scholarly journals Effect of alpha thalassaemia trait and enhanced gamma chain production on disease severity in beta thalassaemia major and intermedia.

1994 ◽  
Vol 70 (1) ◽  
pp. 30-34 ◽  
Author(s):  
P Gringras ◽  
B Wonke ◽  
J Old ◽  
A Fitches ◽  
D Valler ◽  
...  
Keyword(s):  
Disease Severity ◽  
Thalassaemia Major ◽  
Gamma Chain ◽  
Beta Thalassaemia ◽  
Thalassaemia Trait ◽  
Alpha Thalassaemia

scholarly journals Thalassaemia genes in Baghdad, Iraq

2021 ◽  
Vol 2 (2) ◽  
pp. 315-319
Author(s):  
Hassan I. Yahya ◽  
Khalid J. Khalel ◽  
Nasir A. S. Al AlIawi ◽  
Ferial Helmi
Keyword(s):  
Maternity Care ◽  
Screening Test ◽  
Mean Corpuscular Volume ◽  
Corpuscular Volume ◽  
Prevalence Rates ◽  
Care Clinic ◽  
Beta Thalassaemia ◽  
Thalassaemia Trait ◽  
Alpha Thalassaemia ◽  
The City

To estimate the prevalence of thalassaemia genes in Baghdad, a study was made of 502 randomly selected pregnant women attending a major maternity care clinic in the city. A reduced mean corpuscular volume [MCV] of < 80 fl was used as a screening test for thalassaemia in this population, followed by a battery of tests, including haemoglobin analysis and iron studies, to confirm the diagnosis. Using this approach, 22 cases were diagnosed of beta-thalassaemia trait, five cases of alpha-thalassaemia trait and one case of delta beta-thalassaemia trait. Based on these figures the estimated prevalence rates of beta-, alpha- and delta beta-thalassaemia traits in Baghdad, would be 4.4%, 1.0% and 0.2%, respectively. The study also includes a discussion of the above findings in the context of those reported in other neighbouring countries

Reproductive health issues in female patients with beta-thalassaemia major: a narrative literature review

2020 ◽  
Vol 40 (7) ◽  
pp. 902-911 ◽  
Author(s):  
Malihe Nourollahpour Shiadeh ◽  
Elena Cassinerio ◽  
Maryam Modarres ◽  
Armin Zareiyan ◽  
Zeinab Hamzehgardeshi ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Literature Review ◽  
Thalassaemia Major ◽  
Health Issues ◽  
Female Patients ◽  
Beta Thalassaemia ◽  
Narrative Literature ◽  
Narrative Literature Review

Porphyria cutanea tarda and beta-thalassaemia major: causal or casual?

2010 ◽  
Vol 24 (10) ◽  
pp. 1242-1243 ◽  
Author(s):  
P Papadantonakis ◽  
O Neofotistou ◽  
A Vasiliadi ◽  
A Skoutelis ◽  
A Tsatsakis ◽  
...  
Keyword(s):  
Porphyria Cutanea Tarda ◽  
Thalassaemia Major ◽  
Beta Thalassaemia

scholarly journals Effectiveness and Safety of Sitagliptin in Patients with Beta-thalassaemia Major and Diabetes Mellitus: A Case Series

2016 ◽  
Vol 9 (1) ◽  
pp. e2017004 ◽  
Author(s):  
Shahrzad Zonoozi
Keyword(s):  
Diabetes Mellitus ◽  
Case Series ◽  
Close Monitoring ◽  
Thalassaemia Major ◽  
Efficacy And Safety ◽  
Antidiabetic Agent ◽  
Retrospective Case ◽  
Beta Thalassaemia ◽  
Equivalent Reduction

Sitagliptin, a modern antidiabetic agent which is weight neutral and associated with low rate of hypoglycaemias, is being increasingly used in type 2 diabetes mellitus (DM). However there is paucity of data about its efficacy and safety in beta-thalassaemia major (β-TM).This retrospective case series of five patients (mean age of 45 years) is the first study evaluating the use of sitagliptin in patients with β-TM and DM.Four patients responded well to sitagliptin, as evidenced by decrease in fructosamine by 77 and 96µmol/L (equivalent reduction in HbA1c of 1.5% and 1.9%) observed in two patients and reduction in the frequency of hypoglycaemia without worsening glycaemic control in two others. One patient did not respond to sitagliptin. No patients reported significant side effects.This study provides evidence that sitagliptin may be considered, with caution, for use in patients with β-TM and DM, under the close monitoring of a Diabetologist.

scholarly journals Screening for hemoglobinopathies in a socially disadvantaged population from a rural district of West Bengal, India

2020 ◽  
Vol 8 (12) ◽  
pp. 4430
Author(s):  
Prakas Kumar Mandal ◽  
Tuphan Kanti Dolai ◽  
Soma Mandal ◽  
Tamanash Mondal ◽  
Suman Kumar Maji
Keyword(s):  
West Bengal ◽  
Sickle Cell Trait ◽  
Venous Blood ◽  
Rural District ◽  
Compound Heterozygous ◽  
Reference Laboratory ◽  
General Category ◽  
Beta Thalassaemia ◽  
Thalassaemia Trait ◽  
Scheduled Castes

Background: Detection of traits/carriers plays an important role in preventing the birth of a thalassemic child. West Bengal, one of the eastern states in India is the home to a bulk of socially challenged population including scheduled castes and scheduled tribes among others. The present study aimed to detect the prevalence of different hemoglobinopathies in a socially challenged district of West Bengal.Methods: In this retrospective cross sectional study thalassemia detection camps were organized at the community level over a period of four years. Venous blood samples were subjected to complete hemogram and high performance liquid chromatography (HPLC). In few difficult cases samples were sent to the reference laboratory for molecular characterization. The prevalence of heterozygous, homozygous or compound heterozygous states of different thalassemias and hemoglobinopathies across various respondent groups (e.g. children, premarital, postmarital and antenatal) and existing caste categories (scheduled tribes, scheduled caste and general) were analyzed.Results: We analyzed a total of 114,606 HPLC reports; 18681 (16.30%), 15438 (13.47%) and 80487 (70.23%) cases belonged to scheduled tribes, scheduled castes and general category respectively. Out of 114,606 cases, 11,001 (9.6%) had revealed abnormal hemoglobins; beta thalassaemia trait was the most common (6.63%; n=7602) across all subgroup analysis. Among others, HbE trait, sickle cell trait and HbD trait were detected in 1788 (1.56%), 1362 (1.18%) and 126 (0.11%) cases respectively.Conclusions: Beta thalassaemia trait and HbE trait are the common haemoglobin variants in this rural district of West Bengal. The prevalence of sickle gene revealed in the present study is much less than previous studies in the locality.

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