Matricide in Caenorhabditis elegans as an example of programmed death of an animal organism: The role of mitochondrial oxidative stress

2011 ◽  
Vol 37 (5) ◽  
pp. 634-639 ◽  
Author(s):  
N. B. Pestov ◽  
M. I. Shakhparonov ◽  
T. V. Korneenko
Keyword(s):  
Oxidative Stress ◽  
Caenorhabditis Elegans ◽  
Mitochondrial Oxidative Stress ◽  
Animal Organism ◽  
Programmed Death

scholarly journals Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans

2018 ◽  
Author(s):  
Shaarika Sarasija ◽  
Kenneth R. Norman
Keyword(s):  
Oxidative Stress ◽  
Caenorhabditis Elegans ◽  
Global Health ◽  
Mitochondrial Function ◽  
Therapeutic Strategies ◽  
Calcium Dysregulation ◽  
Mitochondrial Oxidative Stress ◽  
Health Crisis ◽  
Genes Encoding

Neurodegenerative diseases like Alzheimer’s disease (AD) are poised to become a global health crisis, and therefore understanding the mechanisms underlying the pathogenesis is critical for the development of therapeutic strategies. Mutations in genes encoding presenilin occur in most familial Alzheimer’s disease but the role of PSEN in AD is not fully understood. In this review, the potential modes of pathogenesis of AD are discussed, focusing on calcium homeostasis and mitochondrial function. Moreover, research using Caenorhabditis elegans to explore the effects of calcium dysregulation due to presenilin mutations on mitochondrial function, oxidative stress and neurodegeneration is explored.

scholarly journals Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans

Antioxidants ◽  
2018 ◽  
Vol 7 (9) ◽  
pp. 111 ◽  
Author(s):  
Shaarika Sarasija ◽  
Kenneth Norman
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Caenorhabditis Elegans ◽  
Mitochondrial Function ◽  
Calcium Dysregulation ◽  
Mitochondrial Oxidative Stress ◽  
Health Crisis ◽  
Genes Encoding

Neurodegenerative diseases like Alzheimer’s disease (AD) are poised to become a global health crisis, and therefore understanding the mechanisms underlying the pathogenesis is critical for the development of therapeutic strategies. Mutations in genes encoding presenilin (PSEN) occur in most familial Alzheimer’s disease but the role of PSEN in AD is not fully understood. In this review, the potential modes of pathogenesis of AD are discussed, focusing on calcium homeostasis and mitochondrial function. Moreover, research using Caenorhabditis elegans to explore the effects of calcium dysregulation due to presenilin mutations on mitochondrial function, oxidative stress and neurodegeneration is explored.

scholarly journals Role of SIRT1/PGC-1α in mitochondrial oxidative stress in autistic spectrum disorder

2017 ◽  
Vol Volume 13 ◽  
pp. 1633-1645 ◽  
Author(s):  
Xiaosong Bu ◽  
De Wu ◽  
Xiaomei Lu ◽  
Li Yang ◽  
Xiaoyan Xu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Autistic Spectrum Disorder ◽  
Spectrum Disorder ◽  
Mitochondrial Oxidative Stress ◽  
Autistic Spectrum

scholarly journals Role of Olive Oil and Monounsaturated Fatty Acids in Mitochondrial Oxidative Stress and Aging

2006 ◽  
Vol 64 (10) ◽  
pp. 31-39 ◽  
Author(s):  
José L. Quiles ◽  
Gustavo Barja ◽  
Maurizio Battino ◽  
José Mataix ◽  
Vincenzo Solfrizzi
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Olive Oil ◽  
Monounsaturated Fatty Acids ◽  
Mitochondrial Oxidative Stress

scholarly journals The role of mitochondrial oxidative stress in the metabolic alterations in diet‐induced obesity in rats

2019 ◽  
Vol 33 (11) ◽  
pp. 12060-12072 ◽  
Author(s):  
Gema Marín‐Royo ◽  
Cristina Rodríguez ◽  
Aliaume Le Pape ◽  
Raquel Jurado‐Lopez ◽  
María Luaces ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Oxidative Stress ◽  
Metabolic Alterations ◽  
Diet Induced Obesity
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