Role of FOXO transcription factor in radiation adaptive response and hormesis in Drosophila melanogaster

Specific neuropeptides regulate in arthropods the shedding of the old cuticle (ecdysis) followed by maturation of the new cuticle. In Drosophila melanogaster , the last ecdysis occurs at eclosion from the pupal case, with a post-eclosion behavioural sequence that leads to wing extension, cuticle stretching and tanning. These events are highly stereotyped and are controlled by a subset of crustacean cardioactive peptide (CCAP) neurons through the expression of the neuropeptide Bursicon (Burs). We have studied the role of the transcription factor Odd-paired (Opa) during the post-eclosion period. We report that opa is expressed in the CCAP neurons of the central nervous system during various steps of the ecdysis process and in peripheral CCAP neurons innerving the larval muscles involved in adult ecdysis. We show that its downregulation alters Burs expression in the CCAP neurons. Ectopic expression of Opa, or the vertebrate homologue Zic2 , in the CCAP neurons also affects Burs expression, indicating an evolutionary functional conservation. Finally, our results show that, independently of its role in Burs regulation, Opa prevents death of CCAP neurons during larval development.

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Abstract 2471: Role of FOXO transcription factor dynamics in determining cell fates following EGFR inhibition

10.1158/1538-7445.am2020-2471 ◽

2020 ◽

Author(s):

Julie M. Huynh ◽

Kayenat S. Aryeh ◽

Lisa Shanks ◽

Andrew L. Paek

Keyword(s):

Transcription Factor ◽

Cell Fates ◽

Foxo Transcription Factor ◽

Egfr Inhibition

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Impacts of a new transcription factor family

The Journal of Cell Biology ◽

10.1083/jcb.200406097 ◽

2004 ◽

Vol 166 (6) ◽

pp. 765-768 ◽

Cited By ~ 20

Author(s):

Said Hashemolhosseini ◽

Michael Wegner

Keyword(s):

Transcription Factor ◽

Drosophila Melanogaster ◽

Dna Binding ◽

Family Member ◽

Parathyroid Gland ◽

Dna Binding Domain ◽

Transcription Factor Family ◽

Master Regulators ◽

Zinc Cations

GCM proteins constitute a small transcription factor family with a DNA-binding domain exhibiting a novel fold composed of two subdomains rigidly held together by coordination of one of two structural zinc cations. In all known cases, GCM proteins exert the role of master regulators: the prototypical family member determines gliogenesis in Drosophila melanogaster, whereas mammalian GCM proteins orchestrate divergent aspects of development and physiology in placenta, kidney, thymus, and parathyroid gland. Recent data point to an involvement of GCM proteins in different pathological contexts, such as preeclampsia, hyper- or hypoparathyroidism, and parathyroid gland tumors.

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Trajectory Shifts in Interdisciplinary Research of the Aryl Hydrocarbon Receptor—A Personal Perspective on Thymus and Skin

International Journal of Molecular Sciences ◽

10.3390/ijms22041844 ◽

2021 ◽

Vol 22 (4) ◽

pp. 1844

Author(s):

Charlotte Esser

Keyword(s):

Transcription Factor ◽

Immune System ◽

Environmental Pollution ◽

Aryl Hydrocarbon Receptor ◽

Interdisciplinary Research ◽

Adaptive Response ◽

Personal Perspective ◽

Aryl Hydrocarbon

Identifying historical trajectories is a useful exercise in research, as it helps clarify important, perhaps even “paradigmatic”, shifts in thinking and moving forward in science. In this review, the development of research regarding the role of the transcription factor “aryl hydrocarbon receptor” (AHR) as a mediator of the toxicity of environmental pollution towards a link between the environment and a healthy adaptive response of the immune system and the skin is discussed. From this fascinating development, the opportunities for targeting the AHR in the therapy of many diseases become clear.

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The potential role of FoxO transcription factor during postembryonic periods in the silkworm, Bombyx mori (Lepidoptera: Bombycidae)

European Journal of Entomology ◽

10.14411/eje.2012.042 ◽

2012 ◽

Vol 109 (3) ◽

pp. 325-330

Author(s):

Jin Kim HEE ◽

Jae-Sun CHOI ◽

Mi Young KIM ◽

Hwa Young SONG ◽

Bong Lee HEE

Keyword(s):

Transcription Factor ◽

Bombyx Mori ◽

Potential Role ◽

Foxo Transcription Factor ◽

Silkworm Bombyx Mori

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Hif-1α regulates differentiation of limb bud mesenchyme and joint development

The Journal of Cell Biology ◽

10.1083/jcb.200612023 ◽

2007 ◽

Vol 177 (3) ◽

pp. 451-464 ◽

Cited By ~ 133

Author(s):

Sylvain Provot ◽

Dawn Zinyk ◽

Yasemin Gunes ◽

Richa Kathri ◽

Quynh Le ◽

...

Keyword(s):

Transcription Factor ◽

Fetal Development ◽

Adaptive Response ◽

Conditional Knockout ◽

Limb Bud ◽

Low Oxygen ◽

Joint Development ◽

Low Oxygen Tension ◽

Development And Differentiation

Recent evidence suggests that low oxygen tension (hypoxia) may control fetal development and differentiation. A crucial mediator of the adaptive response of cells to hypoxia is the transcription factor Hif-1α. In this study, we provide evidence that mesenchymal condensations that give origin to endochondral bones are hypoxic during fetal development, and we demonstrate that Hif-1α is expressed and transcriptionally active in limb bud mesenchyme and in mesenchymal condensations. To investigate the role of Hif-1α in mesenchymal condensations and in early chondrogenesis, we conditionally inactivated Hif-1α in limb bud mesenchyme using a Prx1 promoter-driven Cre transgenic mouse. Conditional knockout of Hif-1α in limb bud mesenchyme does not impair mesenchyme condensation, but alters the formation of the cartilaginous primordia. Late hypertrophic differentiation is also affected as a result of the delay in early chondrogenesis. In addition, mutant mice show a striking impairment of joint development. Our study demonstrates a crucial, and previously unrecognized, role of Hif-1α in early chondrogenesis and joint formation.

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Mutations of zeste that mediate transvection are recessive enhancers of position-effect variegation in Drosophila melanogaster.

Genetics ◽

10.1093/genetics/141.1.245 ◽

1995 ◽

Vol 141 (1) ◽

pp. 245-253 ◽

Cited By ~ 2

Author(s):

B H Judd

Keyword(s):

Transcription Factor ◽

Drosophila Melanogaster ◽

Transposable Elements ◽

Chromosomal Rearrangement ◽

Position Effect ◽

Dna Binding Protein ◽

Position Effect Variegation ◽

Effect Variegation ◽

Null State

Abstract Evidence is presented demonstrating that mutations of zeste, particularly the null state, are strong recessive enhancers of position-effect variegation (PEV) for the white, roughest and Notch loci. The zeste locus encodes a DNA-binding protein that acts as a transcription factor and mediates transvection phenomena at several loci. Its involvement with these seemingly diverse phenomena suggests that the normal zeste product functions in the decondensation of chromatin. A model is presented proposing that zeste is important for opening and stabilizing domains of chromatin, a step in gene determination and the establishment of cell memory. It postulates that chromatin domains that have been structurally modified by chromosomal rearrangement or by insertion of transposable elements are particularly sensitive to the absence or modification of the zeste protein. Such a view unifies the role of zeste in transcription, transvection and PEV.

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