High prevalence of Somali population in children presenting with vitamin D deficiency in the UK

2010 ◽  
Vol 95 (7) ◽  
pp. 568-569 ◽  
Author(s):  
G. Modgil ◽  
B. Williams ◽  
G. Oakley ◽  
C. P. Burren
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
High Prevalence ◽  
The Uk

scholarly journals Very high prevalence of vitamin D deficiency in South Asian adults (n 6433) in the UK Biobank: urgent action required

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Andrea Darling ◽  
David Blackbourn ◽  
Kourosh Ahmadi ◽  
Susan Lanham-New
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
South Asian ◽  
South Asians ◽  
Uk Biobank ◽  
Baseline Serum ◽  
Asian Ethnicity ◽  
High Prevalence ◽  
South Asian Ethnicity ◽  
The Uk

AbstractPublished studies have suggested a high prevalence of 25-hydroxyvitamin D (25OHD) deficiency in western dwelling South Asians, particularly in women. However, sample sizes have been relatively small with few men. Moreover, South Asians are vastly under-represented in national dietary surveys and further research into 25(OH)D status is needed. The UK Biobank is a cohort of 500,000 individuals; n 6433 are of South Asian ethnicity and have baseline serum 25(OH)D data (2006–2010, aged 40–69 years). Blood draws were spread across the year. Of note, the 25(OH)D measurements were produced using the DiaSorin Liaison XL assay which underestimates 25(OH)D by 4% at 25nmol/L, but overestimates 25(OH)D by 5–10% at ≥ 40nmol/\L(1). We used the commonly used cut-points of < 25nmol/L (deficiency), < 50nmol/L (insufficiency). In women (n 2927), median (IQR) was 24.3 (20.5) nmol/L with 50.4% < 25nmol/L, and 88.6% < 50nmol/L. In men (n 3506), median (IQR) was 21.7 (16.2) with 58.4% < 25 nmol/L and 93.8% < 50 nmol/L. Of concern, 17.8% of women and 21.1% of men had 25(OH)D < 15nmol/L. A Mann Whitney test showed that gender differences were statistically significant (P < 0.0001). In terms of ethnic sub-groups, in the Bangladeshi group (n 207), median (IQR) was 26.1 (14.3) nmol/L with 43.5% < 25nmol/L and 91.3% < 50nmol/L. In the Indian group (n 4792), median (IQR) was 23.8 (19.3) with 52.0% < 25nmol/L and 90.4% < 50nmol/L. Finally, in the Pakistani group (n 1434) median (IQR) was 19.3(14.5) with 65.7% < 25nmol/L and 94.9% < 50nmol/L. A Kruskal Wallis test showed that ethnic subgroup differences were statistically significant (P < 0.0001). To the authors’ knowledge, this is the largest analysis to date of 25(OH)D status in European dwelling South Asians. Deficiency of 25(OH)D was almost universal, with 50% or more not even reaching 25nmol/L. Of great concern, 20% of participants had levels < 15nmol/L which, although not a widely used cut-off point, still represents severe deficiency and likely osteomalacia. Moreover, these results are most probably an underestimation of this societal challenge as the UK Biobank is likely to contain participants that are healthier and more educated than the general population. In conclusion, our analyses suggest the need for urgent public health interventions to prevent and treat vitamin D deficiency in UK South Asians. This research was conducted using the UK Biobank Resource under application number 15168.

High Prevalence of Vitamin D Deficiency among LVAD Patients

2015 ◽  
Vol 63 (S 01) ◽  
Author(s):  
M. von Stumm ◽  
D. Knappe ◽  
M.J. Barten ◽  
A. Bernhardt ◽  
F. Wagner ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
High Prevalence

The Prevalence of Vitamin D Deficiency in Iran: A Literature Review

2020 ◽  
Vol 16 (7) ◽  
pp. 1015-1027
Author(s):  
Mohammad Bagherniya ◽  
Zahra Khorasanchi ◽  
Mina S. Bidokhti ◽  
Gordon A. Ferns ◽  
Mitra Rezaei ◽  
...  
Keyword(s):  
Vitamin D ◽  
Literature Review ◽  
Vitamin D Deficiency ◽  
Medical Condition ◽  
Scientific Information ◽  
Age Groups ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Vitamin D Levels ◽  
High Prevalence

Background: Vitamin D deficiency is a common medical condition worldwide. In Iran, it has been reported that between 30-90% of people have vitamin D deficiency. However, its distribution in different parts of the country and among different age and regional groups is unclear. Therefore, the aim of this study was to review the recent literature on vitamin D deficiency in Iran. Methods: The literature review was performed using Web of Science, PubMed-Medline, Scopus and Scientific Information Database (SID) with a cut-off date of November 2016 to identify articles on vitamin D status in Iran published in the last 10 years. Studies in English and Persian that reported vitamin D levels in male and female subjects of all age groups and in healthy populations were included. Results: From 325 studies that were initially retrieved, 82 articles met the inclusion criteria. A high prevalence of vitamin D deficiency was reported, and in some regions, this was reported as >90% and was found in all age groups and in all regions of Iran. Conclusion: This review highlights the very high prevalence of vitamin D deficiency in Iran. It will be important to recognize the importance of vitamin D deficiency as a major public health problem in Iran.

