Protection against Lipopolysaccharide-Induced Death by Fluoroquinolones
2000 ◽
Vol 44
(11)
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pp. 3169-3173
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Keyword(s):
ABSTRACT Because fluoroquinolones have an immunomodulatory effect on cytokine production by lipopolysaccharide (LPS)-treated human monocytes, we examined the effect of fluoroquinolones on the survival of mice injected with a lethal dose of LPS. Trovafloxacin (100 mg/kg), ciprofloxacin (250 mg/kg), and tosufloxacin (100 mg/kg) protected 75% (P = 0.0001), 25% (P = 0.002), and 50% (P = 0.002), respectively, of mice against death. The fluoroquinolones significantly reduced serum levels of interleukin-6 and tumor necrosis factor alpha in LPS-treated mice. The protective effects of fluoroquinolones in LPS-induced shock in mice may also occur in humans.
1999 ◽
Vol 43
(3)
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pp. 697-698
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1995 ◽
Vol 63
(8)
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pp. 2919-2923
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1993 ◽
Vol 37
(9)
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pp. 1958-1961
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1991 ◽
Vol 261
(4)
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pp. L315-L321
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Keyword(s):
Keyword(s):
1993 ◽
Vol 76
(6)
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pp. 1594-1598