THU0528 How Kidneys, Heart and Liver Change When Tophi Are Present?

110 Background: Anthracycline chemotherapy has been associated with radiation-induced liver disease (RILD). We sought to compare the incidence of liver toxicity among patients with gastric adenocarcinoma treated with radiotherapy (RT) with or without epirubicin-based chemotherapy. Methods: We performed a retrospective analysis of 94 patients with gastric adenocarcinoma treated at Massachusetts General Hospital since November 2005 and the Dana-Farber Cancer Institute since August 1998. All patients underwent definitive surgery and RT (median dose 45 Gray) with a minimum follow up of 6 months. Primary endpoints were development of ascites, radiographic liver change and elevations in liver function tests (LFTs), including alkaline phosphatase (ALP), aspartate transaminase (AST) and alanine transaminase (ALT). Results: In total, 34 patients received epirubicin-based chemotherapy including 9 perioperatively (6 with oxaliplatin and capecitabine [EOX]; 2 with cisplatin and 5-flourouracil [ECF]; 1 with oxaliplatin and 5-flourouracil [EOF]) and 25 postoperatively (2 EOX; 22 ECF; 1 combination). Seven patients were treated with neoadjuvant RT; 87 received adjuvant RT a median of 88 days after surgery (interquartile range 73-108 days). Twenty-one patients developed ascites within 6 months of completing RT, all but one of whom developed peritoneal carcinomatosis or metastatic disease. Among 57 patients that did not develop metastases, maximum elevations in LFTs were similar in patients that received epirubicin-based chemotherapy compared to those who did not (ALP/AST/ALT 150/44/50 vs. 142/41/44, p=0.25/0.36/0.14, respectively), as were rates of radiographic liver change (22% vs. 13%, p=0.44). Conclusions: Epirubicin-based chemotherapy does not significantly increase the risk of RILD in a recent cohort of patients treated with modern RT techniques and dose-constraints. In this setting, treatment of gastric adenocarcinoma with RT and either pre- or postoperative chemotherapy is well tolerated with low rates of liver toxicities. Development of liver toxicity, particularly ascites, within six months of RT may be a harbinger of metastatic disease. No significant financial relationships to disclose.

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Relationship Between Fatty Liver Change and Nutritional Status After Total Gastrectomy in Gastric Cancer Patients: A Retrospective Study

10.21203/rs.3.rs-109285/v1 ◽

2020 ◽

Author(s):

Naohiko Nakamura ◽

Shinichi Kinami ◽

Jun Fujita ◽

Daisuke Kaida ◽

Yasuto Tomita ◽

...

Keyword(s):

Gastric Cancer ◽

Fatty Liver ◽

Total Gastrectomy ◽

Total Protein ◽

Skeletal Muscle Index ◽

Nutritional Parameters ◽

Computed Tomography Images ◽

Liver Change ◽

Significant Difference ◽

The Mean

Abstract Background: The relationship between chronological nutritional changes and development of fatty liver after total gastrectomy (TG) in gastric cancer (GC) patients is still unclear. This study aimed to evaluate relationship between development of fatty liver and chronological changes of nutritional parameters during 12 months after TG.Methods: We retrospectively analyzed medical records of 59 patients with GC who underwent TG at the Kanazawa Medical University Hospital between January 2009 and December 2017. We defined fatty liver change as a mean liver-to-spleen attenuation ratio (L/S ratio) of less than 1.2 in the computed tomography images at 12 months after TG and divided the patients into fatty liver (FL) and non-FL groups from the L/S ratio. We analyzed serum levels of total protein and albumin, and psoas muscle index (PMI) before TG and at 6 and 12 months after TG in the non-FL and FL groups. Results: Six patients showed an L/S ratio of less than 1.2 at 12 months after TG and were included into FL group. There was no significant difference between the groups in serum parameters, L/S ratio, and PMI before TG. In the FL group, the mean levels of total protein and albumin decreased after TG and were significant lower at 6 months, compared with the non-FL group. And then, these levels in the FL group recovered at 12 months. In contrast, the mean levels of total protein and albumin in the non-FL group did not decrease below the preoperative levels throughout the year after surgery. As with laboratory parameters, all patients in the FL group showed decrease of PMI at 6 months after TG. This proportion was significantly higher than that in the non-FL group (100% vs 40.8%, P = 0.006).Conclusions: We evaluated that the patients with fatty liver occurring after TG had significantly lower levels of serum nutritional parameters and skeletal muscle index at 6 months, not but 12 months, after TG.

