scholarly journals AB0650 SCREENING TESTS FOR LATENT TUBERCULOSIS OF CANDIDATES TO BIOLOGIC THERAPY: DATA FROM THE TUNISIAN BINAR REGISTRY

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1358.1-1358
Author(s):  
R. Ben Aissa ◽  
S. Boussaid ◽  
S. Kochbati ◽  
M. El Euch ◽  
A. Laatar ◽  
...  
Keyword(s):  
Biologic Therapy ◽  
Latent Tuberculosis ◽  
Diagnostic Value ◽  
Interferon Γ ◽  
National Registry ◽  
Screening Tests ◽  
Inflammatory Rheumatic Diseases ◽  
Igra Test ◽  
Significant Difference ◽  
Release Assay

Background:The screening and treatment of latent tuberculosis infection (LTBI) is required before starting biologic therapy. Tuberculin skin test (TST) and interferon γ gamma release assay (IGRA) are the two commonly used tests.Objectives:The aim of our study was to analyze data from the Biological National Registry BINAR between 2016 and 2020 in order to compare the diagnostic value of TST and IGRA tests.Methods:We collected data of patients diagnosed with LTBI (having had a TST and/or IGRA before receiving any biotherapy) from the BINAR registry (a National Tunisian registry of patients with inflammatory rheumatic diseases under biologic therapy since less than two years from the inclusion date).Results:From a total of 298 patients included in our study, 199 patients (66.8%) were screened by TST and 159 patients were screened (53.4%) by IGRA.Thirty-four patients (11.4%) had a positive TST and 27 patients (9.1%) had a positive IGRA test.Three patients having negative TST and two having negative IGRA developed tuberculosis.There was no significant difference in our study between these two tests for LTBI diagnosis. The reactivation of tuberculosis can occur even when LTBI screening is negative using TST and IGRA tests.Conclusion:Our results show that the predictive diagnostic value for these two tests is the same. It would be more interesting to practice one of those tests prior to biotherapy.Disclosure of Interests:None declared.

Use of a T Cell Interferon-γ Release Assay to Evaluate Tuberculosis Risk in Newly Qualified Physicians in Singapore Healthcare Institutions

2009 ◽  
Vol 30 (9) ◽  
pp. 870-875 ◽  
Author(s):  
C. B. E. Chee ◽  
L. K. Y. Lim ◽  
T. M. Barkham ◽  
D. R. Koh ◽  
S. O. Lam ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Latent Tuberculosis ◽  
Risk Groups ◽  
Interferon Γ ◽  
Public Hospitals ◽  
High Rate ◽  
Assay Result ◽  
Release Assay ◽  
Baseline Test ◽  
Tuberculosis Risk

Background.Surveillance for latent tuberculosis in high-risk groups such as healthcare workers is limited by the nonspecificity of the tuberculin skin test (TST) in BCG-vaccinated individuals. The Mycobacterium tuberculosis antigen-specific interferon-γ release assays (IGRAs) show promise for more accurate latent tuberculosis detection in such groups.Objective.To compare the utility of an IGRA, the T-SPOT.TB assay, with that of the TST in healthcare workers with a high rate of BCG vaccination.Methods.Two hundred seven medical students from 2 consecutive cohorts underwent the T-SPOT.TB test and the TST in their final year of study. Subjects with negative baseline test results underwent repeat testing after working for 1 year as junior physicians in Singapore's public hospitals.Results.The baseline TST result was an induration 10 mm or greater in diameter in 177 of the 205 students who returned to have their TST results evaluated (86.3%), while the baseline T-SPOT.TB assay result was positive in 9 (4.3%) of the students. Repeat T-SPOT.TB testing in 182 baseline-negative subjects showed conversion in 9 (4.9%). A repeat TST in 18 subjects with baseline-negative TST results did not reveal any TST result conversion.Conclusions.The high rate of positive baseline TST results in our BCG-vaccinated healthcare workers renders the TST unsuitable as a surveillance tool in this tuberculosis risk group. Use of an IGRA has enabled the detection and treatment of latent tuberculosis in this group. Our T-SPOT.TB conversion rate highlights the need for greater tuberculosis awareness and improved infection control practices in our healthcare institutions.

Utility of an Interferon-γ Release Assay for Latent Tuberculosis Diagnosis in a Case of Bullous Pemphigoid

2009 ◽  
Vol 13 (5) ◽  
pp. 280-282 ◽  
Author(s):  
Alfred Goodfellow ◽  
Douglas N. Keeling ◽  
Robert C. Hayes ◽  
Duncan Webster
Keyword(s):  
Tuberculin Skin Test ◽  
Bullous Pemphigoid ◽  
Skin Test ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Interferon Γ ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Cutaneous Disease ◽  
Release Assay

Background: With increasing use of immunosuppressive therapy, including tumor necrosis factor a inhibitors, there is concern about infectious complications, including reactivation of latent Mycobacterium tuberculosis infection. Routine testing prior to administration of systemic immunosuppression includes the tuberculin skin test, which lacks sensitivity and specificity and may be difficult to interpret in the presence of extensive cutaneous disease. Treatment of individuals with latent tuberculosis infection is recommended when immunosuppressive medications are to be employed. Observations: We report a case in which a diagnosis of latent tuberculosis infection in a patient with extensive bullous pemphigoid was clarified by the use of an interferon-γ release assay after equivocal tuberculin skin test results. Conclusion: Interferon-γ release assays are useful adjuncts to the tuberculin skin test in the diagnosis of latent tuberculosis infection in the setting of extensive cutaneous disease.

scholarly journals Impact of interferon-γ release assay on the latent tuberculosis cascade of care: a population-based study

2017 ◽  
Vol 49 (3) ◽  
pp. 1601546 ◽  
Author(s):  
David Z. Roth ◽  
Lisa A. Ronald ◽  
Daphne Ling ◽  
Leslie Y. Chiang ◽  
Victoria J. Cook ◽  
...  
Keyword(s):  
Latent Tuberculosis ◽  
Interferon Γ ◽  
Population Based ◽  
Population Based Study ◽  
Cascade Of Care ◽  
Release Assay

Serial interferon-γ release assay in children with latent tuberculosis infection and children with tuberculosis

2011 ◽  
Vol 47 (4) ◽  
pp. 401-408 ◽  
Author(s):  
Nataųa Nenadić ◽  
Branka Kristić Kirin ◽  
Ivka Zoričić Letoja ◽  
Davor Plavec ◽  
Renata Zrinski Topić ◽  
...  
Keyword(s):  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Interferon Γ ◽  
Tuberculosis Infection ◽  
Release Assay

Rate of Latent Tuberculosis Infection Detected by Occupational Health Screening of Nurses New to a London Teaching Hospital

2009 ◽  
Vol 30 (6) ◽  
pp. 581-584 ◽  
Author(s):  
Priya Khanna ◽  
Vladyslav Nikolayevskyy ◽  
Fiona Warburton ◽  
Elek Dobson ◽  
Francis Drobniewski
Keyword(s):  
Tuberculin Skin Test ◽  
Skin Test ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Interferon Γ ◽  
Tuberculosis Infection ◽  
Release Assay ◽  
Ifn Γ ◽  
Positive Results ◽  
Tuberculosis Prevalence

The prevalence of latent tuberculosis infection in a cohort of nurses new to a London hospital was 7.6% (13 of 171), using an interferon-γ(IFN-γ) release assay, and 16.2% (24 of 148), using the tuberculin skin test. On multivariate analysis, birth in a country with tuberculosis prevalence of more than 40 cases per 100,000 population was associated with positive results of both the IFN-γ release assay and the tuberculin skin test.

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