scholarly journals AB0908 ARE CHRONIC PAIN SYNDROMES BEHIND STATIN-ASSOCIATED MUSCLE PAIN?

2019 ◽  
Author(s):  
Yarden Yavne ◽  
Rivka Sheinin ◽  
Rita Nogueira ◽  
Nicola Luigi Bragazzi ◽  
Shmuel Tiosano ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Muscle Pain ◽  
Pain Syndromes ◽  
Chronic Pain Syndromes

Clinical Profiles of Patients with Chronic Pain Syndromes of Lumbosacral Localization

TRAUMA ◽  
2016 ◽  
Vol 17 (2) ◽  
pp. 78
Author(s):  
V.I. Romanenko ◽  
I.V. Romanenko ◽  
Yu.I. Romanenko
Keyword(s):  
Chronic Pain ◽  
Pain Syndromes ◽  
Clinical Profiles ◽  
Chronic Pain Syndromes

Radiotherapy-Specific Chronic Pain Syndromes in the Cancer Population: An Evidence-Based Narrative Review

2021 ◽  
Author(s):  
Jay Karri ◽  
Laura Lachman ◽  
Alex Hanania ◽  
Anuj Marathe ◽  
Mani Singh ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Narrative Review ◽  
Evidence Based ◽  
Pain Syndromes ◽  
Chronic Pain Syndromes

scholarly journals P124 Are chronic pain syndromes associated with a unique cytokine profile? A systematic review and meta-analysis

Rheumatology ◽  
2021 ◽  
Vol 60 (Supplement_1) ◽  
Author(s):  
Luke Furtado O'Mahony ◽  
Arnav Srivastava ◽  
Puja Mehta ◽  
Coziana Ciurtin
Keyword(s):  
Systematic Review ◽  
Chronic Pain ◽  
Meta Analysis ◽  
Pooled Analysis ◽  
Cross Sectional ◽  
Pain Syndromes ◽  
Newcastle Ottawa Scale ◽  
Cytokine Milieu ◽  
Analysis Models ◽  
Chronic Pain Syndromes

Abstract Background/Aims  The aetiology of primary chronic pain syndromes (CPS) is highly disputed. One theory suggests that pain is due to a pro-inflammatory cytokine milieu leading to nociceptive activation. We performed a systematic review and meta-analysis aiming to assess differences in cytokines levels in CPS patients versus healthy controls (HC). Methods  Human studies published in English from PubMed, MEDLINE/Scopus and Cochrane databases were searched from inception up to January 2020. We included full text cross-sectional or longitudinal studies with cytokine measurements in CPS patients and HC. We excluded studies with underlying organic pathology. Quality assessment was completed using a modified version of the Newcastle-Ottawa Scale. Random-effects meta-analysis models were used to report pooled effects and 95% CIs. Study registered with PROSPERO (CRD42020193774). Results  Initial search yielded 324 papers, 36 studies (3229 participants) eligible for systematic review and 26 studies (2048 participants) suitable for metaanalysis. There were reproducible findings supporting trends of cytokine levels comparing CPS patients with HC. Eotaxin (chemokine) however was consistently raised in CPS. Meta-analysis showed significantly increased tumour necrosis factor (TNF) (SMD=0.39, p = 0.0009, %95I=0.16-0.63, p < 0.001; I2=70%, Q2 p < 0.001), interleukin (IL)-6 (SMD=0.15, 8 (SMD=0.26, p = 0.01, 95%CI =0.05-0.47; I2=61%, Q2 p = 0.005) and IL-10 (SMD=0.61; %95 = 0.34-0.89, p < 0.001; I2 = 10%, Q2 p = 0.34) in CPS compared to HC. Conclusion  We found significant differences in peripheral blood cytokine profiles of CPS patients compared to HC. However, the distinctive profile associated with CPS includes both pro-inflammatory (TNF-α, IL-6, IL-8), and anti-inflammatory cytokines (IL-10) in pooled analysis, as well as chemokine (eotaxin) signatures. Disclosure  L. Furtado O'Mahony: None. A. Srivastava: None. P. Mehta: None. C. Ciurtin: None.

scholarly journals Sickle cell pain: a critical reappraisal

Blood ◽  
2012 ◽  
Vol 120 (18) ◽  
pp. 3647-3656 ◽  
Author(s):  
Samir K. Ballas ◽  
Kalpna Gupta ◽  
Patricia Adams-Graves
Keyword(s):  
Chronic Pain ◽  
Neuropathic Pain ◽  
Sickle Cell ◽  
Multiorgan Failure ◽  
Organ Damage ◽  
Acute Chest Syndrome ◽  
Prodromal Phase ◽  
Pain Syndromes ◽  
Painful Episode ◽  
Chronic Pain Syndromes