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Frequently abnormal serum gamma-glutamyl transferase activity is associated with future development of fatty liver: a retrospective cohort study

10.21203/rs.3.rs-19610/v2 ◽

2020 ◽

Author(s):

Hideki Fujii ◽

Haruna Doi ◽

Tetsuhisa Ko ◽

Taito Fukuma ◽

Toru Kadono ◽

...

Keyword(s):

Cohort Study ◽

Propensity Score ◽

Fatty Liver ◽

Propensity Score Matching ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Incidence Rates ◽

Gamma Glutamyl Transferase ◽

Liver Change ◽

Glutamyl Transferase

Abstract Background Nonalcoholic fatty liver disease is characterized by excessive hepatic fat accumulation. Some individuals frequently present elevated gamma-glutamyl transferase (GGT) levels without fatty liver ultrasound images and other abnormal liver enzymes levels. However, whether these individuals are at an elevated risk for developing fatty liver is unclear. We compared fatty liver change rates and risk factors between individuals with frequently elevated GGT levels and those with normal levels.Methods We designed a retrospective cohort study on the basis of complete medical checkup records. One group of individuals had presented normal serum GGT levels during the observation period (Normal-GGT group, n = 2713). Another group had had abnormal elevated serum GGT levels frequently (Abnormal-GGT group, n = 264). We determined the fatty liver change incident rates before and after propensity score matching. We explored confounding factors affecting fatty changes in each group using univariate and multivariate Cox models.Results The change incidence rates were 5.80/1000 and 10.02/1000 person-years in the Normal-GGT and Abnormal-GGT groups, respectively. After propensity score matching, the incidence rates were 3.08/1000 and 10.18/1000 person-years in the Normal-GGT and Abnormal-GGT groups, respectively (p = 0.026). The factors associated with fatty liver changes in the Normal-GGT group included body mass index (BMI), hemoglobin, alanine aminotransferase (ALT), albumin, triglyceride (TG), fasting blood sugar, and high-density lipoprotein levels. Those in the Abnormal-GGT group were platelet counts and TG. In our multivariable analysis, BMI, ALT, albumin, and TG levels were independent predictors of fatty changes in the Normal-GGT group, and high TG level was the only independent predictor in the Abnormal-GGT group.Conclusions The incidence rate of fatty liver change in the Abnormal-GGT group was higher than that in the Normal-GGT group. Consecutive elevated GGT levels increase the risk for fatty liver, and high TG levels in those individuals further independently increase the risk.Trial registration: NA

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Analysis of hepatic gene expression during fatty liver change due to chronic ethanol administration in mice

Toxicology and Applied Pharmacology ◽

10.1016/j.taap.2008.12.018 ◽

2009 ◽

Vol 235 (3) ◽

pp. 312-320 ◽

Cited By ~ 19

Author(s):

Hu-Quan Yin ◽

Young-Tae Je ◽

Mingoo Kim ◽

Ju-Han Kim ◽

Gu Kong ◽

...

Keyword(s):

Gene Expression ◽

Fatty Liver ◽

Chronic Ethanol ◽

Ethanol Administration ◽

Hepatic Gene Expression ◽

Liver Change ◽

Chronic Ethanol Administration

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P-19 Does the ratio of the A and B isoforms of the insulin receptor of the liver change with diabetic status?

