Molecular Characterization of the CytochromebGene andIn VitroAtovaquone Susceptibility of Plasmodium falciparum Isolates from Kenya
2015 ◽
Vol 59
(3)
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pp. 1818-1821
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Keyword(s):
ABSTRACTThe prevalence of a genetic polymorphism(s) at codon 268 in the cytochromebgene, which is associated with failure of atovaquone-proguanil treatment, was analyzed in 227Plasmodium falciparumparasites from western Kenya. The prevalence of the wild-type allele was 63%, and that of the Y268S (denoting a Y-to-S change at position 268) mutant allele was 2%. There were no pure Y268C or Y268N mutant alleles, only mixtures of a mutant allele(s) with the wild type. There was a correlation between parasite 50% inhibitory concentration (IC50) and parasite genetic polymorphism; mutant alleles had higher IC50s than the wild type.
2015 ◽
Vol 59
(12)
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pp. 7540-7547
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2014 ◽
Vol 59
(1)
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pp. 730-733
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Keyword(s):
2015 ◽
Vol 59
(7)
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pp. 3995-4002
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2014 ◽
Vol 58
(6)
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pp. 3389-3398
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Keyword(s):
2011 ◽
Vol 180
(1)
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pp. 1-7
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2012 ◽
Vol 79
(2)
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pp. 449-459
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2020 ◽