KPC-39-mediated resistance to Ceftazidime-Avibactam in a
Klebsiella pneumoniae
ST307 clinical isolate
Keyword(s):
Resistance to ceftazidime–avibactam (CAZ-AVI) combination is being increasingly reported. Here, we report a CAZ-AVI resistant Klebsiella pneumoniae belonging to the high-risk ST307 clone and producing KPC-39, a single amino-acid variant of KPC-3 (A172T). Cloning experiments, steady state kinetic parameters and molecular dynamics simulations revealed a loss of carbapenemase activity and an increased affinity for ceftazidime. KPC-39 was identified in a patient without prior exposure to CAZ-AVI, suggesting silent dissemination in European healthcare settings.
1976 ◽
Vol 251
(7)
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pp. 2023-2029
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1983 ◽
Vol 258
(13)
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pp. 8156-8162
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1975 ◽
Vol 250
(7)
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pp. 2709-2717
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1991 ◽
Vol 266
(32)
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pp. 21616-21625
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1981 ◽
Vol 256
(16)
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pp. 8845-8849
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1986 ◽
Vol 261
(13)
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pp. 5936-5942
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1982 ◽
Vol 257
(2)
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pp. 924-929
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Steady state kinetic parameters for the thrombin-catalyzed conversion of human fibrinogen to fibrin.
1983 ◽
Vol 258
(15)
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pp. 9276-9282
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1979 ◽
Vol 254
(18)
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pp. 9142-9147
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1979 ◽
Vol 254
(19)
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pp. 9807-9813
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