scholarly journals Factors Influencing the Sensitivity and Specificity of Conventional Sequencing in Human Immunodeficiency Virus Type 1 Tropism Testing

2012 ◽  
Vol 51 (2) ◽  
pp. 444-451 ◽  
Author(s):  
D. J. H. F. Knapp ◽  
R. A. McGovern ◽  
W. Dong ◽  
A. F. Y. Poon ◽  
L. C. Swenson ◽  
...  
2000 ◽  
Vol 7 (4) ◽  
pp. 698-699 ◽  
Author(s):  
Susan Phillips ◽  
Timothy C. Granade ◽  
Chou-Pong Pau ◽  
Debra Candal ◽  
Dale J. Hu ◽  
...  

ABSTRACT We evaluated six rapid tests for their sensitivity and specificity in diagnosing human immunodeficiency virus type 1 (HIV-1) infection using 241 specimens (172 HIV-1 positive, 69 HIV-1 negative) representing different HIV-1 subtypes (A [n = 40], B [n = 47], C [n = 28], E [n = 42], and F [n = 7]). HIVCHEK, Multispot, RTD and SeroStrip were 100% sensitive and specific. Capillus failed to identify two of eight subtype C specimens (overall sensitivity of 98.85%), while the SUDS test (the only test approved by the Food and Drug Administration) gave false-positive results for 5 of 69 seronegative specimens (specificity of 93.24%). Our results suggest that although rapid tests perform well in general, it may be prudent to evaluate a rapid test for sensitivity and specificity in a local population prior to its widespread use.


1996 ◽  
Vol 174 (1) ◽  
pp. 26-33 ◽  
Author(s):  
M. P. Busch ◽  
E. A. Operskalski ◽  
J. W. Mosley ◽  
T.- H. Lee ◽  
D. Henrard ◽  
...  

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