) and was antagonistic.In vivoandin vitrostudies showed that combined regimens, except MER+TIG, were more effective than monotherapies for this KPC-producing strain.
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2016 ◽
Vol 60
(5)
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pp. 3001-3006
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2015 ◽
Vol 59
(6)
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pp. 3596-3597
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2020 ◽
Vol 55
(1)
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pp. 105852
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2019 ◽
Vol 74
(11)
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pp. 3211-3216
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2014 ◽
Vol 59
(3)
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pp. 1797-1801
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