scholarly journals Pharmacokinetics of high-dose intravenous ciprofloxacin in young and elderly and in male and female subjects.

1995 ◽  
Vol 39 (4) ◽  
pp. 1003-1006 ◽  
Author(s):  
A Shah ◽  
J Lettieri ◽  
D Nix ◽  
J Wilton ◽  
A H Heller
Keyword(s):  
Healthy Volunteer ◽  
The Elderly ◽  
Pharmacokinetic Parameters ◽  
High Dose ◽  
Age And Gender ◽  
Male And Female ◽  
Volunteer Study ◽  
Healthy Volunteer Study ◽  
Local Reactions ◽  
And Gender

The effects of age and gender on the pharmacokinetics of high-dose intravenous ciprofloxacin in a healthy volunteer study were investigated. Plasma ciprofloxacin concentrations were higher in the elderly than in the young, and the pharmacokinetic parameters were not significantly different between the genders. Ciprofloxacin was well tolerated, with the majority of adverse events related to local reactions at the IV site.

scholarly journals Absence of age and gender effects on the pharmacokinetics of a single 500-milligram oral dose of levofloxacin in healthy subjects.

1997 ◽  
Vol 41 (7) ◽  
pp. 1562-1565 ◽  
Author(s):  
S C Chien ◽  
A T Chow ◽  
J Natarajan ◽  
R R Williams ◽  
F A Wong ◽  
...  
Keyword(s):  
Renal Function ◽  
Healthy Subjects ◽  
Age Groups ◽  
The Elderly ◽  
Gender Effects ◽  
Pharmacokinetic Parameters ◽  
Age And Gender ◽  
Male And Female ◽  
Young Males ◽  
And Gender

The influence of age and gender on the pharmacokinetics of levofloxacin in healthy subjects receiving a single oral 500-mg dose of levofloxacin was investigated in this parallel design study. Six young males (aged 18 to 40 years), six elderly males (aged > or = 65 years), six young females (aged 18 to 40 years), and six elderly females (aged > or = 65 years) were enrolled and completed the study. The study reveals that the bioavailability (rate and extent) of levofloxacin was not affected by either age or gender. In both age (young and elderly) and gender (male and female) groups of subjects, peak concentrations in plasma were reached at approximately 1.5 h after dosing; renal clearance of levofloxacin accounted for approximately 77% of total body clearance, and approximately 76% of the administered dose was recovered unchanged in urine over the 36 h of collection. The apparent differences in the calculated pharmacokinetic parameters for levofloxacin between the age groups (young versus elderly) and between the gender groups (males versus females) could be explained by differences in renal function among the subjects. A single dose of 500 mg of levofloxacin administered orally to both young and old, male and female healthy subjects was found to be safe and well tolerated. As the differences in levofloxacin kinetics between the young and the elderly or the males and the females are limited and are mainly related to the renal function of the subjects, dose adjustment based on age or gender alone is not necessary.

scholarly journals Native myocardial T1 and ECV with age and gender developing normal reference ranges - a 94 healthy volunteer study

2016 ◽  
Vol 18 (Suppl 1) ◽  
pp. O42 ◽  
Author(s):  
Stefania Rosmini ◽  
Heerajnarain Bulluck ◽  
Thomas A Treibel ◽  
Amna Abdel-Gadir ◽  
Anish N Bhuva ◽  
...  
Keyword(s):  
Healthy Volunteer ◽  
Reference Ranges ◽  
Age And Gender ◽  
Normal Reference ◽  
Volunteer Study ◽  
Healthy Volunteer Study ◽  
Myocardial T1 ◽  
And Gender

Abstract A57: High‐dose resveratrol modulates drug and carcinogen metabolizing enzymes in a healthy volunteer study

2010 ◽  
Author(s):  
H‐H Sherry Chow ◽  
Linda Garland ◽  
Chiu‐Hsieh Hsu ◽  
Donna Vining ◽  
Wade Chew ◽  
...  
Keyword(s):  
Healthy Volunteer ◽  
High Dose ◽  
Metabolizing Enzymes ◽  
Volunteer Study ◽  
Healthy Volunteer Study

scholarly journals Profile of Colorectal Tumor in Gastroentero-Hepatology Center, Department of Internal Medicine, Dr Soetomo Hospital, Surabaya

2020 ◽  
Vol 56 (1) ◽  
pp. 15
Author(s):  
Husin Thamrin ◽  
Khafidhotul Ilmiah ◽  
Ni Wajan Tirthaningsih
Keyword(s):  
Colorectal Cancer ◽  
Medical Records ◽  
Colorectal Tumor ◽  
Age And Gender ◽  
Male And Female ◽  
The Third ◽  
Common Cancer ◽  
Significant Difference ◽  
And Gender ◽  
Ethical Clearance