High Prevalence of Vitamin D Deficiency in Patients with Bone Tumors

2017 ◽  
Vol 35 (8) ◽  
pp. 562-568 ◽  
Author(s):  
Konstantin Horas ◽  
Gerrit Maier ◽  
Franz Jakob ◽  
Uwe Maus ◽  
Andreas Kurth ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bone Tumors ◽  
High Prevalence

scholarly journals High Prevalence of Vitamin D Deficiency in Pregnant Korean Women: The First Trimester and the Winter Season as Risk Factors for Vitamin D Deficiency

Nutrients ◽  
2015 ◽  
Vol 7 (5) ◽  
pp. 3427-3448 ◽  
Author(s):  
Rihwa Choi ◽  
Seonwoo Kim ◽  
Heejin Yoo ◽  
Yoon Cho ◽  
Sun Kim ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Winter Season ◽  
First Trimester ◽  
Korean Women ◽  
High Prevalence

scholarly journals High prevalence of vitamin D deficiency in elderly patients with advanced osteoarthritis scheduled for total knee replacement associated with poorer preoperative functional state

2013 ◽  
Vol 95 (8) ◽  
pp. 569-572 ◽  
Author(s):  
JA Jansen ◽  
FS Haddad
Keyword(s):  
Vitamin D ◽  
Total Knee Replacement ◽  
Elderly Patients ◽  
Knee Osteoarthritis ◽  
Vitamin D Deficiency ◽  
Knee Replacement ◽  
Functional State ◽  
High Prevalence ◽  
Outcome Scores ◽  
Total Knee

Vitamin D deficiency has been reported previously in patients with osteoarthritis undergoing total hip arthroplasty. We found a high prevalence of vitamin D deficiency in elderly patients with advanced knee osteoarthritis scheduled for total knee replacement and also a significant association with a lower preoperative functional state. A review of the literature is given on vitamin D deficiency in patients with knee osteoarthritis and the association with lower outcome scores after arthroplasty is discussed.

scholarly journals Vitamin D deficiency and health

2010 ◽  
Vol 16 (3) ◽  
pp. 277-281 ◽  
Author(s):  
I. L. Nikitina ◽  
T. L. Karonova ◽  
E. N. Grineva
Keyword(s):  
Vitamin D ◽  
Clinical Trials ◽  
Vitamin D Deficiency ◽  
Wide Spectrum ◽  
Increased Risk ◽  
High Prevalence

The high prevalence of vitamin D defi ciency worldwide and the associated increased risk for different pathologies require re-evaluation of this problem and its signifi cance. The wide spectrum of the diseases associated with vitamin D defi ciency explains the high scientifi c interest and increasing number of clinical trials in this area, and the involvement of larger populations into studies.

scholarly journals 925Ethnic differences and determinants of vitamin D deficiency in the UK Biobank

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Joshua Sutherland ◽  
Ang Zhou ◽  
Matthew Leach ◽  
Elina Hyppönen
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Asian Population ◽  
European Ancestry ◽  
Uk Biobank ◽  
Mixed Ancestry ◽  
Black African ◽  
Hydroxyvitamin D ◽  
The Uk ◽  
Summer Time

Abstract Background While controversy remains regarding optimal vitamin D status, the public health relevance of true vitamin D deficiency is undisputed. There are few contemporary cross-ethnic studies investigating the prevalence and determinants of very low 25-hydroxyvitamin D [25(OH)D] concentrations. Methods We used data from 440,581 UK Biobank participants, of which 415,903 identified as white European, 7,880 Asian, 7,602 black African, 1,383 Chinese, and 6,473 of mixed ancestry. 25(OH)D concentrations were measured by DiaSorin Liaison XL and deficiency defined as ≤ 25 nmol/L 25(OH)D. Results The prevalence of 25(OH)D deficiency was highest among participants of Asian ancestry (57.2% in winter/spring and 50.8% in summer/autumn; followed by black African [38.47%/30.78%], mixed ancestry [36.53%/22.48%], Chinese [33.12%/20.68%] and white European [17.45%/5.90%], P &lt; 1.0E-300). Participants with higher socioeconomic deprivation were more likely to have 25(OH)D deficiency compared to less deprived (P &lt; 1.0E-300 for all comparisons), with the pattern being more apparent among those of white European ancestry and in summer (Pinteraction&lt;6.4E-5 for both). In fully-adjusted analyses, regular consumption of oily fish was effective in mitigating ≤25 nmol/L 25(OH)D deficiency across all ethnicities, whilst outdoor-summer time was less effective for black Africans than white Europeans (OR: 0.89; 95% CI: 0.70, 1.12 and OR: 0.40; 95% CI: 0.38, 0.42, respectively). Conclusions Vitamin D deficiency remains an issue throughout the UK, particularly in lower socioeconomic areas and the UK Asian population, half of whom have vitamin D deficiency across seasons. Key messages The prevalence of 25(OH)D deficiency in the UK is alarming, with certain ethnic and socioeconomic groups considered particularly vulnerable.

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