Diabetes Research and Clinical Practice ◽

10.1016/s0168-8227(08)70793-9 ◽

2008 ◽

Vol 79 ◽

pp. S61

Author(s):

Mark T. Hayes ◽

Fiona Y.S. Kwan ◽

Daniel Hutchings ◽

Richard S. Stubbs

Keyword(s):

Insulin Receptor ◽

Diabetic Status ◽

Liver Change

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Ultrastructure of acute tetracycline induced liver change

Cellular and Molecular Life Sciences ◽

10.1007/bf02286930 ◽

1971 ◽

Vol 27 (10) ◽

pp. 1204-1205 ◽

Cited By ~ 7

Author(s):

I. Damjanov ◽

D. Solter

Keyword(s):

Liver Change

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Focal fatty liver change in a 12-year-old Japanese boy

European Journal of Pediatrics ◽

10.1007/s004310050168 ◽

1994 ◽

Vol 153 (6) ◽

pp. 429-431 ◽

Cited By ~ 1

Author(s):

M. Igarashi ◽

T. Nakamura ◽

S. Ohtsuki ◽

Y. Nakashima ◽

Y Akiyama

Keyword(s):

Fatty Liver ◽

Liver Change ◽

Old Japanese

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Does Donor’s Fatty Liver Change Impact on Early Mortality and Outcome of Liver Transplantation

Transplantation Proceedings ◽

10.1016/j.transproceed.2007.04.014 ◽

2007 ◽

Vol 39 (4) ◽

pp. 1181-1183 ◽

Cited By ~ 27

Author(s):

S. Nikeghbalian ◽

S.M.R. Nejatollahi ◽

H. Salahi ◽

A. Bahador ◽

B. Sabet ◽

...

Keyword(s):

Liver Transplantation ◽

Fatty Liver ◽

Early Mortality ◽

Liver Change ◽

Change Impact

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Relationship between fatty liver change and nutritional status after total gastrectomy in gastric cancer patients: a retrospective study

BMC Surgery ◽

10.1186/s12893-021-01324-x ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Naohiko Nakamura ◽

Shinichi Kinami ◽

Jun Fujita ◽

Daisuke Kaida ◽

Yasuto Tomita ◽

...

Keyword(s):

Gastric Cancer ◽

Fatty Liver ◽

Total Gastrectomy ◽

Total Protein ◽

Skeletal Muscle Index ◽

Nutritional Parameters ◽

Computed Tomography Images ◽

Liver Change ◽

Significant Difference ◽

The Mean

Abstract Background The relationship between chronological nutritional changes and development of fatty liver after total gastrectomy (TG) in gastric cancer (GC) patients is still unclear. This study aimed to evaluate relationship between development of fatty liver and chronological changes of nutritional parameters during 12 months after TG. Methods We retrospectively analyzed medical records of 59 patients with GC who underwent TG at the Kanazawa Medical University Hospital between January 2009 and December 2017. We defined fatty liver change as a mean liver-to-spleen attenuation ratio (L/S ratio) of less than 1.2 in the computed tomography images at 12 months after TG and divided the patients into fatty liver (FL) and non-FL groups from the L/S ratio. We analyzed serum levels of total protein and albumin, and psoas muscle index (PMI) before TG and at 6 and 12 months after TG in the non-FL and FL groups. Results Six patients showed an L/S ratio of less than 1.2 at 12 months after TG and were included into FL group. There was no significant difference between the groups in serum parameters, L/S ratio, and PMI before TG. In the FL group, the mean levels of total protein and albumin decreased after TG and were significant lower at 6 months, compared with the non-FL group. And then, these levels in the FL group recovered at 12 months. In contrast, the mean levels of total protein and albumin in the non-FL group did not decrease below the preoperative levels throughout the year after surgery. As with laboratory parameters, all patients in the FL group showed decrease of PMI at 6 months after TG. This proportion was significantly higher than that in the non-FL group (100% vs. 40.8%, P = 0.006). Conclusions We evaluated that the patients with fatty liver occurring after TG had significantly lower levels of serum nutritional parameters and skeletal muscle index at 6 months, not but 12 months, after TG.

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