scholarly journals Hydrostatic Pressure Effects on Escherichia coli: Site of Inhibition of Protein Synthesis

1972 ◽  
Vol 109 (2) ◽  
pp. 945-948 ◽  
Author(s):  
J. R. Schwarz ◽  
J. V. Landau
Keyword(s):  
Escherichia Coli ◽  
Protein Synthesis ◽  
Hydrostatic Pressure ◽  
Pressure Effects ◽  
Inhibition Of Protein Synthesis

Hydrostatic pressure effects on several stages of protein synthesis in Escherichia coli

1974 ◽  
Vol 20 (3) ◽  
pp. 359-365 ◽  
Author(s):  
Michael J. Hardon ◽  
Lawrence J. Albright
Keyword(s):  
Escherichia Coli ◽  
Protein Synthesis ◽  
Hydrostatic Pressure ◽  
Specific Activity ◽  
Trna Synthetase ◽  
Pressure Effects ◽  
Acid Activation ◽  
Amino Acid Activation ◽  
The Stability ◽  
Translational Ambiguity

Hydrostatic pressure has been shown to inhibit protein synthesis in Escherichia coli by inhibiting amino acid activation and polypeptide synthesis in cell-free systems. Pressure may decrease translational ambiguity by suppressing any non-specific activity of phenylalanyl-tRNA synthetase and by preferentially decreasing the stability of leucyl-tRNA.

scholarly journals Lethal Action of Quinolones against a Temperature-Sensitive dnaB Replication Mutant of Escherichia coli

2006 ◽  
Vol 50 (1) ◽  
pp. 362-364 ◽  
Author(s):  
Xilin Zhao ◽  
Muhammad Malik ◽  
Nymph Chan ◽  
Alex Drlica-Wagner ◽  
Jian-Ying Wang ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Protein Synthesis ◽  
Dna Replication ◽  
Nalidixic Acid ◽  
Temperature Sensitive ◽  
Wild Type ◽  
Lethal Action ◽  
Inhibition Of Protein Synthesis

ABSTRACT Inhibition of DNA replication in an Escherichia coli dnaB-22 mutant failed to block quinolone-mediated lethality. Inhibition of protein synthesis by chloramphenicol inhibited nalidixic acid lethality and, to a lesser extent, ciprofloxacin lethality in both dnaB-22 and wild-type cells. Thus, major features of quinolone-mediated lethality do not depend on ongoing replication.

Cysteine homeostasis under inhibition of protein synthesis in Escherichia coli cells

Amino Acids ◽  
2019 ◽  
Vol 51 (10-12) ◽  
pp. 1577-1592 ◽  
Author(s):  
Galina V. Smirnova ◽  
Aleksey V. Tyulenev ◽  
Kseniya V. Bezmaternykh ◽  
Nadezda G. Muzyka ◽  
Vadim Y. Ushakov ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Protein Synthesis ◽  
Escherichia Coli Cells ◽  
Inhibition Of Protein Synthesis

scholarly journals Hydrostatic Pressure Effects on Protein Synthesis

1972 ◽  
Vol 12 (10) ◽  
pp. 1235-1250 ◽  
Author(s):  
C.E. Hildebrand ◽  
E.C. Pollard
Keyword(s):  
Protein Synthesis ◽  
Hydrostatic Pressure ◽  
Pressure Effects

scholarly journals The action of streptomycin in a mutant of Escherichia coli with increased sensitivity to the antibiotic

1970 ◽  
Vol 118 (4) ◽  
pp. 659-666 ◽  
Author(s):  
G. Turnock
Keyword(s):  
Escherichia Coli ◽  
Protein Synthesis ◽  
Normal Cell ◽  
Permeability Barrier ◽  
Bactericidal Action ◽  
Site Of Action ◽  
Inhibition Of Protein Synthesis ◽  
Increased Sensitivity ◽  
Lag Period

A mutant of Escherichia coli with increased sensitivity to streptomycin has been studied. This strain differed from a normal strs strain in that streptomycin produced inhibition of protein synthesis and loss of viability with almost no lag period. Chloramphenicol protected a normal strs strain but not the mutant against the bactericidal action of streptomycin. The results obtained support the idea that access of streptomycin to its site of action in a normal cell is restricted, and that this restriction, which is much less effective in the mutant, probably involves a permeability barrier. Comparison of the inhibition of protein synthesis by streptomycin with concomitant changes in the distribution of polyribosomes in both strains suggested that the antibiotic can directly inhibit the translation of mRNA.

Analysis of hydrostatic pressure effects on transcription in Escherichia coli by DNA microarray procedure

Extremophiles ◽  
2004 ◽  
Vol 9 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Akihiro Ishii ◽  
Taku Oshima ◽  
Takako Sato ◽  
Kaoru Nakasone ◽  
Hirotada Mori ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Hydrostatic Pressure ◽  
Dna Microarray ◽  
Pressure Effects
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