AbstractSickle cell pain includes 3 types: acute recurrent painful crises, chronic pain syndromes, and neuropathic pain. The acute painful crisis is the hallmark of the disease and the most common cause of hospitalization and treatment in the emergency department. It evolves through 4 phases: prodromal, initial, established, and resolving. Each acute painful episode is associated with inflammation that worsens with recurrent episodes, often culminating in serious complications and organ damage, such as acute chest syndrome, multiorgan failure, and sudden death. Three pathophysiologic events operate in unison during the prodromal phase of the crisis: vaso-occlusion, inflammation, and nociception. Aborting the acute painful episode at the prodromal phase could potentially prevent or minimize tissue damage. Our hypothesis is that managing these events with hydration, anti-inflammatory drugs, aggressive analgesia, and possibly vasodilators could abort the crisis and prevent or minimize further damage. Chronic pain syndromes are associated with or accompany avascular necrosis and leg ulcers. Neuropathic pain is not well studied in patients with sickle cell disease but has been modeled in the transgenic sickle mouse. Management of sickle cell pain should be based on its own pathophysiologic mechanisms rather than borrowing guidelines from other nonsickle pain syndromes.

LOWER URINARY TRACT SYNDROME IN ELDERLY AND SENILE PEOPLE WITH COMBINED PATHOLOGY OF THE PROSTATE AND LUMBAR SPINE

2021 ◽  
pp. 921-926
Author(s):  
В. В. Третьяков ◽  
В. С. Мякотных
Keyword(s):  
Chronic Pain ◽  
Urinary Tract ◽  
Lumbar Spine ◽  
Clinical Picture ◽  
Lower Urinary Tract ◽  
Lumbar Region ◽  
Urination Disorders ◽  
Pain Syndromes ◽  
Chronic Pain Syndromes ◽  
Lower Urinary

Для определения места и роли дегенеративных изменений поясничного отдела позвоночника в патогенезе синдрома нижних мочевых путей и успешности проведения лечебных мер наблюдали 106 мужчин пожилого и старческого возраста, страдающих доброкачественной гиперплазией предстательной железы и патологией позвоночника. Длительные хронические боли в пояснице испытывали 48 (45,3 %) пациентов, у 93,8 % из них отмечали никтурию, у 75 % - затруднения при мочеиспускании, у 60,4 % - ложные позывы на мочеиспускание, что мотивировало обращение к урологу. Выявленные с помощью опросника IPSS различия, соответственно 21,78±4,33 и 16,33±4,61 балла, указывали на негативное значение хронического болевого синдрома в формировании общей клинической картины урологической патологии. У лиц старческого возраста болевой синдром и симптомы раздражения мочевых путей были менее выраженными, чем у лиц пожилого возраста, а обструктивные симптомы, наоборот, более отчетливыми. Хронические болевые синдромы в поясничной области значительно чаще ( р <0,001)регистрировали у 67 пациентов с удовлетворительными и неудовлетворительными результатами лечения по поводу расстройств мочеиспускания, чем у 39 с наилучшей эффективностью. Таким образом, патология поясничного отдела позвоночника и связанные с ней хронические болевые синдромы вносят существенный вклад в патогенез и клиническую картину синдрома нижних мочевых путей и в результативность лечения расстройств мочеиспускания. Выявленные особенности следует учитывать в процессе диагностики и лечения комбинированной патологии. In order to determine the place and role of degenerative changes in the lumbar spine in the pathogenesis of lower urinary tract syndrome and the success of treatment measures, 106 elderly and senile male patients suffering from benign prostatic hyperplasia and spinal pathology were observed. Long-term chronic lower back pain was experienced by 48 (45,3 %) patients, 93,8 % of them had night urination, 75 % had difficulty urinating, and 60,4 % had false urge to urinate, which motivated them to contact a urologist.The differences identified using the IPSS questionnaire, respectively 21,78±4,33 and 16,33±4,61 points, indicated a negative value of chronic pain syndrome in the formation of the overall clinical picture of urological pathology. Among the senile patients, pain and urinary tract irritation symptoms were less pronounced than among the elderly patients, and obstructive symptoms, on the contrary, were more pronounced. Chronic pain syndromes in the lumbar region were significantly more frequent ( p <0,001) among 67 patients with satisfactory and unsatisfactory results of treatment for urination disorders than among 39 with the best efficiency. Thus, the pathology of the lumbar spine and associated chronic pain syndromes make a significant contribution to the pathogenesis and clinical picture of the lower urinary tract syndrome and to the effectiveness of treatment of urination disorders. The identified features should be taken into account in the process of diagnosis and treatment of combined pathology.

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