scholarly journals Efficacy of Albaconazole (UR-9825) in Treatment of Disseminated Scedosporium prolificans Infection in Rabbits

2003 ◽  
Vol 47 (6) ◽  
pp. 1948-1951 ◽  
Author(s):  
Javier Capilla ◽  
Clara Yustes ◽  
Emili Mayayo ◽  
Belkys Fernández ◽  
Montserrat Ortoneda ◽  
...  
Keyword(s):  
Body Weight ◽  
Amphotericin B ◽  
Rabbit Model ◽  
Systemic Infection ◽  
Control Group ◽  
Scedosporium Prolificans ◽  
Tissue Burden

ABSTRACT There are no effective therapeutics for treating invasive Scedosporium prolificans infections. Doses of 15, 25, and 50 mg/kg of body weight/day for the new triazole albaconazole (ABC) were evaluated in an immunocompetent rabbit model of systemic infection with this mold. Treatments were begun 1 day after challenge and given for 10 days. ABC at any dose was more effective than amphotericin B (AMB) at 0.8 mg/kg/day at clearing S. prolificans from tissue (P < 0.007). The percentages of survival at 25 mg of ABC/kg/day were similar to those obtained with AMB. Rabbits showed 100% survival when they were treated with 50 mg of ABC per kg (P < 0.0001 versus control group), and only this dosage was able to reduce tissue burden significantly in the five organs studied, i.e., spleen, kidneys, liver, lungs, and brain.

scholarly journals Antifungal Therapy in a Murine Model of Disseminated Infection by Cryptococcus gattii

2010 ◽  
Vol 54 (10) ◽  
pp. 4074-4077 ◽  
Author(s):  
Enrique Calvo ◽  
F. Javier Pastor ◽  
M. Mar Rodríguez ◽  
Isabel Pujol ◽  
Josep Guarro
Keyword(s):  
Body Weight ◽  
Brain Tissue ◽  
Amphotericin B ◽  
Murine Model ◽  
Systemic Infection ◽  
Cryptococcus Gattii ◽  
Pulmonary Cryptococcosis ◽  
Fungistatic Activity ◽  
Fungal Load ◽  
Tissue Burden

ABSTRACT We have evaluated the efficacy of posaconazole (PSC), voriconazole (VRC), and amphotericin B (AMB) in a murine model of systemic infection by Cryptococcus gattii using immunocompromised animals and three clinical strains of the fungus. AMB was the most effective drug in prolonging the survival of mice and also in reducing tissue burden in all organs tested. To a lesser degree, VRC at 60 mg/kg of body weight in lung tissue and PSC at 40 mg/kg also in spleen demonstrated good efficacy in reducing the fungal load. The PSC and VRC levels in serum and brain tissue, determined by an agar diffusion bioassay method at 4 h after the last dose of the therapy, were above the corresponding MIC values. However, these drugs were not able to reduce the fungal load in brain tissue. Our results demonstrated that PSC and, to a lesser degree, VRC, have fungistatic activity and potential for the treatment of human pulmonary cryptococcosis.

scholarly journals Efficacy of Voriconazole in a Guinea Pig Model of Invasive Trichosporonosis

2006 ◽  
Vol 50 (6) ◽  
pp. 2240-2243 ◽  
Author(s):  
Carolina Serena ◽  
Félix Gilgado ◽  
Marçal Mariné ◽  
F. Javier Pastor ◽  
Josep Guarro
Keyword(s):  
Body Weight ◽  
Guinea Pig ◽  
Amphotericin B ◽  
Guinea Pigs ◽  
Systemic Infection ◽  
Pig Model ◽  
Trichosporon Asahii ◽  
Tissue Burden ◽  
Guinea Pig Model

ABSTRACT We have evaluated the efficacy of voriconazole (VRC) in a systemic infection by Trichosporon asahii in immunosuppressed guinea pigs. VRC was more effective than amphotericin B in prolonging survival and reducing tissue burden. The best results were obtained with VRC at 10 mg/kg of body weight/day.

scholarly journals Treatment of Murine Fusariosis with SCH 56592

1999 ◽  
Vol 43 (3) ◽  
pp. 589-591 ◽  
Author(s):  
M. Lozano-Chiu ◽  
S. Arikan ◽  
V. L. Paetznick ◽  
E. J. Anaissie ◽  
D. Loebenberg ◽  
...  
Keyword(s):  
Body Weight ◽  
Amphotericin B ◽  
Fusarium Solani ◽  
Antifungal Agent ◽  
Systemic Infection ◽  
Immunocompetent Mice ◽  
Systemic Infections ◽  
Organ Clearance

