Cross-sectional and longitudinal associations between systemic, subchondral bone mineral density and knee cartilage thickness in older adults with or without radiographic osteoarthritis

2013 ◽  
Vol 73 (11) ◽  
pp. 2003-2009 ◽  
Author(s):  
Yuelong Cao ◽  
Oliver P Stannus ◽  
Dawn Aitken ◽  
Flavia Cicuttini ◽  
Benny Antony ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Older Adults ◽  
Bone Mineral ◽  
Subchondral Bone ◽  
Cartilage Thickness ◽  
Knee Cartilage ◽  
Mineral Density ◽  
Cross Sectional ◽  
Radiographic Osteoarthritis ◽  
Longitudinal Associations

scholarly journals Cross-sectional and longitudinal associations between circulating leptin and knee cartilage thickness in older adults

2013 ◽  
Vol 74 (1) ◽  
pp. 82-88 ◽  
Author(s):  
Oliver P Stannus ◽  
Yuelong Cao ◽  
Benny Antony ◽  
Leigh Blizzard ◽  
Flavia Cicuttini ◽  
...  
Keyword(s):  
Older Adults ◽  
Body Fat ◽  
Serum Levels ◽  
Cartilage Thickness ◽  
Knee Cartilage ◽  
Cross Sectional ◽  
Serum Leptin ◽  
Negatively Associated ◽  
Radiographic Osteoarthritis ◽  
Longitudinal Associations

ObjectiveTo investigate cross-sectional and longitudinal associations between serum leptin levels and knee cartilage thickness in older adults.MethodsA prospective cohort of 163 randomly selected subjects (mean 63 years, range 52–78, 46% women) was studied. Knee cartilage thickness at medial tibial, lateral tibial, femoral and patellar sites was determined using T1-weighted fat-suppressed MRI. Serum leptin levels were measured by radioimmunoassay. Radiographic osteoarthritis, body fat (%), trunk fat (%), weight and height were measured, and body mass index (BMI) was calculated.ResultsCross-sectionally, serum levels of leptin were negatively associated with femoral (β: −0.013, 95% CI −0.022 to −0.003), medial tibial (β: −0.009, 95% CI −0.018 to −0.001), lateral tibial (β: −0.012, 95% CI −0.021 to −0.003) and patellar (β: −0.014, 95% CI −0.026 to −0.002) cartilage thickness after adjustment for covariates. Moreover, BMI, trunk fat and total body fat were negatively associated with cartilage thickness, and the significant associations disappeared after further adjustment for leptin. Longitudinally, both baseline leptin and change in leptin were associated with greater changes in medial tibial cartilage thickness (β: −0.004, 95% CI −0.007 to −0.001 and β: −0.009, 95% CI −0.018 to −0.001, respectively) in multivariable analyses.ConclusionsSerum levels of leptin are independently and consistently associated with reduced cartilage thickness cross-sectionally and longitudinally. In addition, the associations between adiposity measures and cartilage thickness are mediated by leptin, suggesting leptin may play a key role in cartilage thinning.

Factors Influencing Bone Mineral Density Among Adults of Delhi: A Gender Differential

2019 ◽  
Vol 21 (2) ◽  
pp. 199-209 ◽  
Author(s):  
Peteneinuo Rulu ◽  
Meenal Dhall ◽  
Renu Tyagi ◽  
Kshetrimayum Surmala Devi ◽  
Nilupher Feroz ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Older Adults ◽  
Bone Mineral ◽  
Fat Body ◽  
Mineral Density ◽  
Cross Sectional ◽  
Body Adiposity Index ◽  
Adiposity Index ◽  
Body Adiposity ◽  
Males And Females

Objective: The aim of the study was to find out the risk factor of bone mineral density (BMD). Methodology: Cross-sectional data were collected on 233 participants (males and females) with age ranging from 20 to 70 years. The subjects were divided into two groups consisting of young adults of 20–45 years and older adults of >45 years. The BMD was calculated by a heel ultrasonic test. Each subject was measured for various adiposity markers like body fat, body mass index, body shape index (BSI), body adiposity index and lifestyle parameters. Results: BSI was found to be higher among older adults in both males and females. The risk of osteoporosis and osteopenia was also seen to be significantly higher among older adults of >45 years ( p < 0.001). Various factors like age ( p < 0.001), milk intake status ( p < 0.05), education ( p < 0.01), occupation ( p < 0.05) and body adiposity index ( p < 0.05) were found to be risks for osteoporosis and osteopenia. Conclusion: In our study, BMD was found to be highly correlated with age, and the risk of osteopenia and osteoporosis increased as age increased. Illiteracy, milk consumption status, homemakers and higher body adiposity were also identified as risk factors for developing osteopenia and osteoporosis.

scholarly journals Association between knee cartilage volume and bone mineral density in older adults without osteoarthritis

Rheumatology ◽  
2004 ◽  
Vol 43 (6) ◽  
pp. 765-769 ◽  
Author(s):  
F. Cicuttini ◽  
A. Wluka ◽  
S. Davis ◽  
B. J. G. Strauss ◽  
S. Yeung ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Older Adults ◽  
Bone Mineral ◽  
Cartilage Volume ◽  
Knee Cartilage ◽  
Mineral Density

scholarly journals The sex-specific association of serum osteoprotegerin and receptor activator of nuclear factor κB legend with bone mineral density in older adults: the Rancho Bernardo Study

2007 ◽  
Vol 156 (5) ◽  
pp. 555-562 ◽  
Author(s):  
Anna Stern ◽  
Gail A Laughlin ◽  
Jaclyn Bergstrom ◽  
Elizabeth Barrett-Connor
Keyword(s):  
Bone Mineral Density ◽  
Older Adults ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Mineral Density ◽  
Cross Sectional ◽  
Total Hip ◽  
Receptor Activator

Objective: The role of osteoprotegerin (OPG) and its receptor activator of nuclear factor κB legend (RANKL) in the regulation of bone in humans remain unclear. We examined the sex-specific associations of serum OPG, RANKL, and their ratio with bone mineral density (BMD) in older adults. Design: Participants were 681 community-dwelling adults, ages 45–90 years, who had serum OPG and RANKL measured and bone density scans in 1988–1991, with follow-up scans 5 and/or 10 years later. Methods: Analyses were sex-specific; women using and not using estrogen were evaluated separately. Cross-sectional analyses used multivariable regression models; longitudinal analyses used repeated measures mixed effects models. Results: In cross-sectional analyses, age- and weight-adjusted serum OPG levels were significantly positively associated with BMD at the lumbar spine in men, and at the femoral neck, total hip, and lumbar spine in women using estrogen, but not in non-users of estrogen. RANKL concentrations were significantly and inversely associated with BMD in men only, and at the total hip. Neither OPG nor RANKL was significantly associated with bone loss. Results for the RANKL/OPG ratio were the same as those for RANKL alone. Conclusions: These results suggest a modulatory effect of both endogenous and exogenous sex hormones on the biologic interaction of OPG, RANKL, and bone.

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