scholarly journals A Role for Interleukin-6 in Host Defense against Murine Chlamydia trachomatis Infection

1998 ◽  
Vol 66 (9) ◽  
pp. 4564-4567 ◽  
Author(s):  
Dwight M. Williams ◽  
Barry G. Grubbs ◽  
Toni Darville ◽  
Kathleen Kelly ◽  
Roger G. Rank
Keyword(s):  
Chlamydia Trachomatis ◽  
Host Defense ◽  
Lung Tissue ◽  
Specific Antibody ◽  
Knockout Mice ◽  
Interleukin 6 ◽  
Host Response ◽  
Interferon Production ◽  
Chlamydia Trachomatis Infection ◽  
Antibody Levels

ABSTRACT Interleukin-6-deficient (IL-6−/−) knockout mice had significantly increased Chlamydia trachomatis levels in lung tissue and increased mortality compared to B6129F2/J controls early after intranasal infection. Gamma interferon production and chlamydia-specific antibody levels were consistent with a decreased but reversible Th1-like response in IL-6−/− mice. IL-6 is needed for an optimal early host response to this infection.

A Role for Interleukin-6 in Host Defense against Murine Chlamydia trachomatis Infection

1998 ◽  
Vol 66 (9) ◽  
pp. 4564-4567 ◽  
Author(s):  
Dwight M. Williams ◽  
Barry G. Grubbs ◽  
Toni Darville ◽  
Kathleen Kelly ◽  
Roger G. Rank
Keyword(s):  
Chlamydia Trachomatis ◽  
Host Defense ◽  
Interleukin 6 ◽  
Chlamydia Trachomatis Infection

scholarly journals Serum antibodies to surface proteins of Chlamydia trachomatis as candidate biomarkers of disease: Results from the Baltimore Chlamydia Adolescent/Young Adult Reproductive Management (CHARM) cohort.

2021 ◽  
Author(s):  
Patricia X Marques ◽  
Handan Wand ◽  
Melissa Nandy ◽  
Chun Tan ◽  
Huizhong Shou ◽  
...  
Keyword(s):  
Young Adult ◽  
Chlamydia Trachomatis ◽  
Specific Antibody ◽  
Statistical Significance ◽  
Serum Antibody ◽  
Surface Proteins ◽  
Indirect Measure ◽  
Reproductive Management ◽  
Immune Biomarkers ◽  
Antibody Levels

Background: We previously observed that the nine-member family of autotransported polymorphic membrane proteins (Pmps) of Chlamydia trachomatis is variably expressed in cell culture. Additionally, C. trachomatis-infected patients display variable Pmp-specific serum antibody profiles indirectly suggesting expression of unique Pmp profiles is an adaptive response to host-specific stimuli during infection. Here, we propose that the host response to Pmps and other outer surface proteins may correlate with disease severity. Methods: This study tests this hypothesis using an ELISA that measures serum IgG antibodies specific for the nine C. trachomatis Pmp subtypes and four immunodominant antigens (MOMP, OmcB, GroEL, ClpP) in 265 participants of the Chlamydia Adolescent/Young Adult Reproductive Management (CHARM) cohort. Results: More C. trachomatis-infected females displayed high Pmp-specific antibody levels (cut-off Indexes) than males (35.9-40.7% of females vs. 24.2-30.0% of males), with statistical significance for PmpC, F and H (P<0.05). Differences in Pmp-specific antibody profiles were not observed between C. trachomatis-infected females with a clinical diagnosis of pelvic inflammatory disease (PID) and those without. However, a statistically significant association between high levels of OmcB-specific antibody and a PID diagnosis (P<0.05) was observed. Conclusions: Using antibody levels as an indirect measure of antigen expression, our results suggest that gender- and/or site-specific (cervix in females vs. urethra in males) stimuli control pmp expression in infected patients. They also support the possible existence of immune biomarkers of chlamydial infection associated with disease and underline the need for high resolution screening in human serum.

scholarly journals Urethral Cytokine and Immune Responses inChlamydia trachomatis-Infected Males

