In Vitro Activities of StrychnosAlkaloids and Extracts against Plasmodium falciparum
1999 ◽
Vol 43
(9)
◽
pp. 2328-2331
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Keyword(s):
ABSTRACT The in vitro antimalarial activities of 46 alkaloids and extracts from Strychnos species were evaluated. Two types of quasidimeric alkaloids exhibit high and selective activities againstPlasmodium. Strychnopentamine and isostrychnopentamine were active against chloroquine-sensitive and -resistant strains (50% inhibitory concentration [IC50] ≈ 0.15 μM), while dihydrousambarensine exhibited a 30-fold higher activity against the chloroquine-resistant strain (IC50 = 0.03 μM) than it did against the chloroquine-sensitive strain.
Keyword(s):
2017 ◽
Vol 116
(7)
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pp. 1849-1854
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2004 ◽
Vol 48
(11)
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pp. 4097-4102
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2009 ◽
Vol 53
(5)
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pp. 2212-2214
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2006 ◽
Vol 50
(10)
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pp. 3343-3349
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2015 ◽
Vol 10
(4)
◽
pp. 917
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2017 ◽
Vol 10
(4)
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pp. 216
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