CO-OCCURRING TRACE ELEMENTS (CTES) OF POTENTIAL HUMAN HEALTH CONCERN IN ARSENIC CONTAMINATED AQUIFERS IN THE BENGAL BASIN

2020 ◽  
Author(s):  
Harshad Vijay Kulkarni ◽  
◽  
Michael Vega ◽  
Karen Johannesson ◽  
Robert Taylor ◽  
...  
Author(s):  
Zunwei Chen ◽  
Suji Jang ◽  
James M. Kaihatu ◽  
Yi-Hui Zhou ◽  
Fred A. Wright ◽  
...  

Natural and anthropogenic disasters may be associated with redistribution of chemical contaminants in the environment; however, current methods for assessing hazards and risks of complex mixtures are not suitable for disaster response. This study investigated the suitability of in vitro toxicity testing methods as a rapid means of identifying areas of potential human health concern. We used sediment samples (n = 46) from Galveston Bay and the Houston Ship Channel (GB/HSC) areas after hurricane Harvey, a disaster event that led to broad redistribution of chemically-contaminated sediments, including deposition of the sediment on shore due to flooding. Samples were extracted with cyclohexane and dimethyl sulfoxide and screened in a compendium of human primary or induced pluripotent stem cell (iPSC)-derived cell lines from different tissues (hepatocytes, neuronal, cardiomyocytes, and endothelial) to test for concentration-dependent effects on various functional and cytotoxicity phenotypes (n = 34). Bioactivity data were used to map areas of potential concern and the results compared to the data on concentrations of polycyclic aromatic hydrocarbons (PAHs) in the same samples. We found that setting remediation goals based on reducing bioactivity is protective of both “known” risks associated with PAHs and “unknown” risks associated with bioactivity, but the converse was not true for remediation based on PAH risks alone. Overall, we found that in vitro bioactivity can be used as a comprehensive indicator of potential hazards and is an example of a new approach method (NAM) to inform risk management decisions on site cleanup.


2020 ◽  
Vol 122 ◽  
pp. 104709
Author(s):  
Michael A. Vega ◽  
Harshad V. Kulkarni ◽  
Karen H. Johannesson ◽  
Robert J. Taylor ◽  
Saugata Datta

2021 ◽  
Vol 10 (13) ◽  
pp. 2903
Author(s):  
Jiezhong Chen ◽  
Luis Vitetta

The gut microbiota is well known to exert multiple benefits on human health including protection from disease causing pathobiont microbes. It has been recognized that healthy intestinal microbiota is of great importance in the pathogenesis of COVID-19. Gut dysbiosis caused by various reasons is associated with severe COVID-19. Therefore, the modulation of gut microbiota and supplementation of commensal bacterial metabolites could reduce the severity of COVID-19. Many approaches have been studied to improve gut microbiota in COVID-19 including probiotics, bacterial metabolites, and prebiotics, as well as nutraceuticals and trace elements. So far, 19 clinical trials for testing the efficacy of probiotics and synbiotics in COVID-19 prevention and treatment are ongoing. In this narrative review, we summarize the effects of various approaches on the prevention and treatment of COVID-19 and discuss associated mechanisms.


Water ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 783
Author(s):  
Feifei Chen ◽  
Leihua Yao ◽  
Gang Mei ◽  
Yinsheng Shang ◽  
Fansheng Xiong ◽  
...  

Groundwater is a valuable water source for drinking and irrigation purposes in semiarid regions. Groundwater pollution may affect human health if it is not pretreated and provided for human use. This study investigated the hydrochemical characteristics driving groundwater quality for drinking and irrigation purposes and potential human health risks in the Xinzhou Basin, Shanxi Province, North China. More specifically, we first investigated hydrochemical characteristics using a descriptive statistical analysis method. We then classified the hydrochemical types and analyzed the evolution mechanisms of groundwater using Piper and Gibbs diagrams. Finally, we appraised the groundwater quality for drinking and irrigation purposes using the entropy water quality index (EWQI). We assessed the associated human health risks for different age and sex groups through drinking intake and dermal contact pathways. Overall, we found that (1) Ca-HCO3 and Ca·Mg-HCO3 were the dominant hydrochemical types and were mainly governed by rock weathering and water–rock interactions. (2) Based on the EWQI classifications, 67.74% of the groundwater samples were classified as medium quality and acceptable for drinking purpose. According to the values of sodium adsorption ratio (SAR), residual sodium carbonate (RSC) and soluble sodium percentage (%Na), 90.32% of the samples were suitable for irrigation, while the remaining samples were unfit for irrigation because of the high salinity in the groundwater. (3) Some contaminants in the groundwater, such as NO3−, NO2− and F−, exceeded the standard limits and may cause potential risks to human health. Our work presented in this paper could establish reasonable management strategies for sustainable groundwater quality protection to protect public health.


2021 ◽  
Vol 97 ◽  
pp. 103754
Author(s):  
Naghmeh Soltani ◽  
Michel Marengo ◽  
Behnam Keshavarzi ◽  
Farid Moore ◽  
Peter S. Hooda ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document