THU0502 Comparison of Low Doses of Systemic Corticosteroids Therapy in Diabetic Patients with Oligoarticular or Polyarticular Gout Flares: An Observational Retrospective Study

2016 ◽  
Vol 75 (Suppl 2) ◽  
pp. 373.3-374
Author(s):  
C.A. Guillen-Astete ◽  
A. Boteanu ◽  
M. Villarejo-Botija
Keyword(s):  
Retrospective Study ◽  
Diabetic Patients ◽  
Low Doses ◽  
Systemic Corticosteroids ◽  
Gout Flares

Retrospective Study on Hospital Admissions due to Pyelonephritis in Type II Diabetic Patients

2021 ◽  
Vol 5 (6) ◽  
Author(s):  
Dilraj Dhillon ◽  
Thomas Randall ◽  
David Zezoff ◽  
Mouchumi Bhattacharyya
Keyword(s):  
Retrospective Study ◽  
Length Of Stay ◽  
Hospital Admissions ◽  
Type Ii Diabetes Mellitus ◽  
Hospitalized Patients ◽  
Diabetic Patients ◽  
Clean Intermittent Catheterization ◽  
Type Ii ◽  
Indwelling Catheters ◽  
Significant Difference

Background: Pyelonephritis is a urinary tract infection that ascends to involve the kidneys. It can also occur as an infection secondary to bacteremia. Some pathogens that commonly cause pyelonephritis are E. coli, enterobacteriaceae, staphylococci, and pseudomonas. The initial patient presentation usually involves fever, chills, nausea, vomiting, costovertebral angle tenderness, and flank pain. Other cystitis symptoms such as dysuria, increased urinary frequency, malodorous urine, and hematuria may or may not be present. Symptoms of pyelonephritis with bacteriuria are sufficient for the diagnosis of pyelonephritis. Aim: The aim of this study was to investigate a potential link between Type II Diabetes Mellitus and pyelonephritis. Methods: In this retrospective study, hospitalized patients during the study period were reviewed. Variables examined were sex, age, and length of stay. Patients were excluded if they had known urogenital abnormalities, indwelling catheters (Foley, nephrostomy, suprapubic, or who regularly perform clean intermittent catheterization), were pregnant, or were on dialysis. Results: Of 333 patients analyzed, diabetics had a longer length of stay then non-diabetics (4.49 vs 3.67 days respectively; p=0.0041) and females were significantly younger than men in hospitalized patients for pyelonephritis were (50.0 vs 63.5 years; p=<0.0001). Further, it was found that diabetics were significantly older than nondiabetics were (60.4 vs 47.3; p=<0.0001) and more diabetics getting admitted with pyelonephritis were men vs women (59.32% vs 35.27%; p=0.0007). Conclusion: Results of the study were significant in showing that of all pyelonephritis-hospitalized patients on average the length of stay was longer for diabetics and it demonstrated that female patients with pyelonephritis are significantly younger than male patients hospitalized with pyelonephritis. Of note, there was no significant difference in the length of stay for diabetic patients based on their treatment modality (diet controlled vs. oral medications vs. insulin dependent vs. combined). The study also showed that diabetics getting admitted for pyelonephritis are more men and older in age compared to the nondiabetics.

Utility of Anakinra in Acute Crystalline Diseases: A Retrospective Study Comparing a University Hospital with a Veterans Affairs Medical Center

2018 ◽  
Vol 46 (7) ◽  
pp. 748-750 ◽  
Author(s):  
Julianna Desmarais ◽  
Cong-Qiu Chu
Keyword(s):  
Retrospective Study ◽  
Adverse Effects ◽  
Medical Center ◽  
Veterans Affairs ◽  
Hospitalized Patients ◽  
University Hospital ◽  
Acute Gout ◽  
Efficacy And Safety ◽  
Inpatient Management ◽  
Gout Flares

Objective.To evaluate the efficacy and safety of anakinra in inpatient management of acute gout and pseudogout.Methods.Hospitalized patients with acute gout (n = 77) or pseudogout (n = 11) or both (n = 3) were analyzed for response to anakinra and adverse effects.Results.Half of all patients had comorbidities limiting the treatment choice. Anakinra was well tolerated, and 92% of gout flares and 79% of pseudogout flares responded to treatment.Conclusion.Anakinra is an effective and safe treatment for acute gout and pseudogout in hospitalized patients, particularly in those with comorbidities.

Cell Therapy and Peripheral Artery Disease: Diabetics first!