Colorectal cancer has became burden in the world.The latest study shows that colorectal cancer is the third most common cancer in men and second most common cancer in women globally. There are difference characteristic of epidemiology in every countries. Moreover, there is no study that represents epidemiology of colorectal cancer in Indonesia yet, especially in East Java. The aim of this study was to describe colorectal tumor profile by age and gender in Gastroentero-Hepatology Center, Dr Soetomo Hospital. This study has received a certificate of Ethical Clearance No.273/Panke.KKE/IV/2015, a descriptive retrospective study. We collected data using medical records, and patients who have been colonoscopy examination and suspected colorectal tumor were included. There were 201 patients, divided to 100 males and 101 females. The peak of incidence was on 51-60 years old group, but on the 31-40 years old incidence of colorectal tumor was increased. The youngest patient was 17 years old. And tumors are more likely develop in distal area, especially in rectum. This study shows a different characteristic profile of colorectal tumor, where tumor is developed at young people and there is no significant difference between male and female for the incidence.

scholarly journals AGE AND GENDER WISE DISTRIBUTIONOF RISK FACTORS AMONG PATIENTS WITHCORONORY ARTERY DISEASE.

1969 ◽  
Vol 4 (2) ◽  
pp. 523-528
Author(s):  
MUHAMMAD ASIF IQBAL ◽  
IKRAMULLAH ◽  
ABDUL HADI ◽  
FAROOQ AHMAD ◽  
MUHAMMAD REHANUL HAQ ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery ◽  
Older Age ◽  
Fat Intake ◽  
Conventional Risk Factor ◽  
Age And Gender ◽  
Male And Female ◽  
Artery Disease ◽  
And Gender ◽  
Conventional Risk Factors

OBJECTIVE: To describe conventional risk factors by age and gender in coronary artery diseasepatients.MATERIALS AND METHODS: This study was conducted in outdoor patient department of agencyheadquarter hospital (AHQ) Landikotal, Khyber agency, from June to October 2013. It was a hospitalbased descriptive observational study. Sample size was 926 patients with established coronary arterydisease, recruited through purposive convenient sampling technique. Adult patients (above 18 years) ofboth genders with coronary artery disease were included in the study. Every patient was evaluated forthe presence of conventional risk factors. Card vascular risk factors were assessed by a self-administeredquestionnaire and various laboratory tests.RESULTS: Total patients were 926, male were 546(59%). Mean age was 58.28±12.005 years (20-95years). Study population was divided into younger (age <40 years) and older age groups (> 40 years).Younger patients were 66(7.1%) and older age 866(92.9%). Hypertension was present in 563 patients(61.1%) with 59.2%and 63.2% in male and female, respectively (p=0.186). Diabetes was present in29.9% with 27.8% in male and 32.9% in female patients (p=0.098).Hypertension was significantly morecommon in older patients while smoking and heavy fat intake was significantly more common inyounger patients. Other risk factors for CAD were similar across younger and older age groups.CONCLUSION: Conventional risk factor in male and female differ widely with smoking, ex-smoker,heavy fat intake and obesity is significantly more common in male patients, while family history forCAD is common in female patients. Diabetes is higher in 40 years or above patients while smoking ishigher in patients less than 40 years.KEY WORDS: Conventional Risk Factor, Coronary Artery Disease, Age, Gender

scholarly journals Influence of Gender on Cardiac and Encephalic Inflammation in the Elderly with Cysticercosis: A Case Control Study

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
Camila Lourencini Cavellani ◽  
Rosana Rosa Miranda Corrêa ◽  
Mara Lúcia Fonseca Ferraz ◽  
Laura Penna Rocha ◽  
Ana Carolina Guimarães Faleiros ◽  
...  
Keyword(s):  
Inflammatory Infiltrate ◽  
Case Control Study ◽  
The Elderly ◽  
Brain Parenchyma ◽  
Elderly Group ◽  
University Hospital ◽  
Evolutionary Stage ◽  
Age And Gender ◽  
And Gender ◽  
Control Study

Background. The present study explores the influence of the host’s age and gender upon the inflammatory infiltrate. We aimed to quantify the inflammatory infiltrate caused by cysticercosis, which is related to aging, in the heart and in the encephalon.Methods. 75 autopsy protocols with cysticercosis diagnosis from department of pathology at a university hospital from 1970 to 2008 were reviewed. Two groups were formed: elderly with cysticercosis and nonelderly with cysticercosis. We used KS-300 (Kontron-Zeiss) software for morphometric analysis of the inflammation.Results.The elderly had an average of3.1±2.5cysticerci, whereas the non-elderly had2.7±3.8parasites. The non-elderly group with cysticercosis had significantly more inflammation, both cardiac and encephalic, than the elderly group. The elderly females with cysticercosis had more cardiac and encephalic inflammation.Conclusions. In this study, we showed that the non-elderly had significantly more cardiac and encephalic inflammation than the elderly, and that such inflammatory infiltrate decreases with age and depends upon the evolutionary stage of the cysticercus. Furthermore, there are differences concerning gender in the intensity of the inflammatory response due to cysticerci in the heart and brain parenchyma during senescence. Even during this period, women continue to have a more intense response to the parasitosis.

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