The NS1 Protein of Influenza A Virus Blocks RIG-I-Mediated Activation of the Noncanonical NF-κB Pathway and p52/RelB-Dependent Gene Expression in Lung Epithelial Cells
Keyword(s):
Influenza A virus (IAV) infection of epithelial cells activates NF-κB transcription factors via the canonical NF-κB signaling pathway, which modulates both the antiviral immune response and viral replication. Since almost nothing is known so far about a function of noncanonical NF-κB signaling after IAV infection, we tested infected cells for activation of p52 and RelB. We show that the viral NS1 protein strongly inhibits RIG-I-mediated noncanonical NF-κB activation and expression of the noncanonical target gene CCL19.
2016 ◽
Vol 8
(17)
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pp. 2017-2031
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Keyword(s):
2019 ◽
Vol 61
(3)
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pp. 395-398
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Keyword(s):
2012 ◽
Vol 16
(10)
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pp. 2539-2546
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Keyword(s):
2016 ◽