In Vitro Synergy and In Vivo Activity of Tigecycline-Ciprofloxacin Combination Therapy against Vibrio vulnificus Sepsis
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ABSTRACT The mortality rate associated with Vibrio vulnificus sepsis remains high. An in vitro time-kill assay revealed synergism between tigecycline and ciprofloxacin. The survival rate was significantly higher in mice treated with tigecycline plus ciprofloxacin than in mice treated with cefotaxime plus minocycline. Thus, combination treatment with tigecycline-ciprofloxacin may be an effective novel antibiotic regimen for V. vulnificus sepsis.
2011 ◽
Vol 55
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pp. 2755-2759
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2019 ◽
Vol 74
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pp. 3211-3216
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2014 ◽
Vol 59
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pp. 1797-1801
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2011 ◽
Vol 56
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pp. 202-207
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2016 ◽
Vol 60
(5)
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pp. 3001-3006
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2019 ◽