LmrS Is a Multidrug Efflux Pump of the Major Facilitator Superfamily from Staphylococcus aureus
2010 ◽
Vol 54
(12)
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pp. 5406-5412
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Keyword(s):
ABSTRACT A multidrug efflux pump designated LmrS (lincomycin resistance protein of Staphylococcus aureus), belonging to the major facilitator superfamily (MFS) of transporters, was cloned, and the role of LmrS in antimicrobial efflux was evaluated. The highest relative increase in MIC, 16-fold, was observed for linezolid and tetraphenylphosphonium chloride (TPCL), followed by an 8-fold increase for sodium dodecyl sulfate (SDS), trimethoprim, and chloramphenicol. LmrS has 14 predicted membrane-spanning domains and is homologous to putative lincomycin resistance proteins of Bacillus spp., Lactobacillus spp., and Listeria spp.
2009 ◽
Vol 191
(12)
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pp. 903-911
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2011 ◽
Vol 77
(9)
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pp. 2855-2862
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2001 ◽
Vol 45
(4)
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pp. 1126-1136
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2000 ◽
Vol 13
(5)
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pp. 572-577
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2006 ◽
Vol 50
(4)
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pp. 1276-1281
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2002 ◽
Vol 20
(3)
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pp. 206-213
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Keyword(s):