scholarly journals AB1111 RELATIONSHIP BETWEEN SERUM ADENOSINE DEAMINASE LEVELS AND DISEASE ACTIVITY IN AUTOIMMUNE HEPATITIS

2019 ◽  
Author(s):  
Jing Xie ◽  
Hua Wei ◽  
Xiaoxing Xiang
Keyword(s):  
Disease Activity ◽  
Autoimmune Hepatitis ◽  
Adenosine Deaminase

scholarly journals Relationship between serum adenosine deaminase levels and liver histology in autoimmune hepatitis

2017 ◽  
Vol 23 (21) ◽  
pp. 3876 ◽  
Author(s):  
Murat Torgutalp ◽  
Cumali Efe ◽  
Hakan Babaoglu ◽  
Taylan Kav
Keyword(s):  
Autoimmune Hepatitis ◽  
Adenosine Deaminase ◽  
Liver Histology

Autoantibodies to asialoglycoprotein receptor (ASGPR) measured by a novel ELISA—Revival of a disease-activity marker in autoimmune hepatitis

2009 ◽  
Vol 408 (1-2) ◽  
pp. 19-24 ◽  
Author(s):  
Gert Hausdorf ◽  
Dirk Roggenbuck ◽  
Eugen Feist ◽  
Thomas Büttner ◽  
Peter R. Jungblut ◽  
...  
Keyword(s):  
Disease Activity ◽  
Autoimmune Hepatitis ◽  
Asialoglycoprotein Receptor ◽  
Activity Marker

scholarly journals Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis

2020 ◽  
Author(s):  
Amédée Renand ◽  
Iñaki Cervera-Marzal ◽  
Laurine Gil ◽  
Chuang Dong ◽  
Erwan Kervagoret ◽  
...  
Keyword(s):  
T Cells ◽  
Disease Activity ◽  
Autoimmune Hepatitis ◽  
Peripheral Blood ◽  
Cd4 T Cells ◽  
Ex Vivo ◽  
B Cell Differentiation ◽  
Tcr Repertoire ◽  
First Time

AbstractBackground & AimsIn most autoimmune disorders, crosstalk of B cells and CD4 T cells results in the accumulation of autoantibodies. In autoimmune hepatitis (AIH), the presence of anti-Soluble Liver Antigen (SLA or SepSecs) autoantibodies is associated with significantly reduced overall survival, but the associated autoreactive CD4 T cells have not been characterized yet. Here we isolated and deeply characterized SLA-specific CD4 T cells in AIH patients.MethodsWe used brief ex vivo restimulation with overlapping SLA-derived peptides to isolate and phenotype circulating SLA-specific CD4 T cells, and integrative single-cell RNA-seq (scRNA-seq) to characterize their transcriptome and TCR repertoire in n=5 AIH patients. SLA-specific CD4 T cells were tracked in peripheral blood through TCR sequencing, to identify their phenotypic niche. We further characterized disease-associated peripheral blood T cells by high content flow cytometry in an additional cohort of n=46 AIH patients and n=18 non-alcoholic steatohepatitis (NASH) controls.ResultsAutoreactive SLA-specific CD4 T cells were only detected in patients with anti-SLA autoantibodies and had a memory PD-1+CXCR5−CCR6−CD27+ phenotype. ScRNA-seq revealed their pro-inflammatory/B-Helper profile (IL21, IFNG, TIGIT, CTLA4, NR3C1, CD109, KLRB1 and CLEC2D). Autoreactive TCR clonotypes were restricted to the memory PD-1+CXCR5− CD4 T cells. This subset was significantly increased in the blood of AIH patients and supported B cell differentiation through IL-21. Finally, we identified a specific phenotype (PD-1+CD38+CD27+CD127−CXCR5−) of CD4 T cells linked to disease activity and IgG response during AIH.ConclusionsThis work provides for the first time a deep characterization of rare circulating autoreactive CD4 T cells and the identification of their peripheral reservoir in AIH. We also propose a generic phenotype of pathogenic CD4 T cells related to AIH disease activity.

Patients with autoimmune hepatitis and liver cirrhosis have disease activity despite normal transaminases

2020 ◽  
Vol 73 ◽  
pp. S87-S88
Author(s):  
Alena Laschtowitz ◽  
Kalliopi Zachou ◽  
Vasiliki Lygoura ◽  
Simon Pape ◽  
Finn Derben ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Disease Activity ◽  
Autoimmune Hepatitis

Soluble programmed death-1 levels are associated with disease activity and treatment response in patients with autoimmune hepatitis

2016 ◽  
Vol 52 (1) ◽  
pp. 93-99 ◽  
Author(s):  
Kristian Aarslev ◽  
Anders Dige ◽  
Stinne R. Greisen ◽  
Martin Kreutzfeldt ◽  
Niels Jessen ◽  
...  
Keyword(s):  
Disease Activity ◽  
Autoimmune Hepatitis ◽  
Treatment Response ◽  
Programmed Death ◽  
Programmed Death 1

Serum adenosine deaminase may predict disease activity in rheumatoid arthritis

2011 ◽  
Vol 32 (7) ◽  
pp. 1967-1975 ◽  
Author(s):  
Batool Zamani ◽  
Raika Jamali ◽  
Arsia Jamali
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Adenosine Deaminase

Transforming growth factor-β1 in autoimmune hepatitis: correlation of liver tissue expression and serum levels with disease activity

1998 ◽  
Vol 28 (5) ◽  
pp. 803-811 ◽  
Author(s):  
Elke M. Bayer ◽  
Wolfgang Herr ◽  
Stephan Kanzler ◽  
Christine Waldmann ◽  
Karl-Hermann Meyer Zum Büschenfelde ◽  
...  
Keyword(s):  
Growth Factor ◽  
Disease Activity ◽  
Autoimmune Hepatitis ◽  
Liver Tissue ◽  
Transforming Growth Factor ◽  
Serum Levels ◽  
Tissue Expression ◽  
Transforming Growth Factor Β1

Polyclonal T-Cell Responses to Cytochrome P450IID6 Are Associated With Disease Activity in Autoimmune Hepatitis Type 2

2006 ◽  
Vol 130 (3) ◽  
pp. 868-882 ◽  
Author(s):  
Yun Ma ◽  
Dimitrios P. Bogdanos ◽  
Munther J. Hussain ◽  
James Underhill ◽  
Sanjay Bansal ◽  
...  
Keyword(s):  
T Cell ◽  
Disease Activity ◽  
Autoimmune Hepatitis ◽  
T Cell Responses ◽  
Cell Responses
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