2021 ◽  
Author(s):  
Bertrand Lehalle ◽  
Arnaud Dosda ◽  
Philippe Jan ◽  
Jean-François Stoltz
Keyword(s):  
Retrospective Study ◽  
Cell Therapy ◽  
Peripheral Artery Disease ◽  
Specific Problem ◽  
Foot Ulcers ◽  
Diabetic Patients ◽  
Clinical Expertise ◽  
Peripheral Artery ◽  
Arterial Revascularization ◽  
Artery Disease

Drawing on our clinical expertise with diabetic patients and on a retrospective study focused on patients with foot ulcers or wounds and Peripheral Artery Disease, we show a healing problem exists specifically in diabetic patients, despite arterial revascularization. To overcome this specific problem, Cell Therapy could be a way, exclusively aimed at diabetic patients. We explain the reasons why, as well as the ways and means, and more particularly the concept of tissue reversibility.

scholarly journals The health behaviour of black insulin dependent diabetic patients

Curationis ◽  
1991 ◽  
Vol 14 (2) ◽  
Author(s):  
G.L. Xaba ◽  
S.R. Dewar
Keyword(s):  
Retrospective Study ◽  
Registered Nurses ◽  
Health Behaviour ◽  
Interaction Model ◽  
Affective Responses ◽  
Diabetic Patients ◽  
Structured Interviews ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

This descriptive retrospective study explores the perceptions and experiences relating to their discease of 20 adult Black insulin - dependent diabetic clients in terms of Cox’s Interaction Model of Client Health Behaviour. Cognitive and affective responses were investigated by means of structured interviews. Questionnaires completed by 30 registered nurses examined by their impressions of diabetic patients’ motivation and levels of satisfaction with their care. Findings are discussed and recommendations made.

Outcome of Carpal Tunnel Release in Diabetic Patients

1994 ◽  
Vol 19 (5) ◽  
pp. 626-629 ◽  
Author(s):  
M. M. AL-QATTAN ◽  
R. T. MANKTELOW ◽  
C. V. A. BOWEN
Keyword(s):  
Retrospective Study ◽  
Peripheral Neuropathy ◽  
Carpal Tunnel ◽  
Nerve Conduction ◽  
Complete Resolution ◽  
Carpal Tunnel Release ◽  
Nerve Conduction Studies ◽  
Diabetic Patients ◽  
Hand Symptoms

A retrospective study of 15 diabetic patients (20 hands), who underwent carpal tunnel release, was performed to determine the outcome. All patients had a minimum of 18 months of follow-up. Outcome was considered excellent if there was complete resolution of symptoms and this occurred in 35% of the treated hands. Eight hands (40%) had a good outcome with significant improvement of pre-operative symptoms. Outcome was considered poor when symptoms were minimally improved, unchanged, or worse after surgery and this occurred in 25% of treated hands. All hands with a poor final result had either no electrodiagnostic evidence of localized compression or only mild compression in pre-operative nerve conduction studies. It was postulated that the contribution of localized compression to pre-operative hand symptoms was less than the contribution of peripheral neuropathy in these hands.

Low doses of ketoconazole and prednisone in patients with castration resistant prostate cancer (CRPC): A retrospective study on 73 patients.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e16099-e16099
Author(s):  
Gloria Amaniera ◽  
Valentina Ballatore ◽  
Fiorella Ruatta ◽  
Veronica Prati ◽  
Leonardo D'Urso ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Median Duration ◽  
Progression Free Survival ◽  
Biochemical Response ◽  
Low Doses ◽  
Castration Resistant Prostate Cancer ◽  
Adrenal Androgen ◽  
Androgen Synthesis ◽  
Maximal Androgen Blockade ◽  
Androgen Blockade

e16099 Background: The management of rising PSA in metastatic CRPC remains controversial. In Italy, abiraterone and enzalutamide are not at all approved in this setting of patients (pts). Ketoconazole is an inhibitor of adrenal androgen synthesis that has shown anti-tumor activity by interfering with C-17,20-lyase and could be used as secondary hormonal manipulation. In this retrospective study we report our experience with low doses of ketoconazole and prednisone in the treatment for CRPC. Methods: From March 2007 to March 2012, 73 pts with progressive CRPC who were previously treated with maximal androgen blockade received 200 mg ketoconazole orally 2 times daily, orally replacement prednisone (5 mg bid) and maintained LHRH-agonists. Overall, 40/73 (55%) pts had only bone metastases, 13/73 (18%) had nodal metastases, 20/73 (27%) both. Pts were monitored clinically and with serial PSA measurements every month. Partial biochemical response (PR) was defined as a >50% fall in PSA from baseline. Progressive disease (PD) was defined by objective disease progression or PSA increase of >50% above nadir or >25% above baseline. The endpoints of the study were biochemical response (BR), progression free survival (PFS), overall survival (OS) and adverse events assessment. Results: Median age was 74 (70-78) years; median baseline PSA was 33.09 (1.18-1348.8) ng/ml; median duration of the treatment was 5.05 (0-56.8) months. Twenty out 73 pts (27%) showed a decrease in PSA >50%, with a median duration of PSA response of 3.56 (1.17-33.58) months and 3 pts (4%) a PD. Fifty out 73 pts (68%) achieved a SD with an overall disease control (PR+SD) of 85%. PFS was 10 months for pts who achieved PR and 4 months for those with SD. Differences in PFS stratified according to site of metastases showed better prognosis in patients with only lymph nodes disease (p<0.05). Treatment with Ketoconazole was well tolerated and grades 3-4 toxicities occurred in only 3% of patients. Conclusions: Low-dose ketoconazole is an effective and well-tolerated treatment in pts with CRPC and should be considered in the subset of pts with low tumor burden and a rising PSA level despite maximal androgen blockade.

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