ABSTRACT Doses of 10 to 100 mg of the azole antifungal agent SCH 56592/kg of body weight/day were studied in immunocompetent mice as therapy for systemic infection by Fusarium solani. Treatment was begun 1 h after intravenous infection and continued daily for 4 or 13 doses. Prolongation of survival and organ clearance were dependent on both the dose and the duration of SCH 56592 therapy, with the best results seen at 50 and 100 mg/kg/day. The results at the highest doses of SCH 56592 used (50 or 100 mg/kg/day) were comparable to those obtained with amphotericin B at 1 mg/kg/day. SCH 56592 has potential for therapy of systemic infections caused byF. solani.

scholarly journals In Vivo Activity of Posaconazole against Mucor spp. in an Immunosuppressed-Mouse Model

2002 ◽  
Vol 46 (7) ◽  
pp. 2310-2312 ◽  
Author(s):  
Qiu N. Sun ◽  
Laura K. Najvar ◽  
Rosie Bocanegra ◽  
David Loebenberg ◽  
John R. Graybill
Keyword(s):  
Body Weight ◽  
Mouse Model ◽  
Amphotericin B ◽  
Immunosuppressed Mouse ◽  
Tissue Burden

ABSTRACT The in vivo activities of posaconazole, itraconazole, and amphotericin B in neutropenic mice with zygomycosis were compared. The in vitro MICs of posaconazole and itraconazole for the strains of Mucor spp. used in this study ranged from 0.125 to 8 μg/ml and 0.25 to 8 μg/ml, respectively. The in vitro MIC range for amphotericin B is 0.125 to 0.25 μg/ml. At twice-daily doses of ≥15 mg/kg of body weight, posaconazole prolonged the survival of the mice and reduced tissue burden.

scholarly journals Antidiabetogenic impact of bitter melon (Momordica charantia) and garlic (Allium sativum) on alloxan induced diabetic rabbit model

2016 ◽  
Vol 2 (3) ◽  
pp. 402-408
Author(s):  
Ambiara ◽  
Fahima Binthe Aziz ◽  
Md Mahmudul Hasan ◽  
Md Shajedur Rahman ◽  
Misrat Masuma Parvez ◽  
...  
Keyword(s):  
Body Weight ◽  
Glucose Level ◽  
Combined Treatment ◽  
Rabbit Model ◽  
Treated Group ◽  
Control Group ◽  
Bitter Melon ◽  
Diabetic Rabbit ◽  
Group A ◽  
Group B

The present study was undertaken to investigate the antidiabetic effect of the Bitter melon and Garlic on Alloxan induced diabetes in experimental rabbits. At 2 to 3 months of age, rabbits were assigned into five groups (A, B, C, D and E) and each group was remained 4 rabbits. Group A was kept for control, Group B was treated with Alloxanintramuscullarly at a dose of 75mg /kg body weight, Group C was treated with bitter melon 250gm/kg body weight orally, Group D was treated with garlic 750mg/kg body weight orally, Group E treated with combined at previous dose. After acclimatization, diabetes was induced in four groups of rabbits (B, C, D and E) by administering Alloxan injection in a dose of 75mg/kg body weight (b.wt.) intramuscularlly. There was significant decreased in blood glucose level in all treated group C, D, E compared to the B group and lowest glucose was recorded in E group when treated with combined medicinal herbs and body weight was increased in all treated group C, D, E compared to the B group and highest was recorded in Dgroup while treated with those.% of PCV level and Hb gm/dl concentration was the highest in group E which was treated with both garlic and bitter melon compare to the A group. ESR was highest in group B treated with Alloxan and lowest in group E. The present study reveals that combined treatment increases body weight and decreases glucose level without affecting health of rabbits.Asian J. Med. Biol. Res. September 2016, 2(3): 402-408

scholarly journals Efficacy of Voriconazole in Treatment of Systemic Scedosporiosis in Neutropenic Mice

2003 ◽  
Vol 47 (12) ◽  
pp. 3976-3978 ◽  
Author(s):  
Javier Capilla ◽  
Carolina Serena ◽  
F. Javier Pastor ◽  
Montserrat Ortoneda ◽  
Josep Guarro
Keyword(s):  
Murine Model ◽  
Systemic Infection ◽  
Control Group ◽  
Scedosporium Apiospermum ◽  
Tissue Burden

ABSTRACT We have evaluated the efficacy of voriconazole (VRC) in a murine model of systemic infection by Scedosporium apiospermum. The survival of mice treated with VRC at 5, 20, or 40 mg/kg/day was greater than that of the control group (P ≤ 0.0009). VRC reduced the tissue burden in the spleen and brain (P < 0.001 in both organs) in comparison with that of the control group.

scholarly journals Efficacy of Liposomal Amphotericin B in Treatment of Systemic Murine Fusariosis

