Efficacy of Posaconazole in Murine Experimental Sporotrichosis
2012 ◽
Vol 56
(5)
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pp. 2273-2277
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Keyword(s):
ABSTRACTWe developed a murine model of systemic sporotrichosis by using three strains of each of the two commonest species causing sporotrichosis, i.e.,Sporothrix schenckiisensu stricto andSporothrix brasiliensis, in order to evaluate the efficacy of posaconazole (PSC). The drug was administered at a dose of 2.5 or 5 mg/kg of body weight twice a day by gavage, and one group was treated with amphotericin B (AMB) as a control treatment. Posaconazole, especially at 5 mg/kg, showed good efficacy against all the strains tested, regardless of their MICs, as measured by prolonged survival, tissue burden reduction, and histopathology.
2015 ◽
Vol 59
(8)
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pp. 5018-5021
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Keyword(s):
2015 ◽
Vol 60
(1)
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pp. 296-300
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Keyword(s):
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2010 ◽
Vol 54
(10)
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pp. 4074-4077
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Keyword(s):
2008 ◽
Vol 52
(10)
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pp. 3786-3788
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Keyword(s):
2013 ◽
Vol 57
(9)
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pp. 4540-4542
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Keyword(s):
2003 ◽
Vol 47
(10)
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pp. 3343-3344
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2003 ◽
Vol 47
(6)
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pp. 1948-1951
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Keyword(s):
2005 ◽
Vol 49
(11)
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pp. 4757-4759
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Keyword(s):