scholarly journals Chromosomal mapping of murine c-fes and c-src genes.

1984 ◽  
Vol 4 (5) ◽  
pp. 978-981 ◽  
Author(s):  
C Blatt ◽  
M E Harper ◽  
G Franchini ◽  
M N Nesbitt ◽  
M I Simon
Keyword(s):  
Kinase Activity ◽  
Restriction Site ◽  
Mouse Genome ◽  
Inbred Strains ◽  
Chromosomal Mapping ◽  
Chromosome 2 ◽  
Distal Half ◽  
Viral Oncogenes ◽  
Tyrosine Specific Kinase ◽  
Restriction Site Polymorphisms

The murine homologs of two viral oncogenes associated with tyrosine-specific kinase activity have been assigned to different loci in the mouse genome. The segregation of restriction site polymorphisms, as detected by probes that are specific for endogenous c-fes and c-src sequences, was followed in the DNA of recombinant inbred strains. The c-fes gene was mapped to the proximal portion of chromosome 7, very close to the Gpi-1 locus, whereas c-src was linked to the Psp locus on the distal half of chromosome 2.

scholarly journals Chromosomal mapping of murine c-fes and c-src genes

1984 ◽  
Vol 4 (5) ◽  
pp. 978-981
Author(s):  
C Blatt ◽  
M E Harper ◽  
G Franchini ◽  
M N Nesbitt ◽  
M I Simon
Keyword(s):  
Kinase Activity ◽  
Restriction Site ◽  
Mouse Genome ◽  
Inbred Strains ◽  
Chromosomal Mapping ◽  
Chromosome 2 ◽  
Distal Half ◽  
Viral Oncogenes ◽  
Tyrosine Specific Kinase ◽  
Restriction Site Polymorphisms

The murine homologs of two viral oncogenes associated with tyrosine-specific kinase activity have been assigned to different loci in the mouse genome. The segregation of restriction site polymorphisms, as detected by probes that are specific for endogenous c-fes and c-src sequences, was followed in the DNA of recombinant inbred strains. The c-fes gene was mapped to the proximal portion of chromosome 7, very close to the Gpi-1 locus, whereas c-src was linked to the Psp locus on the distal half of chromosome 2.

scholarly journals Species ofBorreliadistinguished by restriction site polymorphisms in 16S rRNA genes

1993 ◽  
Vol 111 (2-3) ◽  
pp. 239-243 ◽  
Author(s):  
David Ralph ◽  
Daniele Postic ◽  
Guy Baranton ◽  
Charles Pretzman ◽  
Michael McClelland
Keyword(s):  
16S Rrna ◽  
Restriction Site ◽  
16S Rrna Genes ◽  
Rrna Genes ◽  
Restriction Site Polymorphisms

Structural basis for restriction-site polymorphism at the albumin locus in inbred strains of rats

1985 ◽  
Vol 23 (3-4) ◽  
pp. 257-266 ◽  
Author(s):  
Andras Gal ◽  
Jean-Louis Nahon ◽  
Gerard Lucotte ◽  
Tamas Erdos ◽  
Jos� M. Sala-Trepat
Keyword(s):  
Restriction Site ◽  
Inbred Strains ◽  
Structural Basis ◽  
Restriction Site Polymorphism

Assignment of two mitochondrially synthesized polypeptides to human mitochondrial DNA and their use in the study of intracellular mitochondrial interaction

1982 ◽  
Vol 2 (1) ◽  
pp. 30-41
Author(s):  
N A Oliver ◽  
D C Wallace
Keyword(s):  
Mitochondrial Dna ◽  
Restriction Site ◽  
Mitochondrial Protein ◽  
Mitochondrial Protein Synthesis ◽  
Human Mitochondrial Dna ◽  
Ht1080 Cells ◽  
Mitochondrial Dnas ◽  
A Cell ◽  
Dna Restriction ◽  
Restriction Site Polymorphisms

Two mitochondrially synthesized marker polypeptides, MV-1 and MV-2, were found in human HeLa and HT1080 cells. These were assigned to the mitochondrial DNA in HeLa-HT1080 cybrids and hybrids by demonstrating their linkage to cytoplasmic genetic markers. These markers include mitochondrial DNA restriction site polymorphisms and resistance to chloramphenicol, an inhibitor of mitochondrial protein synthesis. In the absence of chloramphenicol, the expression of MV-1 and MV-2 in cybrids and hybrids was found to be directly proportional to the ratio of the parental mitochondrial DNAs. In the presence of chloramphenicol, the marker polypeptide linked to the chloramphenicol-sensitive mitochondrial DNA continued to be expressed. This demonstrated that resistant and sensitive mitochondrial DNAs can cooperate within a cell for gene expression and that the CAP-resistant allele was dominant or codominant to sensitive. Such cooperation suggests that mitochondrial DNAs can be exchanged between mitochondria.

scholarly journals Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains

2017 ◽  
Vol 114 (34) ◽  
pp. 9158-9163 ◽  
Author(s):  
Steven Timmermans ◽  
Marc Van Montagu ◽  
Claude Libert
Keyword(s):  
Mouse Genome ◽  
Inbred Strains ◽  
Nucleotide Polymorphisms ◽  
Genome Sequences ◽  
Single Nucleotide ◽  
Protein Coding ◽  
Stop Codons ◽  
Protein Coding Genes ◽  
Sequence Variations ◽  
Genetic Background Effects

Mouse inbred strains remain essential in science. We have analyzed the publicly available genome sequences of 36 popular inbred strains and provide lists for each strain of protein-coding genes that acquired sequence variations that cause premature STOP codons, loss of STOP codons and single nucleotide polymorphisms, and short in-frame insertions and deletions. Our data give an overview of predicted defective proteins, including predicted impact scores, of all these strains compared with the reference mouse genome of C57BL/6J. These data can also be retrieved via a searchable website (mousepost.be) and allow a global, better interpretation of genetic background effects and a source of naturally defective alleles in these 36 sequenced classical and high-priority mouse inbred strains.

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