2002 ◽  
Vol 46 (7) ◽  
pp. 2273-2275 ◽  
Author(s):  
Montserrat Ortoneda ◽  
Javier Capilla ◽  
Francisco J. Pastor ◽  
Isabel Pujol ◽  
Josep Guarro
Keyword(s):  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
Fusarium Verticillioides ◽  
Systemic Infection ◽  
Liposomal Amphotericin B ◽  
Amphotericin B Deoxycholate ◽  
Tissue Burden

ABSTRACT We have compared the activities of liposomal amphotericin B (LAMB) at 3, 5, 10, and 20 mg/kg/day and amphotericin B deoxycholate (AMB) at 1.5 and 2.5 mg/kg/day in a murine systemic infection by Fusarium verticillioides. Survival was improved by all treatments except AMB at 1.5 mg/kg/day. The tissue burden in liver was reduced by LAMB at all dosages and by AMB at 2.5 mg/kg/day. The two highest dosages of LAMB showed significant reductions in the spleen.

scholarly journals Posaconazole Combined with Amphotericin B, an Effective Therapy for a Murine Disseminated Infection Caused by Rhizopus oryzae

2008 ◽  
Vol 52 (10) ◽  
pp. 3786-3788 ◽  
Author(s):  
M. Mar Rodríguez ◽  
Carolina Serena ◽  
Marçal Mariné ◽  
F. Javier Pastor ◽  
Josep Guarro
Keyword(s):  
Body Weight ◽  
Amphotericin B ◽  
Murine Model ◽  
Rhizopus Oryzae ◽  
Effective Therapy ◽  
Prolonged Survival ◽  
Low Doses ◽  
Disseminated Infection ◽  
Tissue Burden

ABSTRACT In a murine model of disseminated zygomycosis, low doses of amphotericin B (0.3 mg/kg body weight/day) combined with posaconazole (40 mg/kg/day) prolonged survival and reduced tissue burden with respect to that of controls and that of both drugs administered alone. Results were similar to those obtained with amphotericin B given alone at 0.8 mg/kg/day.

scholarly journals Efficacy of UK-109496, a new azole antifungal agent, in an experimental model of invasive aspergillosis.

1996 ◽  
Vol 40 (1) ◽  
pp. 86-91 ◽  
Author(s):  
D George ◽  
P Miniter ◽  
V T Andriole
Keyword(s):  
Body Weight ◽  
Invasive Aspergillosis ◽  
Aspergillus Fumigatus ◽  
Antifungal Agent ◽  
Half Life ◽  
Oral Therapy ◽  
Rabbit Model ◽  
Circulating Antigen ◽  
Liver And Kidney ◽  
Tissue Burden

The efficacy of UK-109496, a new azole antifungal agent, was evaluated in an immunosuppressed, temporarily leukopenic rabbit model of invasive aspergillosis. Oral therapy with UK-109496 at a dosage of 10 or 15 mg/kg of body weight every 8 h was begun 24 h after a lethal or sublethal challenge, and results were compared with those for amphotericin B therapy and untreated controls. UK-109496 eliminated mortality and also reduced the tissue burden of Aspergillus fumigatus 10- to 100-fold in liver and kidney tissues and to a lesser degree in lung tissue, and at the higher dose, no viable organisms were recovered from brain tissue from these animals. Both dosages of UK-109496 decreased or eliminated circulating antigen. The half-life of UK-109496 in rabbits was 2.5 to 3 h, and no accumulation of drug was seen even after 15 doses in either uninfected or infected animals. Thus, UK-109496 shows activity in this rabbit model of invasive aspergillosis. Additional studies are needed to determine the potential of the drug for use in the treatment of this infection.

scholarly journals Efficacy of Posaconazole in a Murine Disseminated Infection by Candida tropicalis

2009 ◽  
Vol 54 (1) ◽  
pp. 530-532 ◽  
Author(s):  
Marçal Mariné ◽  
F. Javier Pastor ◽  
Josep Guarro
Keyword(s):  
Body Weight ◽  
Candida Tropicalis ◽  
Systemic Infection ◽  
Infection Model ◽  
Disseminated Infection ◽  
Tissue Burden ◽  
Fungal Tissue ◽  
Immunosuppressed Mice

ABSTRACT We evaluated the efficacy of posaconazole against Candida tropicalis in a systemic infection model with immunosuppressed mice. Posaconazole at 50 mg/kg of body weight/day prolonged the survival of mice and reduced the fungal tissue burden of mice infected with any of the five strains tested, with the exception of one strain that had a high MIC against this drug. Our results demonstrate the efficacy of posaconazole in the treatment of invasive murine infection caused by C. tropicalis.

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