Development of novel formulations for photodynamic therapy on the basis of amphiphilic polymers and porphyrin photosensitizers. Pluronic influence on photocatalytic activity of porphyrins

Laser Physics ◽  
2009 ◽  
Vol 19 (4) ◽  
pp. 817-824 ◽  
Author(s):  
A. B. Solovieva ◽  
N. S. Melik-Nubarov ◽  
T. M. Zhiyentayev ◽  
P. I. Tolstih ◽  
I. I. Kuleshov ◽  
...  
Keyword(s):  
Photocatalytic Activity ◽  
Photodynamic Therapy ◽  
Amphiphilic Polymers ◽  
Porphyrin Photosensitizers

The influence of amphiphilic polymers on the photocatalytic activity of water-soluble porphyrin photosensitizers

2011 ◽  
Vol 85 (5) ◽  
pp. 871-875 ◽  
Author(s):  
Yu. A. Gorokh ◽  
N. A. Aksenova ◽  
A. B. Solov’eva ◽  
V. A. Ol’shevskaya ◽  
A. V. Zaitsev ◽  
...  
Keyword(s):  
Photocatalytic Activity ◽  
Amphiphilic Polymers ◽  
Water Soluble ◽  
Porphyrin Photosensitizers ◽  
Water Soluble Porphyrin

Highly Luminescent, Stable, and Red-Emitting CsMgxPb1–xI3 Quantum Dots for Dual-Modal Imaging-Guided Photodynamic Therapy and Photocatalytic Activity

2021 ◽  
Author(s):  
Girum Getachew ◽  
Chiranjeevi Korupalli ◽  
Akash S. Rasal ◽  
Worku Batu Dirersa ◽  
Mochamad Z. Fahmi ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Photocatalytic Activity ◽  
Photodynamic Therapy

Amphiphilic polymers in photodynamic therapy

2012 ◽  
Vol 6 (3) ◽  
pp. 433-440 ◽  
Author(s):  
A. B. Solov’eva ◽  
N. A. Aksenova ◽  
N. N. Glagolev ◽  
N. S. Melik-Nubarov ◽  
A. V. Ivanov ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Amphiphilic Polymers

Prospects of radical-interacting porphyrin photosensitizers and their possible use in photodynamic therapy

1994 ◽  
Author(s):  
Dezso Gal ◽  
T Shuliakovskaya ◽  
Tamas Vidoczy ◽  
Saleh Elzemzam ◽  
Gabor Vasvari ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Porphyrin Photosensitizers

Physicochemical properties of potential porphyrin photosensitizers for photodynamic therapy

2015 ◽  
Vol 146 ◽  
pp. 249-254 ◽  
Author(s):  
Marta Kempa ◽  
Patrycja Kozub ◽  
Joseph Kimball ◽  
Marcin Rojkiewicz ◽  
Piotr Kuś ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Physicochemical Properties ◽  
Porphyrin Photosensitizers

scholarly journals Bactericidal effect of photodynamic therapy against methicillin-resistant Staphylococcus aureus strain with the use of various porphyrin photosensitizers.

2007 ◽  
Vol 54 (3) ◽  
pp. 665-670 ◽  
Author(s):  
Mariusz Grinholc ◽  
Bozena Szramka ◽  
Katarzyna Olender ◽  
Alfreda Graczyk
Keyword(s):  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Bactericidal Effect ◽  
Aureus Strain ◽  
Methicillin Resistant ◽  
Essential Change ◽  
Log10 Unit ◽  
Porphyrin Photosensitizers ◽  
Unit Reduction

Photodynamic therapy (PDT) is based on photosensitizers activated by light of appropriate wavelength. Their activation leads to generation of singlet oxygen and free radicals responsible for the cytotoxic effect. The aim of this project was to compare the bactericidal effect of PDT using different porphyrin photosensitizers against a methicillin-resistant Staphylococcus aureus strain. Exogenous sensitizers (protoporphyrin IX and newly synthesized derivative, protoporphyrin diarginate) induced a 3 log10-unit reduction in bacterial viable counts. With the use of endogenous, ALA-induced porphyrins, a 1.6 log10-unit reduction was obtained. The sensitizers tested executed their antibacterial activity with no essential change in the antibiotic resistance pattern of the studied strain.

scholarly journals Effect of Chitosan on the Activity of Water-Soluble and Hydrophobic Porphyrin Photosensitizers Solubilized by Amphiphilic Polymers

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1007
Author(s):  
Valeriya V. Kardumyan ◽  
Nadejda A. Aksenova ◽  
Victoria A. Timofeeva ◽  
Alexey V. Krivandin ◽  
Olga V. Shatalova ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
Amphiphilic Polymers ◽  
Model Reaction ◽  
Amphiphilic Polymer ◽  
Water Soluble ◽  
Pluronic F127 ◽  
Polymer Systems ◽  
Photo Oxidation ◽  
Porphyrin Photosensitizers ◽  
Trisodium Salt

In this work, we studied the photocatalytic activity of photosensitizers (PSs) of various natures solubilized with polyvinylpyrrolidone (PVP) and ternary block copolymer ethylene and propylene oxide Pluronic F127 (F127) in a model reaction of tryptophan photo-oxidation in water in the presence of chitosan (CT). Water-soluble compounds (dimegin and trisodium salt of chlorin e6 (Ce6)) and hydrophobic porphyrins (tetraphenylporphyrin (TPP) and its fluorine derivative (TPPF20)) were used as PSs. It was shown that the use of chitosan (Mw ~100 kDa) makes it possible to obtain a system whose activity is comparable to that of the photosensitizer-amphiphilic polymer systems. Thus, the previously observed drop in the photosensitizing activity of PS in the presence of a polysaccharide and amphiphilic polymers (AP) was absent in this case. At the same time, chitosan had practically no inhibitory effect on hydrophobic porphyrins solubilized by Pluronic F127.

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