2001 ◽  
Vol 69 (11) ◽  
pp. 7178-7181 ◽  
Author(s):  
Mitchell S. Pate ◽  
Spencer R. Hedges ◽  
Don A. Sibley ◽  
Michael W. Russell ◽  
Edward W. Hook ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Immune Responses ◽  
Immunosorbent Assay ◽  
Specific Antibody ◽  
Enzyme Linked Immunosorbent Assay ◽  
Igg Antibodies ◽  
Nongonococcal Urethritis ◽  
Antibody Levels ◽  
Cellular Components ◽  
Total Immunoglobulin

ABSTRACT Penile urethral swabs collected from PCR-confirmed Chlamydia trachomatis-infected, C. trachomatis-uninfected, and non-C. trachomatis-infected, nongonococcal urethritis-infected males were analyzed for cytokine, total immunoglobulin (Ig), and specific antibody levels by enzyme-linked immunosorbent assay. Differential cellular components of the swab transport medium were also enumerated for the same groups. Although low, the levels of C. trachomatis-specific IgA and IgG antibodies and interleukin 8 cytokine were significantly higher inC. trachomatis-infected individuals. There were no significant differences in the levels of seven additional cytokines evaluated.

scholarly journals P3.026 Low Prevalence of Chlamydia Trachomatis Infection: Fact or Missed Diagnosis?

2013 ◽  
Vol 89 (Suppl 1) ◽  
pp. A156.1-A156
Author(s):  
T Bharara ◽  
D Rawat ◽  
P Bhalla ◽  
V K Garg ◽  
K Sardana ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Chlamydia Trachomatis Infection ◽  
Missed Diagnosis ◽  
Low Prevalence

scholarly journals Differential Regulation of Inflammatory Cytokine Secretion by Human Dendritic Cells upon Chlamydia trachomatis Infection

2004 ◽  
Vol 72 (12) ◽  
pp. 7231-7239 ◽  
Author(s):  
Ana Gervassi ◽  
Mark R. Alderson ◽  
Robert Suchland ◽  
Jean François Maisonneuve ◽  
Kenneth H. Grabstein ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Chlamydia Trachomatis ◽  
Wide Spectrum ◽  
Cytokine Secretion ◽  
Host Cells ◽  
Microbial Pathogens ◽  
Potential Contribution ◽  
Necrosis Factor Alpha ◽  
Chlamydia Trachomatis Infection ◽  
Tnf Α

ABSTRACT Chlamydia trachomatis is an obligate intracellular gram-negative bacterium responsible for a wide spectrum of diseases in humans. Both genital and ocular C. trachomatis infections are associated with tissue inflammation and pathology. Dendritic cells (DC) play an important role in both innate and adaptive immune responses to microbial pathogens and are a source of inflammatory cytokines. To determine the potential contribution of DC to the inflammatory process, human DC were infected with C. trachomatis serovar E or L2. Both C. trachomatis serovars were found to infect and replicate in DC. Upon infection, DC up-regulated the expression of costimulatory (B7-1) and cell adhesion (ICAM-1) molecules. Furthermore, chlamydial infection induced the secretion of interleukin-1β (IL-1β), IL-6, IL-8, IL-12p70, IL-18, and tumor necrosis factor alpha (TNF-α). The mechanisms involved in Chlamydia-induced IL-1β and IL-18 secretion differed from those of the other cytokines. Chlamydia-induced IL-1β and IL-18 secretion required infection with viable bacteria and was associated with the Chlamydia-induced activation of caspase-1 in infected host cells. In contrast, TNF-α and IL-6 secretion did not require that the Chlamydia be viable, suggesting that there are at least two mechanisms involved in the Chlamydia-induced cytokine secretion in DC. Interestingly, an antibody to Toll-like receptor 4 inhibited Chlamydia-induced IL-1β, IL-6, and TNF-α secretion. The data herein demonstrate that DC can be infected by human C. trachomatis serovars and that chlamydial components regulate the secretion of various cytokines in DC. Collectively, these data suggest that DC play a role in the inflammatory processes caused by chlamydial infections.

Scrotal mass with fever and generalized lymphadenopathy in a young man secondary to Chlamydia trachomatis infection

2005 ◽  
Vol 51 (3) ◽  
pp. e107-e108 ◽  
Author(s):  
N.E. Jenkins ◽  
L. Radcliffe ◽  
Mike Beadsworth ◽  
H. Mallinson ◽  
Fred Nye ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Scrotal Mass ◽  
Chlamydia Trachomatis Infection ◽  
Generalized Lymphadenopathy
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