Rv2686c-Rv2687c-Rv2688c, an ABC Fluoroquinolone Efflux Pump in Mycobacterium tuberculosis
2004 ◽
Vol 48
(8)
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pp. 3175-3178
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Keyword(s):
ABSTRACT The Mycobacterium tuberculosis Rv2686c-Rv2687c-Rv2688c operon, encoding an ABC transporter, conferred resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin, and sparfloxacin to Mycobacterium smegmatis. The resistance level decreased in the presence of the efflux pump inhibitors reserpine, carbonyl cyanide m-chlorophenylhydrazone, and verapamil. Energy-dependent efflux of ciprofloxacin from M. smegmatis cells containing the Rv2686c-Rv2687c-Rv2688c operon was observed.
2005 ◽
Vol 49
(11)
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pp. 4775-4777
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2011 ◽
Vol 56
(1)
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pp. 324-331
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2001 ◽
Vol 45
(3)
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pp. 800-804
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2010 ◽
Vol 54
(9)
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pp. 3770-3775
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2016 ◽
Vol 2
(10)
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pp. 714-725
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2017 ◽
Vol 50
(3)
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pp. 491-495
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2016 ◽
Vol 5
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pp. 88-89
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